Oxandrolone (original) (raw)
أوكساندرولون (بالإنجليزية: Oxandrolone) هو دواء يُستعمل في علاج: * فشل النمو
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| dbo:abstract | Oxandrolon (známý také pod obchodní značkou Oxandrin, Anavar, Lonavar), je syntetický perorálně podávaný anabolický androgenní steroid, který byl poprvé dostupný jako lék na předpis ve Spojených státech amerických v roce 1964. Chemicky se jedná o 17α-metylovaný derivát dihydrotestosteronu (DHT), který má místo uhlíku na 2. pozici atom kyslíku. Výzkumní pracovníci a lékaři dříve používali oxandrolon k léčbě široké škály poruch. Patřila k nim idiopatická porucha růstu, Turnerův syndrom, ztráta tělesné hmotnosti z katabolických onemocnění nebo dlouhodobé léčby kortikosteroidy, těžké popáleniny, chirurgická nebo celková trauma, osteoporóza, anémie, dědičný , ztráta vyvolaná HIV/AIDS, a hypogonadismus. Oxandrolon se dnes nejčastěji využívá jako bezpečná léčba pacientů, kteří se zotavují po těžkých popáleninách. Lékařský výzkum rovněž nalezl účinnost oxandrolonu při podpoře vývoje dívky s Turnerovým syndromem. Ačkoli se oxandrolon dlouhodobě používá k urychlení růstu u dětí s idiopatickou nízkou tělesnou hmotností, jako takový nepomáhá ke zvýšení celkové výšky léčeného dospělého. V některých případech došlo k opačnému efektu. Oxandrolon byl proto pro toto použití z velké části nahrazen růstovým hormonem. Někteří kulturisté používají oxandrolon pro zvyšování síly svalů a jejich hustoty. Mimo to má vliv na spalování tuku a téměř žádné vedlejší účinky. Nevýhodou je jeho vysoká cena (cca 200 Kč na den pro 70kg člověka při dovozu z Itálie). Ve většině zemí (například ve Spojených státech, Kanadě či Spojeném království) je takovéto použití látky nezákonné a obvykle se nakupuje od dodavatelů na černém trhu. (cs) أوكساندرولون (بالإنجليزية: Oxandrolone) هو دواء يُستعمل في علاج: * فشل النمو (ar) Η οξανδρολόνη, που πωλείται με τις εμπορικές ονομασίες Oxandrin και Anavar, μεταξύ άλλων, είναι ανδρογόνο και αναβολικό στεροειδές (ΑΑΣ) που χρησιμοποιείται για την αύξηση βάρους σε διάφορες καταστάσεις, για την αντιστάθμιση του πρωτεϊνικού καταβολισμού που προκαλείται από τη μακροχρόνια θεραπεία με κορτικοστεροειδή, για να υποστηρίξει την ανάρρωση από σοβαρά εγκαύματα, για τη θεραπεία του πόνου στα οστά που σχετίζεται με την οστεοπόρωση, για τη βοήθεια στην ανάπτυξη κοριτσιών με σύνδρομο Τέρνερ και για άλλες ενδείξεις. Λαμβάνεται από το στόμα. Οι παρενέργειες της οξανδρολόνης περιλαμβάνουν συμπτώματα αρρενοποίησης όπως ακμή, αυξημένη τριχοφυΐα, αλλαγή φωνής και αυξημένη σεξουαλική επιθυμία. Το φάρμακο είναι συνθετικό ανδρογόνο και αναβολικό στεροειδές, ως εκ τούτου είναι ένας αγωνιστής του υποδοχέα ανδρογόνων, του βιολογικού στόχου των ανδρογόνων όπως η τεστοστερόνη και η . Έχει ισχυρά αναβολικά και αδύναμα ανδρογόνα αποτελέσματα, που του δίνουν ένα ήπιο προφίλ παρενεργειών και το καθιστούν ιδιαίτερα κατάλληλο για χρήση σε γυναίκες. Η οξανδρολόνη περιγράφηκε για πρώτη φορά το 1962 και εισήχθη για ιατρική χρήση το 1964. Χρησιμοποιείται κυρίως στις Ηνωμένες Πολιτείες. Πέρα από τις ιατρικές της χρήσεις, η οξανδρολόνη χρησιμοποιείται για τη βελτίωση της σωματικής διάπλασης και της απόδοσης. Το φάρμακο είναι μια ελεγχόμενη ουσία σε πολλές χώρες, επομένως η μη ιατρική χρήση είναι γενικά παράνομη. (el) Oxandrolon (Handelsnamen Oxandrin und Anavar) ist ein 17-Methylsteroid und ein anaboles Steroid, das erstmals 1962 synthetisiert wurde. Es ist von der Food and Drug Administration (FDA) als orphan drug zugelassen zur Behandlung der alkoholischen Hepatitis, dem Turner-Syndrom und dem Gewichtsverlust durch HIV. Es darf, wie alle verbotenen anabolen Steroide, von Sportlern zu keiner Zeit (auch nicht aus medizinischen Gründen) benutzt werden (→ Dopingliste). (de) L’oxandrolone (Oxandrin) est un dérivé synthétique de la testostérone créé par les Laboratoires Searle, aujourd'hui Pfizer Inc., sous la marque Anavar, et introduit aux États-Unis en 1964. En raison de son potentiel d'abus, il est classé comme une substance réglementée de l'annexe III aux États-Unis. L'oxandrole n’est disponible qu’après autorisation (ATU en France, ASU en Suisse). (fr) Oxandrolone, sold under the brand names Oxandrin and Anavar, among others, is an androgen and anabolic steroid (AAS) medication which is used to help promote weight gain in various situations, to help offset protein catabolism caused by long-term corticosteroid therapy, to support recovery from severe burns, to treat bone pain associated with osteoporosis, to aid in the development of girls with Turner syndrome, and for other indications. It is taken by mouth. Side effects of oxandrolone include symptoms of masculinization such as acne, increased hair growth, voice changes, and increased sexual desire. The drug is a synthetic androgen and anabolic steroid, hence is an agonist of the androgen receptor (AR), the biological target of androgens such as testosterone and dihydrotestosterone. It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women. Oxandrolone was first described in 1962 and was introduced for medical use in 1964. It is used mostly in the United States. In addition to its medical use, oxandrolone is used to improve physique and performance. The drug is a controlled substance in many countries, so nonmedical use is generally illicit. (en) Oxandrolon (Oxandrin) is een anabole steroïde gecreëerd door Searle Laboratories (nu gekend als Pfizer Inc.) onder de merknaam Anavar en in de Verenigde staten geïntroduceerd in 1964. Tegenover de meeste andere anabole steroïden heeft oxandrolon het voordeel dat het niet aromatiseert (omzetting naar oestrogeen, hetgeen gynaecomastie kan veroorzaken). Bij hoge doseringen (dit geldt voor alle androgene anabole steroïden) voelt het lichaam dat het genoeg testosteron heeft en wordt de natuurlijke productie verminderd hetgeen veroorzaakt (krimpen van de testikels). Het zogenoemde nakuren heeft weinig zin. Het medicijn werd voor verschillende aandoeningen, die onvrijwillig gewichtsverlies veroorzaken, voorgeschreven om zo herstelling van de spieren te verkrijgen. Het is ook aangetoond deels succesvol te zijn voor de behandeling van osteoporose. Maar omwille van de slechte publiciteit in verband met het misbruik door bodybuilders werd de productie door Searle Laboratories stopgezet in 1989. Productie werd verdergezet door Bio-Technology General Corporation (nu Savient Pharmaceuticals Inc.) die het uitbrachten onder de merknaam Oxandrin. Dit middel geraakte in 1995 door de klinische tests. (nl) L'oxandrolone è uno steroide di sintesi, derivato del DHT il (diidrotestosterone ), con attività androgena ed anabolizzante. Il farmaco possiede proprietà anabolizzanti più pronunciate di quelle androgene. La presenza nella sua molecola di un gruppo metilico in posizione 17 dell'anello steroideo, lo rende più attivo farmacologicamente, dopo somministrazione orale, e più difficilmente metabolizzabile a livello epatico. Similmente agli altri ormoni anabolizzanti androgeni l'oxandrolone induce ritenzione di azoto, potassio, sodio e fosforo. Il farmaco aumenta l'anabolismo proteico e diminuisce il catabolismo degli aminoacidi e l'eliminazione di calcio. Il bilancio azotato viene migliorato solo se c'è un apporto sufficiente, sia calorico che proteico. (it) Oxandrolona é um fármaco criado por Raphael Pappo enquanto trabalhava para os Laboratórios Searle (hoje Pfizer) sob a marca registrada Anavar. Foi introduzida nos EUA em 1964. É administrado oralmente e seus efeitos são devidos à ligação ao receptor de testosterona. O receptor de testosterona induz ações em nível celular de diversas maneiras, com ações anabolizantes, androgênicas e outras. (pt) 氧雄龙（英語：Oxandrolone）是一种雄激素和同化類固醇（AAS）药物，具有增重效应，能减缓皮質類固醇造成的异化作用，分子式C19H30O3。 (zh) Оксандроло́н — анаболический стероид, впервые синтезированный Raphael Pappo в Searle Laboratories, в настоящее время Pfizer Inc. Выпущен в США под торговой маркой Anavar в 1964 году. Это производное дигидротестостерона, в котором второй атом углерода замещён атомом кислорода, и произведено метилирование в положении 17. (ru) |
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| rdfs:comment | أوكساندرولون (بالإنجليزية: Oxandrolone) هو دواء يُستعمل في علاج: * فشل النمو (ar) Oxandrolon (Handelsnamen Oxandrin und Anavar) ist ein 17-Methylsteroid und ein anaboles Steroid, das erstmals 1962 synthetisiert wurde. Es ist von der Food and Drug Administration (FDA) als orphan drug zugelassen zur Behandlung der alkoholischen Hepatitis, dem Turner-Syndrom und dem Gewichtsverlust durch HIV. Es darf, wie alle verbotenen anabolen Steroide, von Sportlern zu keiner Zeit (auch nicht aus medizinischen Gründen) benutzt werden (→ Dopingliste). (de) L’oxandrolone (Oxandrin) est un dérivé synthétique de la testostérone créé par les Laboratoires Searle, aujourd'hui Pfizer Inc., sous la marque Anavar, et introduit aux États-Unis en 1964. En raison de son potentiel d'abus, il est classé comme une substance réglementée de l'annexe III aux États-Unis. L'oxandrole n’est disponible qu’après autorisation (ATU en France, ASU en Suisse). (fr) Oxandrolona é um fármaco criado por Raphael Pappo enquanto trabalhava para os Laboratórios Searle (hoje Pfizer) sob a marca registrada Anavar. Foi introduzida nos EUA em 1964. É administrado oralmente e seus efeitos são devidos à ligação ao receptor de testosterona. O receptor de testosterona induz ações em nível celular de diversas maneiras, com ações anabolizantes, androgênicas e outras. (pt) 氧雄龙（英語：Oxandrolone）是一种雄激素和同化類固醇（AAS）药物，具有增重效应，能减缓皮質類固醇造成的异化作用，分子式C19H30O3。 (zh) Оксандроло́н — анаболический стероид, впервые синтезированный Raphael Pappo в Searle Laboratories, в настоящее время Pfizer Inc. Выпущен в США под торговой маркой Anavar в 1964 году. Это производное дигидротестостерона, в котором второй атом углерода замещён атомом кислорода, и произведено метилирование в положении 17. (ru) Oxandrolon (známý také pod obchodní značkou Oxandrin, Anavar, Lonavar), je syntetický perorálně podávaný anabolický androgenní steroid, který byl poprvé dostupný jako lék na předpis ve Spojených státech amerických v roce 1964. Chemicky se jedná o 17α-metylovaný derivát dihydrotestosteronu (DHT), který má místo uhlíku na 2. pozici atom kyslíku. (cs) Η οξανδρολόνη, που πωλείται με τις εμπορικές ονομασίες Oxandrin και Anavar, μεταξύ άλλων, είναι ανδρογόνο και αναβολικό στεροειδές (ΑΑΣ) που χρησιμοποιείται για την αύξηση βάρους σε διάφορες καταστάσεις, για την αντιστάθμιση του πρωτεϊνικού καταβολισμού που προκαλείται από τη μακροχρόνια θεραπεία με κορτικοστεροειδή, για να υποστηρίξει την ανάρρωση από σοβαρά εγκαύματα, για τη θεραπεία του πόνου στα οστά που σχετίζεται με την οστεοπόρωση, για τη βοήθεια στην ανάπτυξη κοριτσιών με σύνδρομο Τέρνερ και για άλλες ενδείξεις. Λαμβάνεται από το στόμα. (el) Oxandrolone, sold under the brand names Oxandrin and Anavar, among others, is an androgen and anabolic steroid (AAS) medication which is used to help promote weight gain in various situations, to help offset protein catabolism caused by long-term corticosteroid therapy, to support recovery from severe burns, to treat bone pain associated with osteoporosis, to aid in the development of girls with Turner syndrome, and for other indications. It is taken by mouth. (en) L'oxandrolone è uno steroide di sintesi, derivato del DHT il (diidrotestosterone ), con attività androgena ed anabolizzante. Il farmaco possiede proprietà anabolizzanti più pronunciate di quelle androgene. La presenza nella sua molecola di un gruppo metilico in posizione 17 dell'anello steroideo, lo rende più attivo farmacologicamente, dopo somministrazione orale, e più difficilmente metabolizzabile a livello epatico. (it) Oxandrolon (Oxandrin) is een anabole steroïde gecreëerd door Searle Laboratories (nu gekend als Pfizer Inc.) onder de merknaam Anavar en in de Verenigde staten geïntroduceerd in 1964. Tegenover de meeste andere anabole steroïden heeft oxandrolon het voordeel dat het niet aromatiseert (omzetting naar oestrogeen, hetgeen gynaecomastie kan veroorzaken). Bij hoge doseringen (dit geldt voor alle androgene anabole steroïden) voelt het lichaam dat het genoeg testosteron heeft en wordt de natuurlijke productie verminderd hetgeen veroorzaakt (krimpen van de testikels). Het zogenoemde nakuren heeft weinig zin. (nl) |
| rdfs:label | أوكساندرولون (ar) Oxandrolon (cs) Oxandrolon (de) Οξανδρολόνη (el) Oxandrolone (fr) Oxandrolone (it) Oxandrolon (nl) Oxandrolone (en) Оксандролон (ru) Oxandrolona (pt) 氧雄龙 (zh) |
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