Pimobendan (original) (raw)
Pimobendan ist ein Arzneistoff, der als Herz-Kreislaufmittel nur für Tiere zugelassen ist. Es stellt neben Levosimendan den bisher einzigen Vertreter aus der Gruppe der Calcium-Sensitizer dar.
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| dbo:abstract | Pimobendan ist ein Arzneistoff, der als Herz-Kreislaufmittel nur für Tiere zugelassen ist. Es stellt neben Levosimendan den bisher einzigen Vertreter aus der Gruppe der Calcium-Sensitizer dar. (de) Le pimobendane est une molécule un dérivée du , ayant une action inotrope positive et possédant de puissantes propriétés vasodilatatrices. (fr) Pimobendan (INN, or pimobendane; tradenames Vetmedin, Acardi) is a veterinary medication. It is a calcium sensitizer and a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilator effects. Pimobendan is used in the management of heart failure in dogs, most commonly caused by myxomatous mitral valve disease (also previously known as ), or dilated cardiomyopathy. Research has shown that as a monotherapy, pimobendan increases survival time and improves quality of life in canine patients with congestive heart failure secondary to mitral valve disease when compared with benazepril, an ACE inhibitor. However, in clinical practice, it is often used in conjunction with an ACE inhibitor like enalapril or benazepril. Under the trade name Acardi, it is available for human use in Japan. (en) Il pimobendan è un agente positivo, con effetto anche vasodilatatore, risultato efficace nel trattamento dell'insufficienza cardiaca nel cane. È utilizzato nel trattamento dello scompenso cardiaco congestizio del cane, dovuto a cardiomiopatia dilatativa o insufficienza valvolare che causa rigurgito della valvola mitralica e/o della valvola tricuspide. In Giappone, è indicato anche per l'uso umano. (it) Pimobendan – organiczny związek chemiczny, lek zwiększający wrażliwość mięśnia sercowego na wapń, działający przez to dodatnio inotropowo i rozszerzający naczynia. Jest również selektywnym inhibitorem fosfodiesterazy-3 (PDE3). Pimobendan jest stosowany w leczeniu niewydolności serca u psów, najczęściej powodowanej przez śluzowate zwyrodnienie płatków zastawki mitralnej, lub w przebiegu kardiomiopatii rozstrzeniowej. Przeprowadzono badania u ludzi, w których pimobendan zwiększał przeżycie i poprawiał jakość życia u pacjentów z zastoinową niewydolnością serca wtórną do dysfunkcji zastawki mitralnej w porównaniu z benazeprylem, inhibitorem konwertazy angiotensyny. Obecnie dopuszczony jest do stosowania u ludzi jedynie w Japonii, gdzie jest w obrocie pod nazwą handlową Acardi. (pl) |
| dbo:bioavailability | 60.000000 (xsd:float) |
| dbo:casNumber | 74150-27-9 |
| dbo:chEMBL | 24646 |
| dbo:fdaUniiCode | 34AP3BBP9T |
| dbo:kegg | D01133 |
| dbo:pubchem | 4823 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Pimobendan_skeletal.svg?width=300 |
| dbo:wikiPageExternalLink | http://www.vetmedin.com/ http://cavalierhealth.net/mitral_valve_disease.htm%23A_Few_Words https://pubchem.ncbi.nlm.nih.gov/compound/20516902 https://pubchem.ncbi.nlm.nih.gov/compound/20516917 https://pharmaceutical-substances.thieme.com/ps/search-results%3FdocUri=KD-16-0105 |
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| dbp:atcSuffix | CE90 (en) |
| dbp:atcvet | yes (en) |
| dbp:bioavailability | 60 (xsd:integer) |
| dbp:c | 19 (xsd:integer) |
| dbp:casNumber | 74150 (xsd:integer) |
| dbp:chembl | 24646 (xsd:integer) |
| dbp:chemspiderid | 4657 (xsd:integer) |
| dbp:chirality | dbr:Racemic_mixture |
| dbp:eliminationHalfLife | 1440.0 (dbd:second) |
| dbp:excretion | In feces (en) |
| dbp:h | 18 (xsd:integer) |
| dbp:iupacName | -6 (xsd:integer) |
| dbp:kegg | D01133 (en) |
| dbp:legalStatus | Rx-only (en) |
| dbp:n | 4 (xsd:integer) |
| dbp:o | 2 (xsd:integer) |
| dbp:pubchem | 4823 (xsd:integer) |
| dbp:routesOfAdministration | Oral (en) |
| dbp:smiles | CC1CCNN=C1C2=CC3=CN=CC4=CC=COC (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | GLBJJMFZWDBELO-UHFFFAOYSA-N (en) |
| dbp:unii | 34 (xsd:integer) |
| dbp:verifiedfields | changed (en) |
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| dbp:watchedfields | changed (en) |
| dbp:width | 200 (xsd:integer) |
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| gold:hypernym | dbr:Medication |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatVasodilators yago:WikicatVeterinaryDrugs yago:WikicatPDE3Inhibitors yago:Agent109190918 yago:Agent114778436 yago:CausalAgent100007347 yago:Dilator103198383 yago:Drug103247620 yago:Inhibitor114724436 yago:Matter100020827 yago:PhysicalEntity100001930 yago:WikicatInotropicAgents dbo:Drug yago:Substance100020090 yago:Vasodilator104522904 yago:WikicatPhosphodiesteraseInhibitors umbel-rc:DrugProduct |
| rdfs:comment | Pimobendan ist ein Arzneistoff, der als Herz-Kreislaufmittel nur für Tiere zugelassen ist. Es stellt neben Levosimendan den bisher einzigen Vertreter aus der Gruppe der Calcium-Sensitizer dar. (de) Le pimobendane est une molécule un dérivée du , ayant une action inotrope positive et possédant de puissantes propriétés vasodilatatrices. (fr) Il pimobendan è un agente positivo, con effetto anche vasodilatatore, risultato efficace nel trattamento dell'insufficienza cardiaca nel cane. È utilizzato nel trattamento dello scompenso cardiaco congestizio del cane, dovuto a cardiomiopatia dilatativa o insufficienza valvolare che causa rigurgito della valvola mitralica e/o della valvola tricuspide. In Giappone, è indicato anche per l'uso umano. (it) Pimobendan (INN, or pimobendane; tradenames Vetmedin, Acardi) is a veterinary medication. It is a calcium sensitizer and a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilator effects. (en) Pimobendan – organiczny związek chemiczny, lek zwiększający wrażliwość mięśnia sercowego na wapń, działający przez to dodatnio inotropowo i rozszerzający naczynia. Jest również selektywnym inhibitorem fosfodiesterazy-3 (PDE3). (pl) |
| rdfs:label | Pimobendan (de) Pimobendane (fr) Pimobendan (it) Pimobendan (en) Pimobendan (pl) |
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| prov:wasDerivedFrom | wikipedia-en:Pimobendan?oldid=1119947871&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Pimobendan_skeletal.svg wiki-commons:Special:FilePath/Pimobendan_synthesis.svg |
| foaf:homepage | http://www.vetmedin.com/ |
| foaf:isPrimaryTopicOf | wikipedia-en:Pimobendan |
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