| dbo:abstract |
Protofection is a protein-mediated transfection of foreign mitochondrial DNA (mtDNA) into the mitochondria of cells in a tissue to supplement or replace the native mitochondrial DNA already present. The complete mtDNA genome or just fragments of mtDNA generated by polymerase chain reaction can be transferred into the target mitochondria through the technique. Scientists have hypothesized for the last couple of decades that protofection can be beneficial for patients with mitochondrial diseases. This technique is a recent development and is continuously being improved. As mitochondrial DNA becomes progressively more damaged with age, this may provide a method of at least partially rejuvenating mitochondria in old tissue, restoring them to their original, youthful function. (en) |
| dbo:wikiPageExternalLink |
http://www.discoverymedicine.com/Shilpa-Iyer/2013/03/22/novel-therapeutic-approaches-for-leber-s-hereditary-optic-neuropathy/ http://www.fightaging.org/archives/2012/10/what-happened-to-protofection.php https://dx.doi.org/10.1023/B:JOBB.0000041773.20072.9e https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829286/ |
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8036048 (xsd:integer) |
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6900 (xsd:nonNegativeInteger) |
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1091555760 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Polymerase_chain_reaction dbr:Gene_therapy dbr:Mitochondrion dbr:Leber's_hereditary_optic_neuropathy dbc:Molecular_biology dbr:Cell_membrane dbr:Mitochondrial_DNA dbr:Free-radical_theory_of_aging dbr:Free_radical dbr:Transfection dbr:Protein_transduction_domain dbr:Mitochondrial_transcription_factor_A |
| dbp:wikiPageUsesTemplate |
dbt:Short_description dbt:Cell-biology-stub |
| dcterms:subject |
dbc:Molecular_biology |
| gold:hypernym |
dbr:Transfection |
| rdfs:comment |
Protofection is a protein-mediated transfection of foreign mitochondrial DNA (mtDNA) into the mitochondria of cells in a tissue to supplement or replace the native mitochondrial DNA already present. The complete mtDNA genome or just fragments of mtDNA generated by polymerase chain reaction can be transferred into the target mitochondria through the technique. (en) |
| rdfs:label |
Protofection (en) |
| owl:sameAs |
freebase:Protofection wikidata:Protofection dbpedia-th:Protofection https://global.dbpedia.org/id/4ttNm |
| prov:wasDerivedFrom |
wikipedia-en:Protofection?oldid=1091555760&ns=0 |
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wikipedia-en:Protofection |
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dbr:Mitochondrial_disease dbr:Mitochondrial_myopathy dbr:Vectors_in_gene_therapy dbr:Transfection |
| is foaf:primaryTopic of |
wikipedia-en:Protofection |