Pyridoxine 5′-phosphate oxidase (original) (raw)
Pyridoxine 5′-phosphate oxidase is an enzyme, encoded by the PNPO gene, that catalyzes several reactions in the vitamin B6 metabolism pathway. Pyridoxine 5′-phosphate oxidase catalyzes the final, rate-limiting step in vitamin B6 metabolism, the biosynthesis of pyridoxal 5′-phosphate, the biologically active form of vitamin B6 which acts as an essential cofactor. Pyridoxine 5′-phosphate oxidase is a member of the enzyme class oxidases, or more specifically, oxidoreductases. These enzymes catalyze a simultaneous oxidation-reduction reaction. The substrate oxidase enzymes is hydroxlyated by one oxygen atom of molecular oxygen.Concurrently, the other oxygen atom is reduced to water. Even though molecular oxygen is the electron acceptor in these enzymes' reactions, they are unique because oxyge
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| dbo:abstract | Pyridoxine 5′-phosphate oxidase is an enzyme, encoded by the PNPO gene, that catalyzes several reactions in the vitamin B6 metabolism pathway. Pyridoxine 5′-phosphate oxidase catalyzes the final, rate-limiting step in vitamin B6 metabolism, the biosynthesis of pyridoxal 5′-phosphate, the biologically active form of vitamin B6 which acts as an essential cofactor. Pyridoxine 5′-phosphate oxidase is a member of the enzyme class oxidases, or more specifically, oxidoreductases. These enzymes catalyze a simultaneous oxidation-reduction reaction. The substrate oxidase enzymes is hydroxlyated by one oxygen atom of molecular oxygen.Concurrently, the other oxygen atom is reduced to water. Even though molecular oxygen is the electron acceptor in these enzymes' reactions, they are unique because oxygen does not appear in the oxidized product. The active form of vitamin B6, pyridoxal 5'-phosphate (PLP), is critical for normal cellular function. Some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. The rate-limiting enzyme in vitamin B6 synthesis is pyridoxine-5'-phosphate oxidase (PNPO; EC 1.4.3.5).[supplied by OMIM] (en) La piridossale 5'-fosfato sintasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: piridossamina 5′-fosfato + H2O + O2 ⇄ piridossale 5′-fosfato + NH3 + H2O2piridossina 5′-fosfato + O2 ⇄ piridossale 5′-fosfato+ H2O2 L'enzima è una flavoproteina contenente FMN. In Escherichia coli il coenzima piridossale 5′-fosfato è sintetizzato de novo da un pathway che coinvolge la , la , la , la 4-idrossitreonina-4-fosfato deidrogenasi, la e la piridossale 5'-fosfato sintasi (con piridossina 5′-fosfato come substrato). Anche i derivati della piridossamina sostituiti presso N4′ sono ossidati nella reazione, a formare piridossale 5′-fosfato e la corrispondente ammina primaria. (it) ピリドキサール-5'-リン酸シンターゼ(pyridoxal 5'-phosphate synthase)は、次の化学反応を触媒する酸化還元酵素である。 (1) ピリドキサミン-5'-リン酸 + H2O + O2 ピリドキサール-5'-リン酸 + NH3 + H2O2 反応式の通り、基質はとH2OとO2、生成物はピリドキサール-5'-リン酸とNH3とH2O2である。 (2) ピリドキシン-5'-リン酸 + O2 ピリドキサール-5'-リン酸 + H2O2 反応式の通り、基質はとO2、生成物はピリドキサール-5'-リン酸とH2O2である。 組織名はpyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)で、別名にpyridoxamine 5'-phosphate oxidase, pyridoxamine phosphate oxidase, pyridoxine (pyridoxamine)phosphate oxidase, pyridoxine (pyridoxamine) 5'-phosphate oxidase, pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating), PMP oxidase, pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating) (incorrect), pyridoxamine-phosphate oxidase, PdxHがある。 (ja) |
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| dct:subject | dbc:EC_1.4.3 |
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| rdfs:comment | Pyridoxine 5′-phosphate oxidase is an enzyme, encoded by the PNPO gene, that catalyzes several reactions in the vitamin B6 metabolism pathway. Pyridoxine 5′-phosphate oxidase catalyzes the final, rate-limiting step in vitamin B6 metabolism, the biosynthesis of pyridoxal 5′-phosphate, the biologically active form of vitamin B6 which acts as an essential cofactor. Pyridoxine 5′-phosphate oxidase is a member of the enzyme class oxidases, or more specifically, oxidoreductases. These enzymes catalyze a simultaneous oxidation-reduction reaction. The substrate oxidase enzymes is hydroxlyated by one oxygen atom of molecular oxygen.Concurrently, the other oxygen atom is reduced to water. Even though molecular oxygen is the electron acceptor in these enzymes' reactions, they are unique because oxyge (en) ピリドキサール-5'-リン酸シンターゼ(pyridoxal 5'-phosphate synthase)は、次の化学反応を触媒する酸化還元酵素である。 (1) ピリドキサミン-5'-リン酸 + H2O + O2 ピリドキサール-5'-リン酸 + NH3 + H2O2 反応式の通り、基質はとH2OとO2、生成物はピリドキサール-5'-リン酸とNH3とH2O2である。 (2) ピリドキシン-5'-リン酸 + O2 ピリドキサール-5'-リン酸 + H2O2 反応式の通り、基質はとO2、生成物はピリドキサール-5'-リン酸とH2O2である。 (ja) La piridossale 5'-fosfato sintasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: piridossamina 5′-fosfato + H2O + O2 ⇄ piridossale 5′-fosfato + NH3 + H2O2piridossina 5′-fosfato + O2 ⇄ piridossale 5′-fosfato+ H2O2 (it) |
| rdfs:label | Piridossale 5'-fosfato sintasi (it) ピリドキサール-5'-リン酸シンターゼ (ja) Pyridoxine 5′-phosphate oxidase (en) |
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| foaf:name | Pyridoxal 5′-phosphate synthase (en) |
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