XLR-11 (original) (raw)
XLR-11 (5"-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively. It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-796,260 and A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other similar compounds, and appears to have not previously been made by Abbott Laboratories, despite falling within the claims of patent WO 2006/069196. XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3 mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135.
| Property | Value |
|---|---|
| dbo:abstract | XLR-11 (5"-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively. It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-796,260 and A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other similar compounds, and appears to have not previously been made by Abbott Laboratories, despite falling within the claims of patent WO 2006/069196. XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3 mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135. (en) |
| dbo:casNumber | 1364933-54-9 |
| dbo:fdaUniiCode | L2M8B977ZE |
| dbo:pubchem | 57501498 |
| dbo:thumbnail | wiki-commons:Special:FilePath/XLR-11_structure.png?width=300 |
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| dbo:wikiPageLength | 9125 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1082420582 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Cannabinoid_receptor dbc:Cannabinoids dbc:Cyclopropanes dbc:Designer_drugs dbc:Indoles dbc:Organofluorides dbr:STS-135_(drug) dbr:Synthetic_cannabis dbc:Tetramethylcyclopropanoylindoles dbr:Acute_kidney_injury dbr:UR-144 dbr:A-796,260 dbr:A-834,735 dbr:AM-2201 dbr:APICA_(synthetic_cannabinoid_drug) dbr:Abbott_Laboratories dbr:Agonist dbr:FAB-144 dbr:JWH-018 dbr:Cannabinoid_receptor_type_1 dbr:Cannabinoid_receptor_type_2 dbr:XLR-12 dbr:Temporary_class_drug |
| dbp:c | 21 (xsd:integer) |
| dbp:casNumber | 1364933 (xsd:integer) |
| dbp:chemspiderid | 28537382 (xsd:integer) |
| dbp:f | 1 (xsd:integer) |
| dbp:h | 28 (xsd:integer) |
| dbp:iupacName | methanone (en) |
| dbp:legalCa | Schedule II (en) |
| dbp:legalDe | Anlage II (en) |
| dbp:legalNz | Temporary Class (en) |
| dbp:legalUk | Class B (en) |
| dbp:legalUs | Schedule I (en) |
| dbp:n | 1 (xsd:integer) |
| dbp:o | 1 (xsd:integer) |
| dbp:pubchem | 57501498 (xsd:integer) |
| dbp:smiles | CC1C (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | PXLDPUUMIHVLEC-UHFFFAOYSA-N (en) |
| dbp:unii | L2M8B977ZE (en) |
| dbp:wikiPageUsesTemplate | dbt:About dbt:Cannabinoids dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Use_dmy_dates dbt:Cascite |
| dct:subject | dbc:Cannabinoids dbc:Cyclopropanes dbc:Designer_drugs dbc:Indoles dbc:Organofluorides dbc:Tetramethylcyclopropanoylindoles |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | XLR-11 (5"-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively. It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-796,260 and A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other similar compounds, and appears to have not previously been made by Abbott Laboratories, despite falling within the claims of patent WO 2006/069196. XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3 mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135. (en) |
| rdfs:label | XLR-11 (en) |
| owl:sameAs | wikidata:XLR-11 dbpedia-sh:XLR-11 dbpedia-sr:XLR-11 https://global.dbpedia.org/id/4xZF2 |
| prov:wasDerivedFrom | wikipedia-en:XLR-11?oldid=1082420582&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/XLR-11_structure.png |
| foaf:isPrimaryTopicOf | wikipedia-en:XLR-11 |
| is dbo:wikiPageRedirects of | dbr:XLR-11_(drug) dbr:C21H28FNO dbr:FUR-144 dbr:5F-UR-144 |
| is dbo:wikiPageWikiLink of | dbr:List_of_miscellaneous_designer_cannabinoids dbr:Synthetic_cannabinoids dbr:XLR-11_(drug) dbr:MDA-19 dbr:5F-SDB-006 dbr:C21H28FNO dbr:PB-22 dbr:FUR-144 dbr:5F-UR-144 |
| is foaf:primaryTopic of | wikipedia-en:XLR-11 |
