Neuroprotectin (original) (raw)
Neuroprotectin D1 (NPD1) (10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid) also known as Protectin D1 (PD1) is a docosanoid derived from the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), which is a component of fish oil and the most important omega-3 PUFA. Like other members of the specialized proresolving mediators class of PUFA metabolites, NPD1 exerts potent anti-inflammatory and anti-apoptotic/neuroprotective bioactivity. Other neuroprotectins with similar activity include: PDX (10R,17S-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid); 20-hydroxy-PD1 (10R,17S,20-trihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid); and 10-epi-PD1 (10R,17S-Dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid). The activity of neuroprotectin-like metabolite, 17-epi-PD1
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| dbo:abstract | Neuroprotectin D1 (NPD1) (10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid) also known as Protectin D1 (PD1) is a docosanoid derived from the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), which is a component of fish oil and the most important omega-3 PUFA. Like other members of the specialized proresolving mediators class of PUFA metabolites, NPD1 exerts potent anti-inflammatory and anti-apoptotic/neuroprotective bioactivity. Other neuroprotectins with similar activity include: PDX (10R,17S-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid); 20-hydroxy-PD1 (10R,17S,20-trihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid); and 10-epi-PD1 (10R,17S-Dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid). The activity of neuroprotectin-like metabolite, 17-epi-PD1 (10R,17R-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid), has not yet been reported. Neuroprotectins A and B, which are bicyclohexapeptides, are to be distinguished structurally and mechanistically from the neuroprotectin D's. (en) |
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| dbo:wikiPageRevisionID | 1120102353 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Protectin_D1 dbr:Anti-inflammatory dbc:Cell_biology dbc:Fatty_acids dbc:Immunology dbr:Docosanoid dbc:Metabolic_pathways dbr:Docosahexaenoic_acid dbr:Apoptotic dbr:Specialized_proresolving_mediators dbr:Neuroprotection dbr:Polyunsaturated_fatty_acid |
| dbp:wikiPageUsesTemplate | dbt:Biochem-stub dbt:Merge_to dbt:Short_description |
| dcterms:subject | dbc:Cell_biology dbc:Fatty_acids dbc:Immunology dbc:Metabolic_pathways |
| gold:hypernym | dbr:Docosanoid |
| rdfs:comment | Neuroprotectin D1 (NPD1) (10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid) also known as Protectin D1 (PD1) is a docosanoid derived from the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), which is a component of fish oil and the most important omega-3 PUFA. Like other members of the specialized proresolving mediators class of PUFA metabolites, NPD1 exerts potent anti-inflammatory and anti-apoptotic/neuroprotective bioactivity. Other neuroprotectins with similar activity include: PDX (10R,17S-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid); 20-hydroxy-PD1 (10R,17S,20-trihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid); and 10-epi-PD1 (10R,17S-Dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid). The activity of neuroprotectin-like metabolite, 17-epi-PD1 (en) |
| rdfs:label | Neuroprotectin (en) |
| owl:sameAs | freebase:Neuroprotectin yago-res:Neuroprotectin wikidata:Neuroprotectin https://global.dbpedia.org/id/4sGJR |
| prov:wasDerivedFrom | wikipedia-en:Neuroprotectin?oldid=1120102353&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Neuroprotectin |
| is dbo:wikiPageWikiLink of | dbr:Protectin_D1 dbr:Inflammation dbr:Essential_fatty_acid dbr:Essential_fatty_acid_interactions dbr:Lipoxin dbr:Docosanoid dbr:Docosapentaenoic_acid dbr:Nicolas_Bazan dbr:Efferocytosis |
| is foaf:primaryTopic of | wikipedia-en:Neuroprotectin |