PPAP2B (original) (raw)
Lipid phosphate phosphohydrolase 3 (LPP3), also known as phospholipid phosphatase 3 (PLPP3) and phosphatidic acid phosphatase type 2B (PAP-2b or PPAP2B), is an enzyme that in humans is encoded by the PPAP2B gene on chromosome 1. It is ubiquitously expressed in many tissues and cell types. LPP3 is a cell-surface glycoprotein that hydrolyzes extracellular lysophosphatidic acid (LPA) and short-chain phosphatidic acid. Its function allows it to regulate vascular and embryonic development by inhibiting LPA signaling, which is associated with a wide range of human diseases, including cardiovascular disease and cancer, as well as developmental defects. The PPAP2B gene also contains one of 27 loci associated with increased risk of coronary artery disease.
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| dbo:abstract | Lipid phosphate phosphohydrolase 3 (LPP3), also known as phospholipid phosphatase 3 (PLPP3) and phosphatidic acid phosphatase type 2B (PAP-2b or PPAP2B), is an enzyme that in humans is encoded by the PPAP2B gene on chromosome 1. It is ubiquitously expressed in many tissues and cell types. LPP3 is a cell-surface glycoprotein that hydrolyzes extracellular lysophosphatidic acid (LPA) and short-chain phosphatidic acid. Its function allows it to regulate vascular and embryonic development by inhibiting LPA signaling, which is associated with a wide range of human diseases, including cardiovascular disease and cancer, as well as developmental defects. The PPAP2B gene also contains one of 27 loci associated with increased risk of coronary artery disease. (en) PLPP3 (англ. Phospholipid phosphatase 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 311 амінокислот, а молекулярна маса — 35 116. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до гідролаз, фосфопротеїнів. Локалізований у клітинній мембрані, мембрані, апараті гольджі. (uk) |
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| dbo:wikiPageWikiLink | dbr:Cancer dbr:Endothelium dbr:Epithelium dbr:MicroRNA dbr:Plasma_membrane dbr:Metabolic_syndrome dbr:Beta-catenin dbr:Vascular dbr:Dephosphorylation dbr:Insulin_resistance dbr:Integral_membrane_protein dbr:Protein_isoform dbr:Oligomer dbr:PPAP2B dbr:Phosphatidic_acid dbr:Embryonic_development dbr:Enzyme dbr:Gene dbr:Coronary_artery_disease dbr:Lysophosphatidic_acid dbr:Statin dbr:Embryonic_stem_cell dbr:Phosphatidic_acid_phosphatase dbr:Phospholipid dbr:Substrate_(biology) dbr:TCF/LEF_family dbr:Acute_coronary_syndrome dbr:Catalytic_site dbr:Locus_(genetics) dbr:Extracellular dbr:Cardiovascular_disease dbr:Cell_membrane dbr:Glycoprotein dbr:KLF2 dbr:Atherosclerosis dbr:Hydrolysis dbr:Diabetes_mellitus dbr:Fibrosis dbr:Embryogenesis dbr:Chromosome_1_(human) dbr:Wnt_signaling_pathway dbr:Exon dbr:Transmembrane_domain dbr:Phosphatase dbr:Cell-surface dbr:Genome-wide_Association_Studies dbr:Lumen_(biology) |
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| rdfs:comment | Lipid phosphate phosphohydrolase 3 (LPP3), also known as phospholipid phosphatase 3 (PLPP3) and phosphatidic acid phosphatase type 2B (PAP-2b or PPAP2B), is an enzyme that in humans is encoded by the PPAP2B gene on chromosome 1. It is ubiquitously expressed in many tissues and cell types. LPP3 is a cell-surface glycoprotein that hydrolyzes extracellular lysophosphatidic acid (LPA) and short-chain phosphatidic acid. Its function allows it to regulate vascular and embryonic development by inhibiting LPA signaling, which is associated with a wide range of human diseases, including cardiovascular disease and cancer, as well as developmental defects. The PPAP2B gene also contains one of 27 loci associated with increased risk of coronary artery disease. (en) PLPP3 (англ. Phospholipid phosphatase 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 311 амінокислот, а молекулярна маса — 35 116. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | PPAP2B (en) PLPP3 (uk) |
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