Prochloraz (original) (raw)
Prochloraz ist eine chemische Verbindung aus der Gruppe der Imidazole.
| Property | Value |
|---|---|
| dbo:abstract | Prochloraz ist eine chemische Verbindung aus der Gruppe der Imidazole. (de) Procloraz, conocido bajo la marca comercial Sportak, es un fungicida imidazol que se introdujo al mercado en 1978 y se utiliza ampliamente en Europa, Australia, Asia y América del Sur dentro de la jardinería y la agricultura para controlar el crecimiento de hongos. No está registrado para su uso en los Estados Unidos. En Argentina, se encuentra prohibido para el cultivo de cítricos. De manera similar a otros fungicidas azoles, el procloraz es un inhibidor de la enzima (CYP51A1), que es necesaria para la producción de ergosterol, un componente esencial de la membrana celular de los hongos, a partir de lanosterol. El agente es un fungicida protector y curativo de amplio espectro, eficaz contra Alternaria spp., Botrytis spp., oídio, Helminthosporium spp., Fusarium spp., Pseudocerosporella spp., Pyrenophora spp., Rhynchosporium spp. y Septoria spp. Como muchos fungicidas basados en el imidazol, triazol y antifúngicos, el procloraz no es particularmente selectivo en sus acciones. Además de la inhibición de lanosterol 14α-desmetilasa, también se ha encontrado que procloraz actúa como antagonista de los receptores de andrógenos y estrógenos, como agonista del y como inhibidor de enzimas en la vía de la esteroidogénesis como CYP17A1 y aromatasa. Se ha demostrado que produce malformaciones reproductivas en ratones. Como tal, el procloraz se considera un disruptor endocrino. (es) Le prochloraze est une molécule utilisée comme fongicide, de la famille des imidazoles. (fr) Prochloraz, brand name Sportak, is an imidazole fungicide that was introduced in 1978 and is widely used in Europe, Australia, Asia, and South America within gardening and agriculture to control the growth of fungi. It is not registered for use in the United States. Similarly to other azole fungicides, prochloraz is an inhibitor of the enzyme lanosterol 14α-demethylase (CYP51A1), which is necessary for the production of ergosterol – an essential component of the fungal cell membrane – from lanosterol. The agent is a broad-spectrum, protective and curative fungicide, effective against Alternaria spp., Botrytis spp., Erysiphe spp., Helminthosporium spp., Fusarium spp., spp., Pyrenophora spp., Rhynchosporium spp., and Septoria spp. Like many imidazole and triazole fungicides and antifungal medications, prochloraz is not particularly selective in its actions. In addition to inhibition of lanosterol 14α-demethylase, prochloraz has also been found to act as an antagonist of the androgen and estrogen receptors, as an agonist of the aryl hydrocarbon receptor, and as an inhibitor of enzymes in the steroidogenesis pathway such as CYP17A1 and aromatase. In accordance, it has been shown to produce reproductive malformations in mice. As such, prochloraz is considered to be an endocrine disruptor. (en) |
| dbo:alternativeName | Abavit, Ascurit, Dibavit, Mirage, Octave, Omega, Prelude, Rival, Sporgon, Sportak, Sprint, Tenor (en) |
| dbo:casNumber | 67747-09-5 |
| dbo:chEBI | 8434 |
| dbo:chEMBL | 522782 |
| dbo:fdaUniiCode | 99SFL01YCL |
| dbo:kegg | C11182 |
| dbo:pubchem | 73665 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Prochloraz.svg?width=300 |
| dbo:wikiPageID | 53743989 (xsd:integer) |
| dbo:wikiPageLength | 5812 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1075453311 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Procymidone dbr:Endocrine_disruptor dbr:Enzyme_inhibitor dbr:Androgen_receptor dbr:Antifungal dbr:United_States dbr:Vinclozolin dbc:Antiestrogens dbc:Aromatase_inhibitors dbc:Endocrine_disruptors dbc:Fungicides dbc:Imidazoles dbr:Erysiphe dbr:Septoria dbr:Enzyme dbr:Fungi dbr:Fusarium dbr:Botrytis_(fungus) dbr:Aromatase dbr:Fungicide dbr:Helminthosporium dbr:Receptor_antagonist dbr:Australia dbc:Nonsteroidal_antiandrogens dbr:CYP17A1 dbr:Gardening dbr:Lanosterol_14_alpha-demethylase dbr:Pyrenophora dbr:Agonist dbr:Agriculture dbc:Carboxamides dbr:Alternaria dbr:Ergosterol dbr:Estrogen_receptor dbr:Europe dbr:Cell_membrane dbr:Asia dbr:Ketoconazole dbr:Lanosterol dbr:Biosynthesis dbr:Aryl_hydrocarbon_receptor dbr:Azole dbr:Phenothrin dbr:South_America dbr:Imidazole dbr:Congenital_disorder dbr:Triazole dbr:Reproductive_system dbr:Rhynchosporium dbr:Broad-spectrum dbr:Steroidogenesis dbr:Pseudocerosporella |
| dbp:c | 15 (xsd:integer) |
| dbp:casNumber | 67747 (xsd:integer) |
| dbp:chebi | 8434 (xsd:integer) |
| dbp:chembl | 522782 (xsd:integer) |
| dbp:chemspiderid | 159925 (xsd:integer) |
| dbp:cl | 3 (xsd:integer) |
| dbp:h | 16 (xsd:integer) |
| dbp:iupacName | N-propyl-N-[2-ethyl]imidazole-1-carboxamide (en) |
| dbp:kegg | 11182.0 |
| dbp:n | 3 (xsd:integer) |
| dbp:o | 2 (xsd:integer) |
| dbp:pubchem | 73665 (xsd:integer) |
| dbp:smiles | CCCNCN2C=CN=C2 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | XJABPYGRRIVUOG-UHFFFAOYSA-N (en) |
| dbp:tradename | Abavit, Ascurit, Dibavit, Mirage, Octave, Omega, Prelude, Rival, Sporgon, Sportak, Sprint, Tenor (en) |
| dbp:unii | 99 (xsd:integer) |
| dbp:width | 200 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Androgen_receptor_modulators dbt:Drugbox dbt:Estrogen_receptor_modulators dbt:Reflist dbt:Short_description dbt:PPDB |
| dcterms:subject | dbc:Antiestrogens dbc:Aromatase_inhibitors dbc:Endocrine_disruptors dbc:Fungicides dbc:Imidazoles dbc:Nonsteroidal_antiandrogens dbc:Carboxamides |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | Prochloraz ist eine chemische Verbindung aus der Gruppe der Imidazole. (de) Le prochloraze est une molécule utilisée comme fongicide, de la famille des imidazoles. (fr) Procloraz, conocido bajo la marca comercial Sportak, es un fungicida imidazol que se introdujo al mercado en 1978 y se utiliza ampliamente en Europa, Australia, Asia y América del Sur dentro de la jardinería y la agricultura para controlar el crecimiento de hongos. No está registrado para su uso en los Estados Unidos. En Argentina, se encuentra prohibido para el cultivo de cítricos. (es) Prochloraz, brand name Sportak, is an imidazole fungicide that was introduced in 1978 and is widely used in Europe, Australia, Asia, and South America within gardening and agriculture to control the growth of fungi. It is not registered for use in the United States. Similarly to other azole fungicides, prochloraz is an inhibitor of the enzyme lanosterol 14α-demethylase (CYP51A1), which is necessary for the production of ergosterol – an essential component of the fungal cell membrane – from lanosterol. The agent is a broad-spectrum, protective and curative fungicide, effective against Alternaria spp., Botrytis spp., Erysiphe spp., Helminthosporium spp., Fusarium spp., spp., Pyrenophora spp., Rhynchosporium spp., and Septoria spp. (en) |
| rdfs:label | Prochloraz (de) Procloraz (es) Prochloraze (fr) Prochloraz (en) |
| owl:sameAs | yago-res:Prochloraz wikidata:Prochloraz dbpedia-de:Prochloraz dbpedia-es:Prochloraz dbpedia-fr:Prochloraz https://global.dbpedia.org/id/R1ba |
| prov:wasDerivedFrom | wikipedia-en:Prochloraz?oldid=1075453311&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Prochloraz.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Prochloraz |
| is dbo:wikiPageRedirects of | dbr:Ascurit dbr:Abavit dbr:Dibavit dbr:Sporgon dbr:Sportak dbr:Procloraz |
| is dbo:wikiPageWikiLink of | dbr:Procymidone dbr:List_of_compounds_with_carbon_number_15 dbr:List_of_fungicides dbr:Houayheuang_Xayabouly dbr:Zymoseptoria_tritici dbr:Ascurit dbr:Leaf_vegetable dbr:Abavit dbr:Imidazole dbr:Dibavit dbr:Wheat_diseases dbr:Steroidogenesis_inhibitor dbr:Sporgon dbr:Sportak dbr:Procloraz |
| is foaf:primaryTopic of | wikipedia-en:Prochloraz |
