Orexin receptor (original) (raw)

dbo:abstract

Les récepteurs de l'hypocrétine, également appelés récepteurs de l'orexine, sont des récepteurs couplés aux protéines G. Il existe deux variantes, chacune codée par un gène HCRTR1 et HCRTR2. (fr)
The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX1 and OX2, each encoded by a different gene (HCRTR1, HCRTR2). Both orexin receptors exhibit a similar pharmacology – the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and, in each case, agonist binding results in an increase in intracellular calcium levels. However, orexin-B shows a 5- to 10-fold selectivity for orexin receptor type 2, whilst orexin-A is equipotent at both receptors. Several orexin receptor antagonists are in development for potential use in sleep disorders. The first of these, suvorexant, has been on the market in the United States since 2015. There were two orexin agonists under development as of 2019. (en)

dbo:arm

dbo:band

dbo:chromosome

dbo:entrezgene

3061
3062

dbo:hgncid

4848
4849

dbo:locusSupplementaryData

-q11

dbo:omim

602392 (xsd:integer)
602393 (xsd:integer)

dbo:refseq

NM_001525
NM_001526

dbo:symbol

Orexin_rec2
HCRTR1
HCRTR2

dbo:uniprot

O43613
O43614

dbo:wikiPageExternalLink

https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward%3FfamilyId=51

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13053833 (xsd:integer)

dbo:wikiPageLength

11176 (xsd:nonNegativeInteger)

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1116900244 (xsd:integer)

dbo:wikiPageWikiLink

dbp:arm

p (en)

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11 (xsd:integer)
33 (xsd:integer)

dbp:chromosome

1 (xsd:integer)
6 (xsd:integer)

dbp:entrezgene

3061 (xsd:integer)
3062 (xsd:integer)

dbp:hgncid

4848 (xsd:integer)
4849 (xsd:integer)

dbp:interpro

IPR004060 (en)

dbp:locussupplementarydata

-q11 (en)

dbp:name

dbp:omim

602392 (xsd:integer)
602393 (xsd:integer)

dbp:pfam

PF03827 (en)

dbp:refseq

NM_001525 (en)
NM_001526 (en)

dbp:symbol

Orexin_rec2 (en)
HCRTR1 (en)
HCRTR2 (en)

dbp:uniprot

O43613 (en)
O43614 (en)

dbp:wikiPageUsesTemplate

dct:subject

gold:hypernym

dbr:Receptor

rdf:type

rdfs:comment

Les récepteurs de l'hypocrétine, également appelés récepteurs de l'orexine, sont des récepteurs couplés aux protéines G. Il existe deux variantes, chacune codée par un gène HCRTR1 et HCRTR2. (fr)
The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX1 and OX2, each encoded by a different gene (HCRTR1, HCRTR2). Both orexin receptors exhibit a similar pharmacology – the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and, in each case, agonist binding results in an increase in intracellular calcium levels. However, orexin-B shows a 5- to 10-fold selectivity for orexin receptor type 2, whilst orexin-A is equipotent at both receptors. (en)

rdfs:label

Récepteur de l'hypocrétine (fr)
Orexin receptor (en)

owl:sameAs

prov:wasDerivedFrom

wikipedia-en:Orexin_receptor?oldid=1116900244&ns=0

foaf:isPrimaryTopicOf

wikipedia-en:Orexin_receptor

foaf:name

hypocretin (orexin) receptor 1 (en)
hypocretin (orexin) receptor 2 (en)

is dbo:class of

dbr:ACT-462206

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dbr:Narcolepsy

is foaf:primaryTopic of

wikipedia-en:Orexin_receptor