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Pirarubicin (INN) is an anthracycline drug.An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (en) La pirarubicina (chiamata anche 4'-O-tetraidropiraniladriamicina)è un antineoplastico, appartenente alla classe delle antracicline, con struttura ed azione simili a quelle della doxorubicina. Il farmaco inibisce la sintesi del DNA e del RNA. La pirarubicina si intercala nella doppia elica del DNA ed inibisce le polimerasi degli acidi nucleici. (it) ピラルビシン（Pirarubicin、THP）はアントラサイクリン系の薬剤の一つであり、抗悪性腫瘍性抗生物質であるドキソルビシンのアナログである。ピラルビシンはDNAの隙間にインターカレートしてトポイソメラーゼIIを阻害し、結果としてDNAの複製や修復、RNAやタンパク質の合成を阻害する。ドキソルビシンよりも心毒性が低く、一部のドキソルビシン耐性細胞株に対して活性を示す。静脈内注射、動脈内注射等で用いられる。 (ja) |
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Pirarubicin (INN) is an anthracycline drug.An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (en) La pirarubicina (chiamata anche 4'-O-tetraidropiraniladriamicina)è un antineoplastico, appartenente alla classe delle antracicline, con struttura ed azione simili a quelle della doxorubicina. Il farmaco inibisce la sintesi del DNA e del RNA. La pirarubicina si intercala nella doppia elica del DNA ed inibisce le polimerasi degli acidi nucleici. (it) ピラルビシン（Pirarubicin、THP）はアントラサイクリン系の薬剤の一つであり、抗悪性腫瘍性抗生物質であるドキソルビシンのアナログである。ピラルビシンはDNAの隙間にインターカレートしてトポイソメラーゼIIを阻害し、結果としてDNAの複製や修復、RNAやタンパク質の合成を阻害する。ドキソルビシンよりも心毒性が低く、一部のドキソルビシン耐性細胞株に対して活性を示す。静脈内注射、動脈内注射等で用いられる。 (ja) |
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Pirarubicina (it) ピラルビシン (ja) Pirarubicin (en) |
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