SCO1 (original) (raw)
Protein SCO1 homolog, mitochondrial, also known as SCO1, cytochrome c oxidase assembly protein, is a protein that in humans is encoded by the SCO1 gene. SCO1 localizes predominantly to blood vessels, whereas SCO2 is barely detectable, as well as to tissues with high levels of oxidative phosphorylation. The expression of SCO2 is also much higher than that of SCO1 in muscle tissue, while SCO1 is expressed at higher levels in liver tissue than SCO2. Mutations in both SCO1 and SCO2 are associated with distinct clinical phenotypes as well as tissue-specific cytochrome c oxidase (complex IV) deficiency.
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| dbo:abstract | Protein SCO1 homolog, mitochondrial, also known as SCO1, cytochrome c oxidase assembly protein, is a protein that in humans is encoded by the SCO1 gene. SCO1 localizes predominantly to blood vessels, whereas SCO2 is barely detectable, as well as to tissues with high levels of oxidative phosphorylation. The expression of SCO2 is also much higher than that of SCO1 in muscle tissue, while SCO1 is expressed at higher levels in liver tissue than SCO2. Mutations in both SCO1 and SCO2 are associated with distinct clinical phenotypes as well as tissue-specific cytochrome c oxidase (complex IV) deficiency. (en) SCO1 (англ. SCO1, cytochrome c oxidase assembly protein) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 301 амінокислот, а молекулярна маса — 33 814. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до шаперонів. Білок має сайт для зв'язування з іоном міді, іонами металів. Локалізований у мітохондрії. (uk) |
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| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 yago:Abstraction100002137 yago:Arrangement107938773 yago:Gene105436752 yago:Group100031264 yago:Ordering108456993 yago:WikicatGenesMutatedInMice dbo:HumanGene dbo:Protein yago:Sequence108459252 yago:Series108457976 |
| rdfs:comment | Protein SCO1 homolog, mitochondrial, also known as SCO1, cytochrome c oxidase assembly protein, is a protein that in humans is encoded by the SCO1 gene. SCO1 localizes predominantly to blood vessels, whereas SCO2 is barely detectable, as well as to tissues with high levels of oxidative phosphorylation. The expression of SCO2 is also much higher than that of SCO1 in muscle tissue, while SCO1 is expressed at higher levels in liver tissue than SCO2. Mutations in both SCO1 and SCO2 are associated with distinct clinical phenotypes as well as tissue-specific cytochrome c oxidase (complex IV) deficiency. (en) SCO1 (англ. SCO1, cytochrome c oxidase assembly protein) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 301 амінокислот, а молекулярна маса — 33 814. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | SCO1 (en) SCO1 (uk) |
| owl:sameAs | freebase:SCO1 yago-res:SCO1 wikidata:SCO1 dbpedia-cy:SCO1 http://tt.dbpedia.org/resource/SCO1 dbpedia-uk:SCO1 https://global.dbpedia.org/id/jgEy |
| prov:wasDerivedFrom | wikipedia-en:SCO1?oldid=1109694618&ns=0 |
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| is dbo:wikiPageWikiLink of | dbr:List_of_human_protein-coding_genes_3 dbr:Calcium-binding_mitochondrial_carrier_protein_Aralar1 dbr:SCO2 dbr:Cytochrome_c_oxidase dbr:COX20 dbr:COA6 dbr:SCO1_(gene) dbr:Sco1 |
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