| dbo:abstract |
ORF3a (المعروف سابقا بـX1 أو U274) هو جين يتواجد لدى فيروسات كورونا التي تنتمي إلى الجنيس المسبب للسارس الذي يشمل سارس-كوف وسارس-كوف-2. ويشفر بروتينا ملحقا طوله حوالي 275 حمض أميني يُعتقد أن له وظيفة فيروبورين. وهو أطول بروتين فيروسي ملحق وكان أول البروتينات الملحقة التي تم تحديدها في فيروس سارس-كوف. (ar) ORF3a (previously known as X1 or U274) is a gene found in coronaviruses of the subgenus Sarbecovirus, including SARS-CoV and SARS-CoV-2. It encodes an accessory protein about 275 amino acid residues long, which is thought to function as a viroporin. It is the largest accessory protein and was the first of the SARS-CoV accessory proteins to be described. (en) |
| dbo:symbol |
bCoV_viroporin |
| dbo:thumbnail |
wiki-commons:Special:FilePath/6xdc_SARS-CoV-2_ORF3a.png?width=300 |
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68681143 (xsd:integer) |
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11268 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1079607640 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Protein-protein_interaction dbr:Sarbecovirus dbr:Plasma_membrane dbr:Merbecovirus dbr:C-terminal dbr:Deltacoronavirus_(genus) dbr:Antigen dbr:Betacoronavirus dbr:Cytoplasm dbr:Virion dbr:ORF3b dbr:ORF3c dbr:ORF7a dbr:Coronavirus dbr:Coronavirus_envelope_protein dbr:Coronavirus_membrane_protein dbr:Coronavirus_nucleocapsid_protein dbr:Coronavirus_spike_protein dbr:SARS dbr:SARS-CoV dbr:SARS-CoV-2 dbr:Essential_gene dbr:Gene_expression dbr:Oligomer dbr:Open_reading_frame dbr:Overlapping_gene dbr:Viral_structural_protein dbr:Gene dbr:Apoptosis dbr:MERS-CoV dbr:Subgenomic_RNA dbr:Embecovirus dbr:Post-translational_modification dbr:COVID-19 dbr:Cation dbr:Gammacoronavirus dbr:Cryo-electron_microscopy dbr:Ion_channel dbc:Coronavirus_proteins dbr:Cysteine dbr:Alphacoronavirus dbr:Cell_culture dbr:Golgi_apparatus dbr:Protein_dimer dbr:Reading_frame dbr:Viral_replication dbr:Transmembrane_protein dbr:Ectodomain dbr:Homology_(biology) dbr:Disulfide_bond dbr:Human_coronavirus_229E dbr:Human_coronavirus_HKU1 dbr:Human_coronavirus_NL63 dbr:Human_coronavirus_OC43 dbr:Antibodies dbr:Sequence_conservation dbr:Genomic dbr:Subcellular_localization dbr:Transmembrane_domain dbr:Viral_structural_proteins dbr:Subgenus dbr:Viroporin dbr:Tetramer dbr:Protein_trafficking dbr:Viral_accessory_protein dbr:Amino_acid_residue dbr:3' dbr:N-glycosylated dbr:N-terminal dbr:ERGIC dbr:O-glycosylation dbr:ORF8a dbr:Sequence_identity |
| dbp:caption |
Cryo-electron microscopy structure of the SARS-CoV-2 ORF3a protein dimer. From . (en) Genomic organisation of isolate Wuhan-Hu-1, the earliest sequenced sample of SARS-CoV-2, indicating the location of ORF3a (en) |
| dbp:interpro |
IPR024407 (en) |
| dbp:name |
Betacoronavirus viroporin (en) |
| dbp:pfam |
PF11289 (en) |
| dbp:size |
29903 (xsd:integer) |
| dbp:symbol |
bCoV_viroporin (en) |
| dbp:taxid |
86693 (xsd:integer) |
| dbp:ucscAssembly |
wuhCor1 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Infobox_protein_family dbt:Reflist dbt:Short_description dbt:PDB dbt:Coronavirus_genomes dbt:Viral_proteins dbt:Infobox_genome |
| dbp:year |
2020 (xsd:integer) |
| dct:subject |
dbc:Coronavirus_proteins |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 dbo:Protein |
| rdfs:comment |
ORF3a (المعروف سابقا بـX1 أو U274) هو جين يتواجد لدى فيروسات كورونا التي تنتمي إلى الجنيس المسبب للسارس الذي يشمل سارس-كوف وسارس-كوف-2. ويشفر بروتينا ملحقا طوله حوالي 275 حمض أميني يُعتقد أن له وظيفة فيروبورين. وهو أطول بروتين فيروسي ملحق وكان أول البروتينات الملحقة التي تم تحديدها في فيروس سارس-كوف. (ar) ORF3a (previously known as X1 or U274) is a gene found in coronaviruses of the subgenus Sarbecovirus, including SARS-CoV and SARS-CoV-2. It encodes an accessory protein about 275 amino acid residues long, which is thought to function as a viroporin. It is the largest accessory protein and was the first of the SARS-CoV accessory proteins to be described. (en) |
| rdfs:label |
ORF3a (ar) ORF3a (en) |
| owl:sameAs |
wikidata:ORF3a dbpedia-ar:ORF3a https://global.dbpedia.org/id/GBMvH |
| prov:wasDerivedFrom |
wikipedia-en:ORF3a?oldid=1079607640&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/SARS-CoV-2_genome.svg wiki-commons:Special:FilePath/6xdc_SARS-CoV-2_ORF3a.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:ORF3a |
| is dbo:wikiPageWikiLink of |
dbr:ORF3b dbr:ORF3c dbr:ORF3d dbr:ORF7a dbr:SARS-CoV-2_Beta_variant dbr:SARS-CoV-2_Delta_variant dbr:SARS-related_coronavirus dbr:RaTG13 dbr:AlphaFold dbr:SARS-CoV-2_Mu_variant dbr:SARS-CoV-2_Kappa_variant |
| is foaf:primaryTopic of |
wikipedia-en:ORF3a |
