Scoulerine, also known as discretamine and aequaline, is a benzylisoquinoline alkaloid (BIA) that is derived directly from (S)-reticuline through the action of berberine bridge enzyme. It is a precursor of other BIAs, notably berberine, noscapine, (S)-tetrahydropalmatine, and (S)-stylopine, as well as the alkaloids protopine, and sanguinarine. It is found in many plants, including opium poppy, , and certain plants in the genus Erythrina.
| Property |
Value |
| dbo:abstract |
Scoulerine, also known as discretamine and aequaline, is a benzylisoquinoline alkaloid (BIA) that is derived directly from (S)-reticuline through the action of berberine bridge enzyme. It is a precursor of other BIAs, notably berberine, noscapine, (S)-tetrahydropalmatine, and (S)-stylopine, as well as the alkaloids protopine, and sanguinarine. It is found in many plants, including opium poppy, , and certain plants in the genus Erythrina. Studies show that scoulerine is an antagonist in vitro at the α2-adrenoceptor, α1D-adrenoceptor and 5-HT receptor. It has also been found to be a GABAA receptor agonist in vitro. (en) |
| dbo:alternativeName |
(S)-Scoulerin; Discretamine; Aequaline (en) |
| dbo:iupacName |
(13aS)-3,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,9-diol (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Scoulerine-S.png?width=300 |
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6552196 (xsd:integer) |
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5138 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1023750338 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Protopine dbr:Sanguinarine dbr:Benzylisoquinoline dbr:Berberine dbr:Alkaloid dbr:Antagonist dbr:Reticuline dbr:In_vitro dbc:Methoxy_compounds dbc:Phenols dbr:Erythrina dbr:Opium_poppy dbc:Isoquinolinoisoquinolines dbr:GABAA_receptor dbr:5-HT_receptor dbc:Catechol_ethers dbr:Noscapine dbr:Tetrahydrocoptisine dbr:Tetrahydropalmatine dbc:Natural_opium_alkaloids dbr:BBE-like_enzymes dbr:Adrenoceptor dbr:Croton_flavens |
| dbp:imagefile |
Scoulerine-S.png (en) |
| dbp:imagename |
Scoulerine (en) |
| dbp:name |
Scoulerine (en) |
| dbp:othernames |
-Scoulerin; Discretamine; Aequaline (en) |
| dbp:pin |
-310 (xsd:integer) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
464388032 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Chembox dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Stdinchicite |
| dcterms:subject |
dbc:Methoxy_compounds dbc:Phenols dbc:Isoquinolinoisoquinolines dbc:Catechol_ethers dbc:Natural_opium_alkaloids |
| gold:hypernym |
dbr:Alkaloid |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatNaturalOpiumAlkaloids yago:Abstraction100002137 yago:Alkaloid114712692 yago:Chemical114806838 yago:Compound114818238 yago:Element114840755 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 dbo:ChemicalCompound yago:Substance100019613 yago:WikicatPhenolEthers yago:WikicatPhenols |
| rdfs:comment |
Scoulerine, also known as discretamine and aequaline, is a benzylisoquinoline alkaloid (BIA) that is derived directly from (S)-reticuline through the action of berberine bridge enzyme. It is a precursor of other BIAs, notably berberine, noscapine, (S)-tetrahydropalmatine, and (S)-stylopine, as well as the alkaloids protopine, and sanguinarine. It is found in many plants, including opium poppy, , and certain plants in the genus Erythrina. (en) |
| rdfs:label |
Scoulerine (en) |
| owl:sameAs |
freebase:Scoulerine yago-res:Scoulerine wikidata:Scoulerine http://azb.dbpedia.org/resource/اسکولرین dbpedia-fa:Scoulerine dbpedia-sh:Scoulerine dbpedia-sr:Scoulerine https://global.dbpedia.org/id/4ubaq |
| prov:wasDerivedFrom |
wikipedia-en:Scoulerine?oldid=1023750338&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Scoulerine-S.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Scoulerine |
| foaf:name |
Scoulerine (en) |
| is dbo:wikiPageRedirects of |
dbr:Aequaline dbr:Scoulerin dbr:Discretamine |
| is dbo:wikiPageWikiLink of |
dbr:Canadine dbr:Protopine dbr:Reticuline dbr:C19H21NO4 dbr:(S)-cheilanthifoline_synthase dbr:(S)-scoulerine_9-O-methyltransferase dbr:Erythrina dbr:Lamprocapnos dbr:Noscapine dbr:Aequaline dbr:BBE-like_enzymes dbr:Reticuline_oxidase dbr:Scoulerin dbr:Discretamine |
| is foaf:primaryTopic of |
wikipedia-en:Scoulerine |
