Protopine (original) (raw)
La protopina es un alcaloide bencilisoquinolínico encontrado en la amapola, en Eschscholzia californica , Fumaria officinalis, bulbos de Corydalis y especies del género Macleaya y Bocconia. Se ha descubierto que inhibe al receptor H1 de histamina. y la agregación de plaquetas. También actúa como analgésico.
| Property | Value |
|---|---|
| dbo:abstract | La protopina es un alcaloide bencilisoquinolínico encontrado en la amapola, en Eschscholzia californica , Fumaria officinalis, bulbos de Corydalis y especies del género Macleaya y Bocconia. Se ha descubierto que inhibe al receptor H1 de histamina. y la agregación de plaquetas. También actúa como analgésico. (es) Protopine is an alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. Protopine is metabolically derived from the benzylisoquinoline alkaloid (S)-Reticuline through a progressive series of five enzymatic transformations: 1) berberine bridge enzyme to (S)-Scoulerine; 2) (S)-cheilanthifoline synthase/CYP719A25 to (S)-Cheilanthifoline; 3) (S)-stylopine synthase/CYP719A20 to (S)-Stylopine; 4) (S)-tetrahydroprotoberberine N-methyltransferase to (S)-cis-N-Methylstylopine; and ultimately, 5) N-methylstylopine hydroxylase to protopine. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic. (en) プロトピン（英: protopine）は、系のアルカロイドであり、ケシ、キケマン属の塊茎、またカラクサケマン、ケナシチャンパギク、クサノオウ、タケニグサ等の他のケシ科の植物に見られる。及び血小板凝集を阻害し、鎮痛剤として作用することが知られている。ケシ科の有毒植物の乳汁に含有している有毒成分としても知られている。 (ja) La protopina è un alcaloide benzilisochinolinico presente in piante appartenenti alla famiglia delle Papaveraceae e nella Fumaria officinalis. (it) |
| dbo:iupacName | 5-Methyl-4,6,7,14-tetrahydro-2H,10H-bis([1,3]benzodioxolo)[4,5-c:5′,6′-g]azecin-13(5H)-one (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Protopine_structure.svg?width=300 |
| dbo:wikiPageID | 24437055 (xsd:integer) |
| dbo:wikiPageLength | 4795 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1064791544 (xsd:integer) |
| dbo:wikiPageWikiLink | dbc:Alkaloids_found_in_Papaveraceae dbr:Scoulerine dbr:Alkaloid dbr:Reticuline dbr:Bürgi-Dunitz_angle dbr:Protopine_6-monooxygenase dbr:(S)-cheilanthifoline_synthase dbr:(S)-stylopine_synthase dbc:Benzodioxoles dbr:Cryptopine dbr:Opium_poppy dbr:Corydalis dbr:Fumaria_officinalis dbr:Analgesic dbr:Papaveraceae dbr:Histamine_H1_receptor dbr:Chloroform dbc:Natural_opium_alkaloids dbr:BBE-like_enzymes dbr:Platelet_aggregation dbr:(S)-cheilanthifoline |
| dbp:imagefile | Protopine structure.svg (en) Protopine-from-xtal-Mercury-3D-balls.png (en) |
| dbp:pin | 5 (xsd:integer) |
| dbp:verifiedfields | changed (en) |
| dbp:verifiedrevid | 373460923 (xsd:integer) |
| dbp:watchedfields | changed (en) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Heterocyclic-stub dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Components_of_Opium |
| dcterms:subject | dbc:Alkaloids_found_in_Papaveraceae dbc:Benzodioxoles dbc:Natural_opium_alkaloids |
| gold:hypernym | dbr:Alkaloid |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatNaturalOpiumAlkaloids yago:Abstraction100002137 yago:Alkaloid114712692 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound yago:Substance100019613 yago:WikicatAlkaloids |
| rdfs:comment | La protopina es un alcaloide bencilisoquinolínico encontrado en la amapola, en Eschscholzia californica , Fumaria officinalis, bulbos de Corydalis y especies del género Macleaya y Bocconia. Se ha descubierto que inhibe al receptor H1 de histamina. y la agregación de plaquetas. También actúa como analgésico. (es) プロトピン（英: protopine）は、系のアルカロイドであり、ケシ、キケマン属の塊茎、またカラクサケマン、ケナシチャンパギク、クサノオウ、タケニグサ等の他のケシ科の植物に見られる。及び血小板凝集を阻害し、鎮痛剤として作用することが知られている。ケシ科の有毒植物の乳汁に含有している有毒成分としても知られている。 (ja) La protopina è un alcaloide benzilisochinolinico presente in piante appartenenti alla famiglia delle Papaveraceae e nella Fumaria officinalis. (it) Protopine is an alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. Protopine is metabolically derived from the benzylisoquinoline alkaloid (S)-Reticuline through a progressive series of five enzymatic transformations: 1) berberine bridge enzyme to (S)-Scoulerine; 2) (S)-cheilanthifoline synthase/CYP719A25 to (S)-Cheilanthifoline; 3) (S)-stylopine synthase/CYP719A20 to (S)-Stylopine; 4) (S)-tetrahydroprotoberberine N-methyltransferase to (S)-cis-N-Methylstylopine; and ultimately, 5) N-methylstylopine hydroxylase to protopine. (en) |
| rdfs:label | Protopina (es) Protopina (it) プロトピン (ja) Protopine (en) |
| owl:sameAs | freebase:Protopine yago-res:Protopine wikidata:Protopine http://azb.dbpedia.org/resource/پروتوپین dbpedia-es:Protopine dbpedia-fa:Protopine dbpedia-it:Protopine dbpedia-ja:Protopine dbpedia-sh:Protopine dbpedia-sr:Protopine dbpedia-th:Protopine https://global.dbpedia.org/id/3cQJH |
| prov:wasDerivedFrom | wikipedia-en:Protopine?oldid=1064791544&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Protopine_structure.svg wiki-commons:Special:FilePath/Protopine-from-xtal-Mercury-3D-balls.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Protopine |
| is dbo:wikiPageWikiLink of | dbr:Scoulerine dbr:Eomecon dbr:List_of_compounds_with_carbon_number_20 dbr:Alkaloid dbr:Argemone_albiflora dbr:Argemone_mexicana dbr:List_of_psychoactive_plants dbr:Romneya_coulteri dbr:List_of_psychoactive_plants,_fungi,_and_animals dbr:Protopine_6-monooxygenase dbr:Cryptopine dbr:Glaucium_grandiflorum dbr:Corydalis_ambigua dbr:Corydalis_filistipes dbr:Sibiricine dbr:Fumaria_officinalis dbr:Fumaria_parviflora dbr:Bürgi–Dunitz_angle dbr:Lamprocapnos dbr:Papaveraceae dbr:Chelidonium_majus dbr:Cheilanthifoline dbr:Chelidonine dbr:C20H19NO5 dbr:Poppy_tea dbr:Sanguinaria |
| is foaf:primaryTopic of | wikipedia-en:Protopine |
