| dbo:abstract |
لمفوما هودجكين السائدة الخلايا الليمفية العقيدية هي شكل من أشكال اللمفوما. (ar) Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a slow-growing CD20 positive form of Hodgkin lymphoma, a cancer of the immune system's B cells. NLPHL is an uncommon sub-type of Hodgkin lymphoma, making up 5-10% of Hodgkin lymphomas. It is distinguished from classic Hodgkin lymphoma by the presence of CD20 positive lymphocyte predominant cells, also known as popcorn cells due to their polylobated nuclei, which look like popcorn. There are small but clear differences in prognosis between the various forms. Lymphocyte predominant HL is an uncommon subtype composed of vague nodules of numerous reactive lymphocytes admixed with large popcorn-shaped RSC. Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20. The anti-CD20 monoclonal antibody Rituximab has been used in lymphocyte predominant Hodgkin lymphoma with encouraging results. BCL6 gene rearrangements have been frequently observed. (en) |
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C81.0 |
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201.9 |
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| dbp:caption |
Micrograph of a lymph node biopsy showing nodular lymphocyte predominant Hodgkin lymphoma, with the Reed–Sternberg cell variant that has a popcorn-shaped nucleus . H&E stain. (en) |
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Hematology and oncology (en) |
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| rdfs:comment |
لمفوما هودجكين السائدة الخلايا الليمفية العقيدية هي شكل من أشكال اللمفوما. (ar) Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a slow-growing CD20 positive form of Hodgkin lymphoma, a cancer of the immune system's B cells. NLPHL is an uncommon sub-type of Hodgkin lymphoma, making up 5-10% of Hodgkin lymphomas. It is distinguished from classic Hodgkin lymphoma by the presence of CD20 positive lymphocyte predominant cells, also known as popcorn cells due to their polylobated nuclei, which look like popcorn. BCL6 gene rearrangements have been frequently observed. (en) |
| rdfs:label |
لمفوما هودجكين السائدة الخلايا الليمفية العقيدية (ar) Nodular lymphocyte predominant Hodgkin lymphoma (en) |
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