Calpain (original) (raw)
A calpain (/ˈkælpeɪn/; EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin.
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| dbo:abstract | A calpain (/ˈkælpeɪn/; EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin. (en) Las calpaínas (EC 3.4.22.52, EC 3.4.22.53) son , no lisosomales, cuya actividad, de tipo papaína, es dependiente de calcio. Estas enzimas son responsables de la proteólisis neutra calcio-dependiente, en virtud de un dominio de unión a calcio. Este dominio se denomina calmodulin-like por ser altamente homólogo a la calmodulina, presentando las estructuras típicas manos EF de unión a ion calcio. El centro activo de las calpaínas está compuesto de una tríada catalítica formada por cisteína (C), histidina (H) y Asparagina (N). (es) Les calpaïnes (EC 3.4.22.52, EC 3.4.22.53) sont des protéases à cystéine, non-lysosomiales, dont l'activité, de type papaïne, est dépendante du calcium. Ces enzymes sont responsables de la protéolyse neutre calcium-dépendante. Les calpaïnes possèdent un domaine leur permettant d'interagir avec le calcium. Ce domaine, fortement homologue à la calmoduline, est dit calmodulin-like et présente des structures EF-Hand capables de lier les ions calcium. Le site actif des calpaïnes est constitué de trois acides aminés (triade catalytique): Cystéine (C), Histidine (H) et Asparagine (N). (fr) カルパイン（calpain, EC 3.4.22.52, EC 3.4.22.53）は、カルシウム依存的非リソソームシステインプロテアーゼファミリーに属するタンパク質である。哺乳類や他の多くの生物種で普遍的に発現している。カルパインはMEROPSデータベースにおいてclan CAのfamily C2を構成する。カルパインのタンパク質分解システムはカルパインプロテアーゼ、調節サブユニット (CAPN4)、そして内在性のカルパイン特異的阻害因子であるによって構成される。 (ja) As calpaínas representam uma família bem conservada de proteases de cisteína dependentes de cálcio. A atividade da calpaína in vivo é altamente regulada pelas (calpastatin), as calpastatinas inibem especificamente as calpaínas, não inibindo outras proteases de cisteína, através de suas interações com vários sítios das calpaínas. A má regulação das calpaínas pelas calpastatinas está associada a várias desordens patológicas humanas, incluindo distrofia muscular, câncer, doença de Alzheimer, injuria neurológica, diabetes e formação de catarata. Pesquisas recentes estão elucidando as estruturas primárias das calpaína 2 e do domínio regulatório calpaína 4, junto com a descoberta de novos meios de se regular a atividade das calpaínas providenciam novas oportunidades de se desenvolver novos tipos de inibidores da calpaínas. Muitas classes de inibidores do sítio ativo das calpaínas tem sido considerados efetivos contra as calpaínas, e estão sendo avaliados em modelos animais de doenças humanas. Entretanto uma limitação para o uso terapêutico dessa nova classe de inibidores é a especificidade que esses inibidores têm para proteoses de cisteína e outras enzimas proteolíticas. O desenvolvimento de novas classes de inibidores de calpaínas que interagem com domínios fora do sítio catalítico da calpaína podem trazer grande especificidade aos tratamentos terapêuticos. (pt) 钙蛋白酶（EC 3.4.22.52, EC 3.4.22.53）是一种蛋白质，属于钙依赖性、非溶酶体半胱氨酸蛋白酶（蛋白水解酶）家族，在哺乳动物和许多其他生物体中普遍表达。钙蛋白酶构成MEROPS数据库中蛋白酶族CA的C2家族。钙蛋白酶蛋白水解系统包括钙蛋白酶、小的调节亚基（也称为CAPN4）和内源性钙蛋白酶特异性抑制剂，。 (zh) |
| dbo:symbol | Calpain |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_1mdw_EBI.jpg?width=300 |
| dbo:wikiPageExternalLink | https://www.youtube.com/watch%3Fv=M1Jh6A9Xy1A http://ag.arizona.edu/calpains/ https://web.archive.org/web/20110626031221/http:/www.calpain.org/ https://web.archive.org/web/20110722012929/http:/cmkb.cellmigration.org/report.cgi%3Freport=fam_overview&fam_acc=cf00000447 https://web.archive.org/web/20141211173306/http:/www.cellmigration.org/index.shtml |
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| dbo:wikiPageLength | 23286 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1117047488 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Calcium dbr:Calmodulin dbr:Catalyst dbr:Cataract dbr:Protein_kinase_A dbr:Plasma_membrane dbr:Peptide dbr:Cytoskeleton dbr:Valine dbr:CAPN10 dbr:CAPN5 dbr:Depolarization dbc:Protein_families dbr:Memory dbr:Neuron dbr:The_Proteolysis_Map dbr:Proteolysis dbr:Brain dbr:Apoptosis dbr:Leucine dbr:MEROPS dbr:Calcium_in_biology dbr:Calpastatin dbc:Penta-EF-hand_proteins dbr:Dendrite dbr:Papain dbr:CAPN1 dbr:CAPN2 dbr:CAPN3 dbr:CAPN6 dbr:CAPN8 dbr:CAPN9 dbr:CAPNS1 dbr:Cell_(biology) dbr:Cell_body dbr:Cerebrovascular_accident dbr:Traumatic_brain_injury dbr:Tyrosine dbr:Ion_channel dbr:Long-term_potentiation dbr:Alkaline_phosphatase dbr:Amino_acid dbc:EC_3.4.22 dbr:Cysteine_protease dbr:EDANS dbr:Alzheimer's_disease dbr:PH dbr:Papaya dbr:Cell_adhesion_molecule dbr:Cell_cycle dbr:Cell_fusion dbr:Diffuse_axonal_injury dbr:Ischemic_cascade dbr:Fluorogenic dbr:Protein_dimer dbr:Isoform dbr:Protease dbr:Isoleucine dbc:Proteases dbr:Blood_vessel dbr:Tertiary_structure dbr:Tissue_(biology) dbr:Axon dbr:Phenylalanine dbr:Sodium dbr:Hydrophobic dbr:Necrosis dbr:Cathepsin dbr:Microtubule dbr:Microtubule-associated_protein dbr:Neurofilament dbr:Sodium_channel dbr:Cell_surface_receptors dbr:Lysosome dbr:Spectrin dbr:Skeletal_muscle dbr:Lens_of_the_eye dbr:Cell_motility dbr:Clan_CA dbr:Millimole dbr:Glial_cell dbr:Myoblast dbr:Clotting dbr:Primary_structure dbr:Splice_variant dbr:AK275 dbr:CAPN11 dbr:CAPN12 dbr:CAPN13 dbr:CAPN14 dbr:CAPN17 dbr:CAPN7 dbr:CAPNS2 dbr:Cardiac_contractile_dysfunction dbr:DABCYL dbr:MDL28170 dbr:SOLH |
| dbp:caption | Crystal structure of the peptidase core of Calpain II. (en) |
| dbp:casNumber | 689772 (xsd:integer) 702693 (xsd:integer) |
| dbp:date | August 2017 (en) |
| dbp:ecNumber | 3.400000 (xsd:double) |
| dbp:interpro | IPR001300 (en) |
| dbp:iubmbEcNumber | 3 (xsd:integer) |
| dbp:merops | 2.0 (dbd:nicaraguanCórdoba) |
| dbp:name | Calpain (en) calpain-1 (en) calpain-2 (en) |
| dbp:pdb | A:55-354; B:55-354; A:55-354; B:55-354; A:55-353; B:45-344; A:45-344; L:45-344; L:45-344; A:42-337 (en) |
| dbp:pfam | PF00648 (en) |
| dbp:pfamClan | CL0125 (en) |
| dbp:prosite | PDOC50203 (en) |
| dbp:reason | cardiac calpain not subject of citation (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:smart | CysPc (en) |
| dbp:symbol | Calpain (en) |
| dbp:wikiPageUsesTemplate | dbt:Cite_book dbt:Cite_journal dbt:EC_number dbt:Enzyme dbt:Enzymes dbt:IPAc-en dbt:Infobox_protein_family dbt:Irrelevant_citation dbt:MeshName dbt:Portal_bar dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:PDB2 dbt:Cysteine_proteases dbt:Calcium_signaling |
| dct:subject | dbc:Protein_families dbc:Penta-EF-hand_proteins dbc:EC_3.4.22 dbc:Proteases |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 yago:WikicatProteinFamilies |
| rdfs:comment | A calpain (/ˈkælpeɪn/; EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin. (en) Las calpaínas (EC 3.4.22.52, EC 3.4.22.53) son , no lisosomales, cuya actividad, de tipo papaína, es dependiente de calcio. Estas enzimas son responsables de la proteólisis neutra calcio-dependiente, en virtud de un dominio de unión a calcio. Este dominio se denomina calmodulin-like por ser altamente homólogo a la calmodulina, presentando las estructuras típicas manos EF de unión a ion calcio. El centro activo de las calpaínas está compuesto de una tríada catalítica formada por cisteína (C), histidina (H) y Asparagina (N). (es) Les calpaïnes (EC 3.4.22.52, EC 3.4.22.53) sont des protéases à cystéine, non-lysosomiales, dont l'activité, de type papaïne, est dépendante du calcium. Ces enzymes sont responsables de la protéolyse neutre calcium-dépendante. Les calpaïnes possèdent un domaine leur permettant d'interagir avec le calcium. Ce domaine, fortement homologue à la calmoduline, est dit calmodulin-like et présente des structures EF-Hand capables de lier les ions calcium. Le site actif des calpaïnes est constitué de trois acides aminés (triade catalytique): Cystéine (C), Histidine (H) et Asparagine (N). (fr) カルパイン（calpain, EC 3.4.22.52, EC 3.4.22.53）は、カルシウム依存的非リソソームシステインプロテアーゼファミリーに属するタンパク質である。哺乳類や他の多くの生物種で普遍的に発現している。カルパインはMEROPSデータベースにおいてclan CAのfamily C2を構成する。カルパインのタンパク質分解システムはカルパインプロテアーゼ、調節サブユニット (CAPN4)、そして内在性のカルパイン特異的阻害因子であるによって構成される。 (ja) 钙蛋白酶（EC 3.4.22.52, EC 3.4.22.53）是一种蛋白质，属于钙依赖性、非溶酶体半胱氨酸蛋白酶（蛋白水解酶）家族，在哺乳动物和许多其他生物体中普遍表达。钙蛋白酶构成MEROPS数据库中蛋白酶族CA的C2家族。钙蛋白酶蛋白水解系统包括钙蛋白酶、小的调节亚基（也称为CAPN4）和内源性钙蛋白酶特异性抑制剂，。 (zh) As calpaínas representam uma família bem conservada de proteases de cisteína dependentes de cálcio. A atividade da calpaína in vivo é altamente regulada pelas (calpastatin), as calpastatinas inibem especificamente as calpaínas, não inibindo outras proteases de cisteína, através de suas interações com vários sítios das calpaínas. A má regulação das calpaínas pelas calpastatinas está associada a várias desordens patológicas humanas, incluindo distrofia muscular, câncer, doença de Alzheimer, injuria neurológica, diabetes e formação de catarata. Pesquisas recentes estão elucidando as estruturas primárias das calpaína 2 e do domínio regulatório calpaína 4, junto com a descoberta de novos meios de se regular a atividade das calpaínas providenciam novas oportunidades de se desenvolver novos tipo (pt) |
| rdfs:label | Calpain (en) Calpaína (es) Calpaïne (fr) カルパイン (ja) Calpaína (pt) 钙蛋白酶 (zh) |
| owl:sameAs | freebase:Calpain yago-res:Calpain wikidata:Calpain dbpedia-es:Calpain dbpedia-fr:Calpain dbpedia-gl:Calpain dbpedia-ja:Calpain http://lt.dbpedia.org/resource/Kalpainas dbpedia-pt:Calpain dbpedia-sr:Calpain dbpedia-zh:Calpain https://global.dbpedia.org/id/2ipUm |
| prov:wasDerivedFrom | wikipedia-en:Calpain?oldid=1117047488&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PDB_1mdw_EBI.jpg |
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