PEST sequence (original) (raw)
PEST-Sequenzen sind Teile von Proteinen, die besonders reich an den Aminosäuren Prolin (P), Glutamat (E), Serin (S) und Threonin (T) sind, welches zu einer geringeren Halbwertszeit t1/2 des gesamten Proteins führt und damit zu einem schnelleren Abbau im Proteasom. Sie sind unter anderem enthalten in Androgen-, Estrogen- und Vitamin-D-Rezeptoren. Die Aktivität von PEST-Sequenzen wird durch Phosphorylierung benachbarter Domänen reguliert.
| Property | Value |
|---|---|
| dbo:abstract | PEST-Sequenzen sind Teile von Proteinen, die besonders reich an den Aminosäuren Prolin (P), Glutamat (E), Serin (S) und Threonin (T) sind, welches zu einer geringeren Halbwertszeit t1/2 des gesamten Proteins führt und damit zu einem schnelleren Abbau im Proteasom. Sie sind unter anderem enthalten in Androgen-, Estrogen- und Vitamin-D-Rezeptoren. Die Aktivität von PEST-Sequenzen wird durch Phosphorylierung benachbarter Domänen reguliert. (de) Una secuencia PEST es una secuencia peptídica rica en residuos de prolina (P), ácido glutámico (E), serina (S), y treonina (T). Dicha secuencia se asocia con proteínas que tienen una vida media celular corta; de ahí que se hipotetice que la secuencia PEST actúa como péptido señal para degradación proteolítica. Dicha degradación puede estar mediada, posiblemente, por el proteasoma o por calpaína. (es) A PEST sequence is a peptide sequence that is rich in proline (P), glutamic acid (E), serine (S), and threonine (T). This sequence is associated with proteins that have a short intracellular half-life; therefore, it is hypothesized that the PEST sequence acts as a signal peptide for protein degradation. This protein degradation may be mediated via the proteasome or calpain. Other signals thought to identify proteins for degradation include cyclin destruction boxes, which are amino acid sequences that mark cell-cycle proteins for destruction. (en) |
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| dbo:wikiPageLength | 2115 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1122556325 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Calpain dbr:Proline dbr:Proteasome dbr:Signal_peptide dbc:Post-translational_modification dbr:Proteolysis dbr:Glutamic_acid dbc:Proteins dbr:Threonine dbr:Protein dbr:Half-life dbc:Peptide_sequences dbr:Serine dbr:Peptide_sequence |
| dbp:wikiPageUsesTemplate | dbt:Reflist dbt:Short_description dbt:Molecular-cell-biology-stub |
| dct:subject | dbc:Post-translational_modification dbc:Proteins dbc:Peptide_sequences |
| gold:hypernym | dbr:Sequence |
| rdf:type | yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins |
| rdfs:comment | PEST-Sequenzen sind Teile von Proteinen, die besonders reich an den Aminosäuren Prolin (P), Glutamat (E), Serin (S) und Threonin (T) sind, welches zu einer geringeren Halbwertszeit t1/2 des gesamten Proteins führt und damit zu einem schnelleren Abbau im Proteasom. Sie sind unter anderem enthalten in Androgen-, Estrogen- und Vitamin-D-Rezeptoren. Die Aktivität von PEST-Sequenzen wird durch Phosphorylierung benachbarter Domänen reguliert. (de) Una secuencia PEST es una secuencia peptídica rica en residuos de prolina (P), ácido glutámico (E), serina (S), y treonina (T). Dicha secuencia se asocia con proteínas que tienen una vida media celular corta; de ahí que se hipotetice que la secuencia PEST actúa como péptido señal para degradación proteolítica. Dicha degradación puede estar mediada, posiblemente, por el proteasoma o por calpaína. (es) A PEST sequence is a peptide sequence that is rich in proline (P), glutamic acid (E), serine (S), and threonine (T). This sequence is associated with proteins that have a short intracellular half-life; therefore, it is hypothesized that the PEST sequence acts as a signal peptide for protein degradation. This protein degradation may be mediated via the proteasome or calpain. Other signals thought to identify proteins for degradation include cyclin destruction boxes, which are amino acid sequences that mark cell-cycle proteins for destruction. (en) |
| rdfs:label | PEST-Sequenz (de) Secuencia PEST (es) PEST sequence (en) |
| owl:sameAs | freebase:PEST sequence yago-res:PEST sequence wikidata:PEST sequence dbpedia-de:PEST sequence dbpedia-es:PEST sequence https://global.dbpedia.org/id/54CLY |
| prov:wasDerivedFrom | wikipedia-en:PEST_sequence?oldid=1122556325&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:PEST_sequence |
| is dbo:wikiPageDisambiguates of | dbr:PEST |
| is dbo:wikiPageRedirects of | dbr:Pest_region dbr:PEST_hypothesis |
| is dbo:wikiPageWikiLink of | dbr:BASP1 dbr:CCNF dbr:Degron dbr:Proteolysis dbr:NF-κB dbr:Cln3 dbr:Hajdu–Cheney_syndrome dbr:PEST dbr:Activity-regulated_cytoskeleton-associated_protein dbr:Lateral_meningocele_syndrome dbr:UHRF2 dbr:Fasciclin_2 dbr:Coiled-coil_domain-containing_37_(FLJ40083) dbr:HIPK2 dbr:Listeriolysin_O dbr:PTRF dbr:MYO10 dbr:Notch_2 dbr:Pest_region dbr:PEST_hypothesis |
| is foaf:primaryTopic of | wikipedia-en:PEST_sequence |