Prorenone (developmental code name SC-23133) is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed. It is the lactonic form of prorenoic acid (prorenoate), and prorenoate potassium (SC-23992), the potassium salt of prorenoic acid, also exists. Prorenoate potassium is about 8 times more potent than spironolactone as an antimineralocorticoid in animals, and it may act as a prodrug to prorenone. In addition to the mineralocorticoid receptor, prorenone also binds to the glucocorticoid, androgen, and progesterone receptors. The antiandrogenic potency of prorenone in vivo in animals is close to that of spironolactone. Similarly to spironolactone, prorenone is also a potent inhibitor of aldosterone biosynthesis.
| Property |
Value |
| dbo:abstract |
Prorenone (developmental code name SC-23133) is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed. It is the lactonic form of prorenoic acid (prorenoate), and prorenoate potassium (SC-23992), the potassium salt of prorenoic acid, also exists. Prorenoate potassium is about 8 times more potent than spironolactone as an antimineralocorticoid in animals, and it may act as a prodrug to prorenone. In addition to the mineralocorticoid receptor, prorenone also binds to the glucocorticoid, androgen, and progesterone receptors. The antiandrogenic potency of prorenone in vivo in animals is close to that of spironolactone. Similarly to spironolactone, prorenone is also a potent inhibitor of aldosterone biosynthesis. (en) プロレノン(Prorenone)は、スピロノラクトン、カンレノン、に関連する合成ステロイドである。 (ja) |
| dbo:casNumber |
49848-04-6 |
| dbo:pubchem |
170819 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Prorenone.svg?width=300 |
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| dbo:wikiPageWikiLink |
dbr:Canrenone dbr:Potassium dbr:Potassium_canrenoate dbr:Potency_(pharmacology) dbr:Prorenoic_acid dbr:Enzyme_inhibitor dbr:Androgen_receptor dbr:Antimineralocorticoid dbr:Johnson–Corey–Chaykovsky_reaction dbr:In_vivo dbr:Prorenoate_potassium dbc:Antimineralocorticoids dbc:Cyclopropanes dbc:Pregnanes dbc:Progestogens dbc:Spiro_compounds dbc:Steroidal_antiandrogens dbr:Lactone dbr:Steroid dbr:Prodrug dbr:Progesterone_receptor dbc:Antiandrogens dbc:Spirolactones dbr:Aldosterone dbr:Glucocorticoid_receptor dbr:Biosynthesis dbr:Sodium_hydride dbr:Spironolactone dbr:Mexrenone dbr:Mineralocorticoid_receptor dbr:Salt_(chemistry) dbr:Spirolactone dbr:Trimethylsulfonium_iodide dbr:File:Prorenone_Synthesis.png |
| dbp:atcPrefix |
None (en) |
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23 (xsd:integer) |
| dbp:casNumber |
49848 (xsd:integer) |
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149344 (xsd:integer) |
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3 (xsd:integer) |
| dbp:pubchem |
170819 (xsd:integer) |
| dbp:smiles |
O=C6O[C@@]5CC6 (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
RRHHMFQGHCFGMH-LAPLKBAYSA-N (en) |
| dbp:synonyms |
SC-23133; 3-propionic acid γ-lactone (en) |
| dbp:wikiPageUsesTemplate |
dbt:Androgen_receptor_modulators dbt:Clear_left dbt:Drugbox dbt:Mineralocorticoid_receptor_modulators dbt:Progesterone_receptor_modulators dbt:Reflist dbt:Short_description dbt:Steroid-stub dbt:Cardiovascular-drug-stub |
| dct:subject |
dbc:Antimineralocorticoids dbc:Cyclopropanes dbc:Pregnanes dbc:Progestogens dbc:Spiro_compounds dbc:Steroidal_antiandrogens dbc:Antiandrogens dbc:Spirolactones |
| gold:hypernym |
dbr:Antimineralocorticoid |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Adversary109773245 yago:CausalAgent100007347 yago:LivingThing100004258 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:YagoLegalActor yago:YagoLegalActorGeo dbo:Drug yago:Whole100003553 yago:WikicatAldosteroneAntagonists |
| rdfs:comment |
Prorenone (developmental code name SC-23133) is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed. It is the lactonic form of prorenoic acid (prorenoate), and prorenoate potassium (SC-23992), the potassium salt of prorenoic acid, also exists. Prorenoate potassium is about 8 times more potent than spironolactone as an antimineralocorticoid in animals, and it may act as a prodrug to prorenone. In addition to the mineralocorticoid receptor, prorenone also binds to the glucocorticoid, androgen, and progesterone receptors. The antiandrogenic potency of prorenone in vivo in animals is close to that of spironolactone. Similarly to spironolactone, prorenone is also a potent inhibitor of aldosterone biosynthesis. (en) プロレノン(Prorenone)は、スピロノラクトン、カンレノン、に関連する合成ステロイドである。 (ja) |
| rdfs:label |
プロレノン (ja) Prorenone (en) |
| owl:sameAs |
freebase:Prorenone yago-res:Prorenone wikidata:Prorenone dbpedia-ja:Prorenone https://global.dbpedia.org/id/ZP4H |
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wikipedia-en:Prorenone?oldid=1087401352&ns=0 |
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wiki-commons:Special:FilePath/Prorenone.svg wiki-commons:Special:FilePath/Prorenone_Synthesis.png |
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wikipedia-en:Prorenone |
| is dbo:wikiPageWikiLink of |
dbr:Prorenoic_acid dbr:Prorenoate_potassium dbr:C23H30O3 dbr:Spironolactone dbr:Mexrenone dbr:List_of_steroidal_antiandrogens dbr:Sex_hormone-binding_globulin dbr:Spirolactone dbr:Steroidal_antiandrogen |
| is foaf:primaryTopic of |
wikipedia-en:Prorenone |
