| dbo:abstract |
Nortilidin ist ein pharmakologisch aktives Stoffwechselprodukt (Metabolit) des Arzneistoffs Tilidin. Die Substanz aus der Gruppe der Opioide entsteht in der Leber durch Demethylierung aus Tilidin. Nortilidin übt die hauptsächliche Wirkung des verabreichten Tilidins aus, da dieses als Prodrug kaum Wirkung zeigt. Nortilidin wird weiterhin in der Leber nach und nach zum analgetisch inaktiven Bisnortilidin metabolisiert. (de) Nortilidine is the major active metabolite of tilidine. It is formed from tilidine by demethylation in the liver. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine. The (1R,2S) isomer has NMDA antagonist activity. The drug also acts as a dopamine reuptake inhibitor. The reversed-ester of nortilidine is also known, as is the corresponding analogue with the cyclohexene ring replaced by cyclopentane, which have almost identical properties to nortilidine. (en) |
| dbo:casNumber |
38677-94-0 |
| dbo:chEBI |
77839 |
| dbo:chEMBL |
1614654 |
| dbo:fdaUniiCode |
7145G6817J |
| dbo:pubchem |
162321 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Nortilidine.svg?width=300 |
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| dbo:wikiPageWikiLink |
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| dbp:chemspiderid |
142535 (xsd:integer) |
| dbp:h |
21 (xsd:integer) |
| dbp:iupacName |
ethyl -2--1-phenylcyclohex-3-ene-1-carboxylate (en) |
| dbp:n |
1 (xsd:integer) |
| dbp:o |
2 (xsd:integer) |
| dbp:pubchem |
162321 (xsd:integer) |
| dbp:smiles |
CCOC[C@]1C2=CC=CC=C2 (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
PDJZPNKVLDWEKI-GOEBONIOSA-N (en) |
| dbp:unii |
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| dbp:wikiPageUsesTemplate |
dbt:Analgesic-stub dbt:Commons_category-inline dbt:Dopaminergics dbt:Drugbox dbt:Opioidergics dbt:Reflist dbt:Short_description dbt:Ebicite dbt:Glutamatergics |
| dcterms:subject |
dbc:Cyclohexenes dbc:Dopamine_reuptake_inhibitors dbc:NMDA_receptor_antagonists dbc:Opioids |
| gold:hypernym |
dbr:Metabolite |
| rdf:type |
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| rdfs:comment |
Nortilidin ist ein pharmakologisch aktives Stoffwechselprodukt (Metabolit) des Arzneistoffs Tilidin. Die Substanz aus der Gruppe der Opioide entsteht in der Leber durch Demethylierung aus Tilidin. Nortilidin übt die hauptsächliche Wirkung des verabreichten Tilidins aus, da dieses als Prodrug kaum Wirkung zeigt. Nortilidin wird weiterhin in der Leber nach und nach zum analgetisch inaktiven Bisnortilidin metabolisiert. (de) Nortilidine is the major active metabolite of tilidine. It is formed from tilidine by demethylation in the liver. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine. The (1R,2S) isomer has NMDA antagonist activity. The drug also acts as a dopamine reuptake inhibitor. The reversed-ester of nortilidine is also known, as is the corresponding analogue with the cyclohexene ring replaced by cyclopentane, which have almost identical properties to nortilidine. (en) |
| rdfs:label |
Nortilidin (de) Nortilidine (en) |
| owl:sameAs |
freebase:Nortilidine yago-res:Nortilidine wikidata:Nortilidine dbpedia-de:Nortilidine dbpedia-sh:Nortilidine dbpedia-sr:Nortilidine https://global.dbpedia.org/id/JNmB |
| prov:wasDerivedFrom |
wikipedia-en:Nortilidine?oldid=1082987664&ns=0 |
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wiki-commons:Special:FilePath/Nortilidine.svg |
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wikipedia-en:Nortilidine |
| is dbo:wikiPageRedirects of |
dbr:H21NO2 |
| is dbo:wikiPageWikiLink of |
dbr:List_of_designer_drugs dbr:Desmetramadol dbr:List_of_opioids dbr:Tilidine dbr:Analgesic dbr:Norpethidine dbr:H21NO2 dbr:AP-238 dbr:Acetoxymethylketobemidone dbr:C16H21NO2 dbr:Opioid |
| is foaf:primaryTopic of |
wikipedia-en:Nortilidine |
