STS-135 (drug) (original) (raw)
STS-135 (N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA) is a designer drug offered by online vendors as a cannabimimetic agent. The structure of STS-135 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. STS-135 is the terminally-fluorinated analogue of SDB-001, just as AM-2201 is the terminally-fluorinated analogue of JWH-018, and XLR-11 is the terminally-fluorinated analogue of UR-144. STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors, and 13 nM for human CB1 receptors. STS-135 produces bradycardia and hypothermia in rats at doses of 1–10 mg/kg, suggesting cannabinoid-like activity.
| Property | Value |
|---|---|
| dbo:abstract | STS-135 (N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA) is a designer drug offered by online vendors as a cannabimimetic agent. The structure of STS-135 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. STS-135 is the terminally-fluorinated analogue of SDB-001, just as AM-2201 is the terminally-fluorinated analogue of JWH-018, and XLR-11 is the terminally-fluorinated analogue of UR-144. STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors, and 13 nM for human CB1 receptors. STS-135 produces bradycardia and hypothermia in rats at doses of 1–10 mg/kg, suggesting cannabinoid-like activity. (en) |
| dbo:casNumber | 1354631-26-7 |
| dbo:fdaUniiCode | E6917946XH |
| dbo:pubchem | 57404059 |
| dbo:thumbnail | wiki-commons:Special:FilePath/5F-APICA.svg?width=300 |
| dbo:wikiPageID | 37694308 (xsd:integer) |
| dbo:wikiPageLength | 4226 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1086238112 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Bradycardia dbr:Designer_drug dbr:EC50 dbr:XLR-11_(drug) dbc:Adamantanes dbc:Cannabinoids dbc:Designer_drugs dbc:Indoles dbc:Organofluorides dbc:Indolecarboxamides dbr:UR-144 dbr:AB-001 dbr:AM-2201 dbr:APICA_(synthetic_cannabinoid_drug) dbr:APINACA dbr:ADAMANTYL-THPINACA dbr:JWH-018 dbr:SDB-001 dbr:Structure-activity_relationship |
| dbp:c | 24 (xsd:integer) |
| dbp:casNumber | 1354631 (xsd:integer) |
| dbp:chemspiderid | 28189067 (xsd:integer) |
| dbp:drugName | STS-135 (en) |
| dbp:f | 1 (xsd:integer) |
| dbp:h | 31 (xsd:integer) |
| dbp:iupacName | N--1--1H-indole-3-carboxamide (en) |
| dbp:legalCa | Schedule II (en) |
| dbp:legalDe | Anlage II (en) |
| dbp:legalNz | Temporary class (en) |
| dbp:legalUk | Class B (en) |
| dbp:n | 2 (xsd:integer) |
| dbp:o | 1 (xsd:integer) |
| dbp:pubchem | 57404059 (xsd:integer) |
| dbp:smiles | FCCCCCn1ccCNC12CC3CCCCC3 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | COYHGVCHRRXECF-UHFFFAOYSA-N (en) |
| dbp:unii | E6917946XH (en) |
| dbp:width | 200 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:About dbt:Cannabinoid-stub dbt:Cannabinoids dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Fdacite |
| dct:subject | dbc:Adamantanes dbc:Cannabinoids dbc:Designer_drugs dbc:Indoles dbc:Organofluorides dbc:Indolecarboxamides |
| gold:hypernym | dbr:Drug |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Communication100033020 yago:Formula106816935 yago:Message106598915 yago:MolecularFormula106817173 dbo:Drug yago:Statement106722453 |
| rdfs:comment | STS-135 (N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA) is a designer drug offered by online vendors as a cannabimimetic agent. The structure of STS-135 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. STS-135 is the terminally-fluorinated analogue of SDB-001, just as AM-2201 is the terminally-fluorinated analogue of JWH-018, and XLR-11 is the terminally-fluorinated analogue of UR-144. STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors, and 13 nM for human CB1 receptors. STS-135 produces bradycardia and hypothermia in rats at doses of 1–10 mg/kg, suggesting cannabinoid-like activity. (en) |
| rdfs:label | STS-135 (drug) (en) |
| owl:sameAs | freebase:STS-135 (drug) yago-res:STS-135 (drug) wikidata:STS-135 (drug) https://global.dbpedia.org/id/4uePB |
| prov:wasDerivedFrom | wikipedia-en:STS-135_(drug)?oldid=1086238112&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/5F-APICA.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:STS-135_(drug) |
| foaf:name | STS-135 (en) |
| is dbo:wikiPageRedirects of | dbr:C24H31FN2O dbr:5F-APICA |
| is dbo:wikiPageWikiLink of | dbr:List_of_designer_drugs dbr:Liebermann_reagent dbr:List_of_miscellaneous_designer_cannabinoids dbr:List_of_psychedelic_drugs dbr:Synthetic_cannabinoids dbr:SDB-006 dbr:5F-AMB dbr:5F-SDB-006 dbr:C24H31FN2O dbr:Drugs_controlled_by_the_German_Betäubungsmittelgesetz dbr:5F-ADBICA dbr:ADB-FUBINACA dbr:ADBICA dbr:APICA_(synthetic_cannabinoid_drug) dbr:APINACA dbr:Adamantyl-THPINACA dbr:FAB-144 dbr:FUB-144 dbr:PB-22 dbr:XLR-11 dbr:5F-APICA dbr:Temporary_class_drug |
| is foaf:primaryTopic of | wikipedia-en:STS-135_(drug) |
