| dbo:abstract |
Proadifen (SKF-525A) is a non-selective inhibitor of cytochrome P450 enzymes, preventing some types of drug metabolism. It is also an inhibitor of neuronal nitric oxide synthase (NOS), CYP-dependent (cytochrome P450-dependent) arachidonate metabolism, transmembrane calcium influx, and platelet thromboxane synthesis. Further documented effects include the blockade of ATP-sensitive inward rectifier potassium channel 8 (KIR6.1), and stimulation of endothelial cell prostacyclin production. Proadifen exerts apoptotic/anti-proliferate (tumour suppressing) effects in certain forms of cancer (HT-29 colon adenocarcinoma), believed to be caused by mediation of glycogen synthase kinase 3 β (GSK-3β). In the same study administration of proadifen was demonstrated to produce time- and dose-dependent phosphatidylserine externalization, caspase-3 activation and PARP cleavage. Intense upregulation of NAG-1 and ATF3 and downregulation of Mcl-1 and Egr-1 were also observed. Proadifen has been demonstrated to normally inhibit the nicotinic acetylcholine receptor (NAChR) and muscarinic acetylcholine receptor (MAChR) in rats. (en) |
| dbo:alternativeName |
SKF 525-A (en) |
| dbo:iupacName |
2-(Diethylamino)ethyl 2,2-diphenylpentanoate (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Proadifen.png?width=300 |
| dbo:wikiPageID |
25296374 (xsd:integer) |
| dbo:wikiPageLength |
3268 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1086023311 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbc:Cytochrome_P450_inhibitors dbr:Prostacyclin dbr:Enzyme_inhibitor dbr:Cytochrome_P450 dbc:Carboxylate_esters dbr:Thromboxane dbr:Endothelial_cell dbr:Enzyme dbr:Pharmacodynamics dbr:Muscarinic_acetylcholine_receptor dbr:Drug_metabolism dbr:Nitric_oxide_synthase dbc:Diethylamino_compounds dbr:Phosphatidylserine dbr:Nicotinic_acetylcholine_receptor dbr:Arachidonate dbr:Caspase-3 dbr:Glycogen_synthase_kinase_3 |
| dbp:imagefile |
Proadifen.png (en) |
| dbp:othernames |
SKF 525-A (en) |
| dbp:pin |
2 (xsd:integer) |
| dbp:title |
dbr:Pharmacodynamics |
| dbp:titlestyle |
background:#ccccff (en) |
| dbp:wikiPageUsesTemplate |
dbt:Acetylcholine_receptor_modulators dbt:Nitric_oxide_signaling_modulators dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Navboxes dbt:Reflist dbt:Fdacite dbt:Xenobiotic-sensing_receptor_modulators dbt:Sigma_receptor_modulators dbt:Ion_channel_modulators |
| dcterms:subject |
dbc:Cytochrome_P450_inhibitors dbc:Carboxylate_esters dbc:Diethylamino_compounds |
| gold:hypernym |
dbr:Inhibitor |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatCytochromeP450Inhibitors yago:Inhibitor114724436 yago:Matter100020827 yago:PhysicalEntity100001930 dbo:ChemicalCompound dbo:Drug yago:Substance100020090 |
| rdfs:comment |
Proadifen (SKF-525A) is a non-selective inhibitor of cytochrome P450 enzymes, preventing some types of drug metabolism. It is also an inhibitor of neuronal nitric oxide synthase (NOS), CYP-dependent (cytochrome P450-dependent) arachidonate metabolism, transmembrane calcium influx, and platelet thromboxane synthesis. Further documented effects include the blockade of ATP-sensitive inward rectifier potassium channel 8 (KIR6.1), and stimulation of endothelial cell prostacyclin production. (en) |
| rdfs:label |
Proadifen (en) |
| owl:sameAs |
freebase:Proadifen yago-res:Proadifen wikidata:Proadifen http://azb.dbpedia.org/resource/پروآدیفن dbpedia-fa:Proadifen dbpedia-sh:Proadifen dbpedia-sr:Proadifen https://global.dbpedia.org/id/4tbB5 |
| prov:wasDerivedFrom |
wikipedia-en:Proadifen?oldid=1086023311&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Proadifen.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Proadifen |
| is dbo:wikiPageRedirects of |
dbr:SKF-525A dbr:SKF525A dbr:SKF_525-A dbr:SKF_525A |
| is dbo:wikiPageWikiLink of |
dbr:List_of_MeSH_codes_(D02) dbr:Adinazolam dbr:C23H31NO2 dbr:SKF-525A dbr:SKF525A dbr:SKF_525-A dbr:SKF_525A |
| is foaf:primaryTopic of |
wikipedia-en:Proadifen |
