| dbo:abstract |
Imepitoin ist eine chemische Verbindung, die aufgrund ihrer antiepileptischen und angstlösenden (anxiolytischen) Wirkung bei Hunden zur Behandlung der idiopathischen Epilepsie und von Geräuschangst eingesetzt wird. Chemisch handelt es sich um einen Abkömmling (Derivat) des Morpholins und des . (de) Imepitoin (INN), sold under the brand name Pexion, is an anticonvulsant which is used in veterinary medicine in Europe to treat epilepsy in dogs. It was recently approved in the United States. The drug also has anxiolytic effects. It was originally developed to treat epilepsy in humans, but clinical trials were terminated upon findings of unfavorable metabolic differences in smokers and non-smokers. Imepitoin acts as a low-affinity (4,350–5,140 nM; relative to Ki = 6.8 nM for diazepam and Ki = 1.7 nM for clonazepam) partial agonist of the benzodiazepine site of the GABAA receptor (up to 12–21% of the maximal potentiation of diazepam, a full agonist of this site). It is the first partial agonist to be approved for the treatment of epilepsy. The drug also dose-dependently blocks voltage-gated calcium channels. It is not a benzodiazepine; instead, it is an imidazolone, and bears some structural similarities to hydantoin anticonvulsants like ethotoin and phenytoin. (en) L'imépitoïne est un agoniste partiel des récepteurs GABAA, utilisé en médecine vétérinaire comme anticonvulsivant pour les chiens atteints d'épilepsie génétique. (fr) |
| dbo:alternativeName |
Pexion (en) |
| dbo:casNumber |
188116-07-6 |
| dbo:chEMBL |
204240 |
| dbo:fdaUniiCode |
19V39682LI |
| dbo:pubchem |
3083511 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Imepitoin.svg?width=300 |
| dbo:wikiPageID |
55269008 (xsd:integer) |
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4577 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
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| dbo:wikiPageWikiLink |
dbr:Epilepsy dbr:Partial_agonist dbr:Anticonvulsant dbr:Hydantoin dbr:United_States dbr:Veterinary_medicine dbr:Structural_analog dbc:Chloroarenes dbc:GABAA_receptor_positive_allosteric_modulators dbr:Chemical_structure dbr:Oral_administration dbr:Clonazepam dbr:Full_agonist dbr:Anxiolytic dbr:Clinical_trial dbr:GABAA_receptor dbc:Anxiolytics dbc:Calcium_channel_blockers dbr:Ethotoin dbr:Europe dbr:Nonbenzodiazepine dbc:Anticonvulsants dbc:Morpholines dbc:Veterinary_drugs dbr:Affinity_(pharmacology) dbr:Diazepam dbr:Phenytoin dbr:Metabolism dbr:Channel_blocker dbr:Separation_anxiety_in_dogs dbr:Smoking dbr:Voltage-gated_calcium_channel dbr:Imidazolone dbr:Benzodiazepine_site |
| dbp:atcPrefix |
N03 (en) |
| dbp:atcSuffix |
AX90 (en) |
| dbp:atcvet |
yes (en) |
| dbp:c |
13 (xsd:integer) |
| dbp:casNumber |
188116 (xsd:integer) |
| dbp:chembl |
204240 (xsd:integer) |
| dbp:chemspiderid |
2340703 (xsd:integer) |
| dbp:cl |
1 (xsd:integer) |
| dbp:h |
14 (xsd:integer) |
| dbp:iupacName |
3 (xsd:integer) |
| dbp:n |
3 (xsd:integer) |
| dbp:o |
2 (xsd:integer) |
| dbp:pubchem |
3083511 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Oral_administration |
| dbp:smiles |
C1COCCN1C2=NCNC3=CC=CCl (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
IQHYCZKIFIHTAI-UHFFFAOYSA-N (en) |
| dbp:synonyms |
AWD 131-138; ELB-138 (en) |
| dbp:tradename |
Pexion (en) |
| dbp:unii |
19 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:Reflist dbt:Short_description dbt:When dbt:Abbrlink dbt:Anxiolytics dbt:GABAA_receptor_positive_allosteric_modulators dbt:Ion_channel_modulators dbt:Anticonvulsant-stub dbt:Anticonvulsants |
| dct:subject |
dbc:Chloroarenes dbc:GABAA_receptor_positive_allosteric_modulators dbc:Anxiolytics dbc:Calcium_channel_blockers dbc:Anticonvulsants dbc:Morpholines dbc:Veterinary_drugs |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment |
Imepitoin ist eine chemische Verbindung, die aufgrund ihrer antiepileptischen und angstlösenden (anxiolytischen) Wirkung bei Hunden zur Behandlung der idiopathischen Epilepsie und von Geräuschangst eingesetzt wird. Chemisch handelt es sich um einen Abkömmling (Derivat) des Morpholins und des . (de) L'imépitoïne est un agoniste partiel des récepteurs GABAA, utilisé en médecine vétérinaire comme anticonvulsivant pour les chiens atteints d'épilepsie génétique. (fr) Imepitoin (INN), sold under the brand name Pexion, is an anticonvulsant which is used in veterinary medicine in Europe to treat epilepsy in dogs. It was recently approved in the United States. The drug also has anxiolytic effects. It was originally developed to treat epilepsy in humans, but clinical trials were terminated upon findings of unfavorable metabolic differences in smokers and non-smokers. (en) |
| rdfs:label |
Imepitoin (de) Imépitoïne (fr) Imepitoin (en) |
| owl:sameAs |
wikidata:Imepitoin dbpedia-de:Imepitoin dbpedia-fr:Imepitoin dbpedia-vi:Imepitoin https://global.dbpedia.org/id/vBLm |
| prov:wasDerivedFrom |
wikipedia-en:Imepitoin?oldid=1110780499&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Imepitoin.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Imepitoin |
| is dbo:wikiPageRedirects of |
dbr:Pexion dbr:ELB-138 dbr:ELB138 dbr:ELB_138 dbr:AWD-131-138 dbr:AWD131-138 dbr:AWD_131-138 |
| is dbo:wikiPageWikiLink of |
dbr:Epilepsy dbr:Epilepsy_in_animals dbr:Boehringer_Ingelheim dbr:ATC_code_N03 dbr:Pexion dbr:Separation_anxiety_in_dogs dbr:List_of_drugs:_Im–In dbr:ELB-138 dbr:ELB138 dbr:ELB_138 dbr:AWD-131-138 dbr:AWD131-138 dbr:AWD_131-138 |
| is foaf:primaryTopic of |
wikipedia-en:Imepitoin |
