PD-217,014 is a drug developed by Pfizer and related to gabapentin, which similarly binds to the α2δ calcium channels (1 and 2). It was developed as a potentially more potent successor to gabapentin and pregabalin, along with several other analogues such as atagabalin and 4-methylpregabalin, but while PD-217,014 produces visceral analgesic effects in animal studies with higher potency and efficacy than gabapentin, it was not developed further for clinical use because of its comparatively more complex synthesis, compared to other related analogues.
| Property |
Value |
| dbo:abstract |
PD-217,014 is a drug developed by Pfizer and related to gabapentin, which similarly binds to the α2δ calcium channels (1 and 2). It was developed as a potentially more potent successor to gabapentin and pregabalin, along with several other analogues such as atagabalin and 4-methylpregabalin, but while PD-217,014 produces visceral analgesic effects in animal studies with higher potency and efficacy than gabapentin, it was not developed further for clinical use because of its comparatively more complex synthesis, compared to other related analogues. (en) |
| dbo:casNumber |
444088-20-4 |
| dbo:fdaUniiCode |
K2T93E812G |
| dbo:pubchem |
10313401 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/PD-217,014.svg?width=300 |
| dbo:wikiPageID |
34542372 (xsd:integer) |
| dbo:wikiPageLength |
2164 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1082988024 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:4-methylpregabalin dbr:Pregabalin dbr:Pfizer dbc:Abandoned_drugs dbc:Amino_acids dbc:Analgesics dbc:GABA_analogues dbc:Pfizer_brands dbr:Gabapentin dbr:Calcium_channel dbc:Calcium_channel_blockers dbr:Atagabalin dbr:CACNA2D1 dbr:CACNA2D2 |
| dbp:c |
10 (xsd:integer) |
| dbp:casNumber |
444088 (xsd:integer) |
| dbp:chemspiderid |
19264101 (xsd:integer) |
| dbp:h |
17 (xsd:integer) |
| dbp:iupacName |
-3 (xsd:integer) |
| dbp:n |
1 (xsd:integer) |
| dbp:o |
2 (xsd:integer) |
| dbp:pubchem |
10313401 (xsd:integer) |
| dbp:smiles |
C1C[C@@H]2[C@H]1C[C@]CN (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
NDDZVQRQVFTNSN-MBTKJCJQSA-N (en) |
| dbp:unii |
K2T93E812G (en) |
| dbp:width |
175 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Calcium_channel_blockers dbt:Analgesic-stub dbt:Analgesics dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Cascite dbt:Fdacite |
| dcterms:subject |
dbc:Abandoned_drugs dbc:Amino_acids dbc:Analgesics dbc:GABA_analogues dbc:Pfizer_brands dbc:Calcium_channel_blockers |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAminoAcids yago:Abstraction100002137 yago:AminoAcid114601829 yago:Analogue104746430 yago:Attribute100024264 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Quality104723816 yago:Relation100031921 yago:WikicatGABAAnalogues dbo:Drug yago:Sameness104742535 yago:Similarity104743605 yago:Substance100019613 |
| rdfs:comment |
PD-217,014 is a drug developed by Pfizer and related to gabapentin, which similarly binds to the α2δ calcium channels (1 and 2). It was developed as a potentially more potent successor to gabapentin and pregabalin, along with several other analogues such as atagabalin and 4-methylpregabalin, but while PD-217,014 produces visceral analgesic effects in animal studies with higher potency and efficacy than gabapentin, it was not developed further for clinical use because of its comparatively more complex synthesis, compared to other related analogues. (en) |
| rdfs:label |
PD-217,014 (en) |
| owl:sameAs |
freebase:PD-217,014 yago-res:PD-217,014 wikidata:PD-217,014 dbpedia-sh:PD-217,014 dbpedia-sr:PD-217,014 https://global.dbpedia.org/id/4sXK5 |
| prov:wasDerivedFrom |
wikipedia-en:PD-217,014?oldid=1082988024&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/PD-217,014.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:PD-217,014 |
| is dbo:wikiPageWikiLink of |
dbr:C10H17NO2 dbr:Depressant dbr:Gabapentinoid dbr:4-Methylpregabalin dbr:Atagabalin dbr:Imagabalin |
| is foaf:primaryTopic of |
wikipedia-en:PD-217,014 |
