Perindopril (original) (raw)
بيريندوبريل هو إحدى مثبطات الإنزيم المحول للأنجيوتنسين والتي تقوم بتثبيط الإنزيم ACE وتستخدم في حالات قصور القلب وفرط ضغط الدم واحتشاء عضل القلب واعتلال الكلى السكري.
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| dbo:abstract | بيريندوبريل هو إحدى مثبطات الإنزيم المحول للأنجيوتنسين والتي تقوم بتثبيط الإنزيم ACE وتستخدم في حالات قصور القلب وفرط ضغط الدم واحتشاء عضل القلب واعتلال الكلى السكري. (ar) Perindopril ist eine chemische Verbindung die strukturell mit der Verbindung Enalapril verwandt ist und wie diese ein ACE-Hemmer ist. (de) Le périndopril est un inhibiteur de l'enzyme de conversion de l’angiotensine (IEC). Il est prescrit dans le cas d'hypertension artérielle, de maladie coronaire stable et d'insuffisance cardiaque. Il inhibe la métabolisation de l'angiotensine I en angiotensine II. Cette protéine possède un puissant pouvoir vasoconstricteur sur les artérioles et dégrade la bradykinine vasodilatatrice. Ainsi une production diminuée d'angiotensine II donne lieu à une vasodilatation donc une diminution des résistances vasculaires périphériques (RVP) et par conséquent une baisse de la pression artérielle. Le brevet du périndopril est tombé en 2003. En 2014, les laboratoires Servier et quatre laboratoires de génériques ont été condamnés à une amende de 428 millions d’euros par la commission européenne pour entrave à la fabrication d’un générique de sa molécule ; Servier a fait appel de ce jugement. (fr) Perindopril is a medication used to treat high blood pressure, heart failure, or stable coronary artery disease. As a long-acting ACE inhibitor, it works by relaxing blood vessels and decreasing blood volume. As a prodrug, perindopril is hydrolyzed in the liver to its active metabolite, perindoprilat. It was patented in 1980 and approved for medical use in 1988. Perindopril is taken in the form of perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (Aceon). Both forms are therapeutically equivalent and interchangeable, but the dose prescribed to achieve the same effect differs between the two forms. It is also often combined with another medication, sometimes in the same tablet (see below). (en) ペリンドプリル（Perindopril）は長時間使用型アンジオテンシン変換酵素阻害薬のひとつ。日本での商品名は「コバシル」(フランスのが創成。日本で当初は第一製薬が販売していたが、2008年第一三共より協和発酵へ販売移管、2011年現在は協和発酵キリン販売) (ja) Il perindopril o perindopril arginina (INN) è un Ace inibitore a lunga durata d'azione (commercializzato con il nome di Coversyl, Procaptan e Aceon sia in Europa che in USA). È utilizzato nella terapia dell'ipertensione arteriosa, dello scompenso cardiaco e della cardiopatia ischemica. È anche a disposizione sotto forma di perindopril erbumina; le due forme sono state definite equivalenti e pertanto possono essere utilizzate indistintamente nella pratica clinica, producendo gli stessi effetti terapeutici. Si sottolinea che i dosaggi necessari per il raggiungimento di un buon controllo pressorio, possono subire variazioni legate al diverso peso molecolare delle due forme. (it) Peryndopryl – organiczny związek chemiczny, lek z grupy inhibitorów konwertazy angiotensyny, stosowany przede wszystkim w leczeniu nadciśnienia tętniczego oraz niewydolności serca. Podlega metabolizmowi do związków biologicznie czynnych. Jego czynny metabolit to peryndoprylat. (pl) Perindopril är ett läkemedel som används för behandling av högt blodtryck. Läkemedlet tillhör läkemedelsgruppen ACE-hämmare och verkar genom att förbättra blodflödet. Detta åstadkoms genom att hämma de ämnen som förekommer naturligt i kroppen, vilka får blodkärlen att dra sig samman. Perindopril kan ge upphov till vissa biverkningar såsom hosta, yrsel, diarré, huvudvärk, magont, orolig mage samt en svaghetskänsla. Läkemedlet kan även ge upphov till allvarligare biverkningar såsom heshet, svårigheter att svälja eller andas, svimningsanfall, oregelbunden eller förhöjd puls, feber, halsont, frossa och andra tecken på infektion samt svullnad i ben, anklar, fötter, händer, läppar, ögon, tunga, hals eller ansikte. (sv) Perindopril é um medicamento do tipo inibidor da enzima de conversão da angiotensina (IECA) utilizado no tratamento de hipertensão arterial. (pt) Таблетки. (uk) Периндоприл — лекарственное средство, ингибитор ангиотензинпревращающего фермента (АПФ). (ru) |
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| rdfs:comment | بيريندوبريل هو إحدى مثبطات الإنزيم المحول للأنجيوتنسين والتي تقوم بتثبيط الإنزيم ACE وتستخدم في حالات قصور القلب وفرط ضغط الدم واحتشاء عضل القلب واعتلال الكلى السكري. (ar) Perindopril ist eine chemische Verbindung die strukturell mit der Verbindung Enalapril verwandt ist und wie diese ein ACE-Hemmer ist. (de) ペリンドプリル（Perindopril）は長時間使用型アンジオテンシン変換酵素阻害薬のひとつ。日本での商品名は「コバシル」(フランスのが創成。日本で当初は第一製薬が販売していたが、2008年第一三共より協和発酵へ販売移管、2011年現在は協和発酵キリン販売) (ja) Il perindopril o perindopril arginina (INN) è un Ace inibitore a lunga durata d'azione (commercializzato con il nome di Coversyl, Procaptan e Aceon sia in Europa che in USA). È utilizzato nella terapia dell'ipertensione arteriosa, dello scompenso cardiaco e della cardiopatia ischemica. È anche a disposizione sotto forma di perindopril erbumina; le due forme sono state definite equivalenti e pertanto possono essere utilizzate indistintamente nella pratica clinica, producendo gli stessi effetti terapeutici. Si sottolinea che i dosaggi necessari per il raggiungimento di un buon controllo pressorio, possono subire variazioni legate al diverso peso molecolare delle due forme. (it) Peryndopryl – organiczny związek chemiczny, lek z grupy inhibitorów konwertazy angiotensyny, stosowany przede wszystkim w leczeniu nadciśnienia tętniczego oraz niewydolności serca. Podlega metabolizmowi do związków biologicznie czynnych. Jego czynny metabolit to peryndoprylat. (pl) Perindopril é um medicamento do tipo inibidor da enzima de conversão da angiotensina (IECA) utilizado no tratamento de hipertensão arterial. (pt) Таблетки. (uk) Периндоприл — лекарственное средство, ингибитор ангиотензинпревращающего фермента (АПФ). (ru) Le périndopril est un inhibiteur de l'enzyme de conversion de l’angiotensine (IEC). Il est prescrit dans le cas d'hypertension artérielle, de maladie coronaire stable et d'insuffisance cardiaque. Il inhibe la métabolisation de l'angiotensine I en angiotensine II. Cette protéine possède un puissant pouvoir vasoconstricteur sur les artérioles et dégrade la bradykinine vasodilatatrice. Ainsi une production diminuée d'angiotensine II donne lieu à une vasodilatation donc une diminution des résistances vasculaires périphériques (RVP) et par conséquent une baisse de la pression artérielle. (fr) Perindopril is a medication used to treat high blood pressure, heart failure, or stable coronary artery disease. As a long-acting ACE inhibitor, it works by relaxing blood vessels and decreasing blood volume. As a prodrug, perindopril is hydrolyzed in the liver to its active metabolite, perindoprilat. It was patented in 1980 and approved for medical use in 1988. (en) Perindopril är ett läkemedel som används för behandling av högt blodtryck. Läkemedlet tillhör läkemedelsgruppen ACE-hämmare och verkar genom att förbättra blodflödet. Detta åstadkoms genom att hämma de ämnen som förekommer naturligt i kroppen, vilka får blodkärlen att dra sig samman. (sv) |
| rdfs:label | بيريندوبريل (ar) Perindopril (de) Périndopril (fr) Perindopril (it) ペリンドプリル (ja) Perindopril (en) Peryndopryl (pl) Perindopril (pt) Периндоприл (ru) Perindopril (sv) Периндоприл (uk) |
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