| dbo:abstract |
The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells. PHLPP dephosphorylates Ser-473 (the hydrophobic motif) in Akt, thus partially inactivating the kinase. In addition, PHLPP dephosphorylates conventional and novel members of the protein kinase C family at their hydrophobic motifs, corresponding to Ser-660 in PKCβII. (en) Les PHLPP (de l'anglais : PH domain and Leucine rich repeat Protein Phosphatase) sont une famille de protéines de type phosphatase, permettant l'inactivation des protéine Akt. Cette famille est composée de trois isoformes : PHLPP1α, PHLPP1β (issu du même gène PHLPP1 mais épissée différemment) et PHLPP2. (fr) |
| dbo:arm |
q |
| dbo:band |
22.2 21.32 |
| dbo:chromosome |
16 18 |
| dbo:ecNumber |
3.1.3.16 |
| dbo:entrezgene |
23035 23239 |
| dbo:hgncid |
29149 20610 |
| dbo:omim |
609396 (xsd:integer) 611066 (xsd:integer) |
| dbo:refseq |
NM_015020 XM_166290 |
| dbo:symbol |
PHLPP PHLPP1, PLEKHE1 PHLPP2 PHLPPL |
| dbo:uniprot |
O60346 Q6ZVD8 |
| dbo:wikiPageID |
10292285 (xsd:integer) |
| dbo:wikiPageLength |
12054 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1118754945 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Insulin_receptor dbr:Insulin_resistance dbr:Leucine-rich_repeat dbc:EC_3.1.3 dbr:Chronic_myelogenous_leukemia dbr:Enzyme dbr:Gleevec dbr:Protein_synthesis dbr:Apoptosis dbr:Magnesium dbr:Manganese dbr:Phosphoinositide-dependent_kinase-1 dbr:Protein_kinase_C dbr:Protein_kinase dbr:G_protein-coupled_receptor dbr:PDZ_domain dbr:AKT1 dbr:AKT2 dbr:AKT3 dbc:Signal_transduction dbr:Diabetes dbr:Diacylglycerol dbr:Serine dbr:Loss_of_heterozygosity dbr:Pleckstrin_homology_domain dbr:PHLPPL dbr:PHLPP_(gene) dbr:N-terminus dbr:AKT dbr:Oncogene dbr:Phosphatase dbr:Phosphomimetics dbr:Retrovirus dbr:Bcr-abl_fusion_protein dbr:PIP3 dbr:Activation_loop dbr:Ras_(protein) |
| dbp:altsymbols |
PHLPP2 (en) PHLPP1, PLEKHE1 (en) |
| dbp:arm |
q (en) |
| dbp:band |
21.320000 (xsd:double) 22.200000 (xsd:double) |
| dbp:chromosome |
16 (xsd:integer) 18 (xsd:integer) |
| dbp:ecnumber |
3.100000 (xsd:double) |
| dbp:entrezgene |
23035 (xsd:integer) 23239 (xsd:integer) |
| dbp:hgncid |
20610 (xsd:integer) 29149 (xsd:integer) |
| dbp:name |
dbr:PHLPPL dbr:PHLPP_(gene) |
| dbp:omim |
609396 (xsd:integer) 611066 (xsd:integer) |
| dbp:refseq |
NM_015020 (en) XM_166290 (en) |
| dbp:symbol |
dbr:PHLPPL dbr:PHLPP_(gene) |
| dbp:uniprot |
O60346 (en) Q6ZVD8 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Citation_needed dbt:EC_number dbt:Enzymes dbt:Esterases dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Infobox_protein |
| dct:subject |
dbc:EC_3.1.3 dbc:Signal_transduction |
| gold:hypernym |
dbr:Pair |
| rdf:type |
owl:Thing dbo:Place dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 dbo:Protein umbel-rc:ProteinMolecule |
| rdfs:comment |
Les PHLPP (de l'anglais : PH domain and Leucine rich repeat Protein Phosphatase) sont une famille de protéines de type phosphatase, permettant l'inactivation des protéine Akt. Cette famille est composée de trois isoformes : PHLPP1α, PHLPP1β (issu du même gène PHLPP1 mais épissée différemment) et PHLPP2. (fr) The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells. PHLPP dephosphorylates Ser-473 (the hydrophobic motif) in Akt, thus partially inactivating the kinase. (en) |
| rdfs:label |
PHLPP (en) PHLPP (fr) |
| owl:sameAs |
freebase:PHLPP wikidata:PHLPP dbpedia-fr:PHLPP https://global.dbpedia.org/id/4sZxF |
| prov:wasDerivedFrom |
wikipedia-en:PHLPP?oldid=1118754945&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:PHLPP |
| foaf:name |
PH domain and leucine rich repeat protein phosphatase-like (en) PH domain and leucine-rich repeat protein phosphatase (en) |
| is dbo:academicDiscipline of |
dbr:Alexandra_Newton |
| is dbo:wikiPageRedirects of |
dbr:PHLPP-1 dbr:PHLPP2 dbr:Phlpp1 |
| is dbo:wikiPageWikiLink of |
dbr:Alexandra_Newton dbr:Protein_kinase_B dbr:Maspin dbr:Akt/PKB_signaling_pathway dbr:Serpin dbr:Pleckstrin_homology_domain dbr:PHLPPL dbr:PHLPP_(gene) dbr:PHLPP-1 dbr:PHLPP2 dbr:Phlpp1 |
| is foaf:primaryTopic of |
wikipedia-en:PHLPP |