| dbo:abstract |
QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more selective than most other drugs of this class and so produces somewhat less sedation and ataxia than other related drugs such as diazepam and triazolam, although it still retains anticonvulsant effects. QH-ii-066 is a highly subtype-selective GABAA agonist which was designed to bind selectively to the α5 subtype of GABAA receptors. The α5 subtype (and to a lesser extent the α1 subtype) of GABAA are two of the most important targets in the brain that produce the effects of alcohol, and so one of the purposes for which QH-ii-066 was developed was to reproduce the GABAergic effects of alcohol separately from its other actions. QH-ii-066 replicates some of the effects of alcohol, such as sedation and ataxia, but does not increase appetite, as this effect seems to be produced by the α1 subtype of GABAA rather than α5. The inverse agonist Ro15-4513, which blocks the α5 subtype of GABAA, reverses the effects of alcohol, suggesting that this subtype is also important in producing the subjective effects of alcohol intoxication. (en) Il QH-II-66 è un sedativo appartenente alla categoria delle benzodiazepine. Produce alcuni degli stessi effetti delle altre benzodiazepine, ma è più selettivo della maggior parte degli altri farmaci di questa classe e quindi produce meno sedazione e atassia rispetto ad altri farmaci correlati come diazepam e triazolam, sebbene mantenga effetti anticonvulsivanti. (it) |
| dbo:casNumber |
183239-39-6 |
| dbo:chEMBL |
174535 |
| dbo:fdaUniiCode |
PKW6UCK55B |
| dbo:pubchem |
9838431 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/QH-II-66.svg?width=300 |
| dbo:wikiPageID |
13353724 (xsd:integer) |
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6291 (xsd:nonNegativeInteger) |
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| dbo:wikiPageWikiLink |
dbr:Benzodiazepine dbr:Anticonvulsant dbr:Ro15-4513 dbc:Ethynyl_compounds dbc:GABAA_receptor_positive_allosteric_modulators dbc:Hypnotics dbc:Lactams dbc:Sedatives dbr:SH-I-048A dbr:SH-053-R-CH3-2′F dbr:Gamma-aminobutyric_acid dbr:Triazolam dbr:GABAA_receptor dbr:GABRA5 dbr:GL-II-73 dbr:Agonist dbc:Benzodiazepines dbr:Ataxia dbr:Inverse_agonist dbr:Alcoholic_beverage dbr:Diazepam dbr:Sedative |
| dbp:c |
18 (xsd:integer) |
| dbp:casNumber |
183239 (xsd:integer) |
| dbp:chembl |
174535 (xsd:integer) |
| dbp:chemspiderid |
8014151 (xsd:integer) |
| dbp:h |
14 (xsd:integer) |
| dbp:image |
Qhii663d.png (en) |
| dbp:iupacName |
7 (xsd:integer) |
| dbp:legalCa |
Schedule IV (en) |
| dbp:legalDe |
NpSG (en) |
| dbp:legalUk |
PSA (en) |
| dbp:molecularWeight |
274.330000 (xsd:double) |
| dbp:n |
2 (xsd:integer) |
| dbp:o |
1 (xsd:integer) |
| dbp:pubchem |
9838431 (xsd:integer) |
| dbp:smiles |
O=C1NC2=CC=CC#C (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
FESCSZDQOFYRDR-UHFFFAOYSA-N (en) |
| dbp:unii |
PKW6UCK55B (en) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
464378091 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:width |
200 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Hypnotics_and_sedatives dbt:Drugbox dbt:GABAAR_PAMs dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Benzodiazepines dbt:Sedative-stub |
| dcterms:subject |
dbc:Ethynyl_compounds dbc:GABAA_receptor_positive_allosteric_modulators dbc:Hypnotics dbc:Lactams dbc:Sedatives dbc:Benzodiazepines |
| gold:hypernym |
dbr:Drug |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatBenzodiazepines yago:WikicatSedatives yago:Agent114778436 yago:Benzodiazepine102830852 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Hypnagogue114913744 yago:Matter100020827 yago:Medicine103740161 yago:MinorTranquilizer103771443 yago:MuscleRelaxant103800001 yago:PhysicalEntity100001930 yago:PsychotropicAgent104017429 yago:Relaxant104072811 yago:WikicatHypnotics dbo:Drug yago:Sedative-hypnotic104166841 yago:Sedative104166553 yago:Soporific104260934 yago:Substance100020090 yago:Tranquilizer104470232 |
| rdfs:comment |
Il QH-II-66 è un sedativo appartenente alla categoria delle benzodiazepine. Produce alcuni degli stessi effetti delle altre benzodiazepine, ma è più selettivo della maggior parte degli altri farmaci di questa classe e quindi produce meno sedazione e atassia rispetto ad altri farmaci correlati come diazepam e triazolam, sebbene mantenga effetti anticonvulsivanti. (it) QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more selective than most other drugs of this class and so produces somewhat less sedation and ataxia than other related drugs such as diazepam and triazolam, although it still retains anticonvulsant effects. QH-ii-066 is a highly subtype-selective GABAA agonist which was designed to bind selectively to the α5 subtype of GABAA receptors. (en) |
| rdfs:label |
QH-II-66 (it) QH-II-66 (en) |
| owl:sameAs |
freebase:QH-II-66 yago-res:QH-II-66 wikidata:QH-II-66 dbpedia-it:QH-II-66 dbpedia-sh:QH-II-66 dbpedia-sr:QH-II-66 https://global.dbpedia.org/id/4u7Lu |
| prov:wasDerivedFrom |
wikipedia-en:QH-II-66?oldid=1123033643&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/QH-II-66.svg wiki-commons:Special:FilePath/Qhii663d.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:QH-II-66 |
| is dbo:wikiPageRedirects of |
dbr:QH-ii-066 |
| is dbo:wikiPageWikiLink of |
dbr:SH-I-048A dbr:GABAA_receptor dbr:GL-II-73 dbr:QH-ii-066 |
| is foaf:primaryTopic of |
wikipedia-en:QH-II-66 |
