Sandalore (original) (raw)
Sandalore is a synthetic sandalwood odorant with odor in some ways similar to sandalwood and consequently used in perfumes, emollients, and skin cleaning agents. Sandalore, and the similar , have been identified as agonists of the cutaneous olfactory receptor , and found to induce strong Ca2+ signals in cultured human keratinocytes. The long-term stimulation of keratinocytes with Sandalore positively affected cell proliferation and migration, and regeneration of keratinocyte monolayers in an in vitro wound scratch assay (i.e., sandalore stimulation also enhanced epidermal "wound healing" in human skin organ cultures). Natural sandalwood oil and other synthetic sandalwood odorants did not have the same effect.
| Property | Value |
|---|---|
| dbo:abstract | Sandalor je organická sloučenina patřící mezi alkoholy. Voní podobně jako santalové dřevo, i když se v něm samotném nevyskytuje. Využívá se v parfémech, změkčovadlech a prostředcích na čištění kůže. Sandalor funguje jako agonista kožního čichového receptoru OR2AT4. Při dlouhodobém působení příznivě ovlivňuje množení a migraci buněk, a urychluje tudíž hojení ran. Receptor OR2AT4 nacházíme také v nejsvrchnější vrstvě vlasových cibulek. Působení sandaloru stimuluje růst vlasů snižováním kontrolované buněčné smrti (apoptózy) a zvyšováním produkce příslušného růstového faktoru. Přírodní olej ze santalového dřeva tento účinek nemá. (cs) Sandalore is a synthetic sandalwood odorant with odor in some ways similar to sandalwood and consequently used in perfumes, emollients, and skin cleaning agents. Sandalore, and the similar , have been identified as agonists of the cutaneous olfactory receptor , and found to induce strong Ca2+ signals in cultured human keratinocytes. The long-term stimulation of keratinocytes with Sandalore positively affected cell proliferation and migration, and regeneration of keratinocyte monolayers in an in vitro wound scratch assay (i.e., sandalore stimulation also enhanced epidermal "wound healing" in human skin organ cultures). Natural sandalwood oil and other synthetic sandalwood odorants did not have the same effect. (en) |
| dbo:alternativeName | Sandal pentanol (en) |
| dbo:iupacName | 3-Methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/sandalore.svg?width=300 |
| dbo:wikiPageID | 47374753 (xsd:integer) |
| dbo:wikiPageLength | 2635 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1000602778 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:In_vitro dbc:Secondary_alcohols dbr:Keratinocyte dbr:Agonist dbc:Perfume_ingredients dbr:Odorant dbr:Sandalwood dbr:Sandalwood_oil dbr:Olfactory_receptor dbr:Brahmanol dbr:OR2AT4 |
| dbp:imagefile | sandalore.svg (en) |
| dbp:imagesize | 200 (xsd:integer) |
| dbp:othernames | Sandal pentanol (en) |
| dbp:pin | 3 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:GHS07 dbt:GHS09 dbt:H-phrases dbt:P-phrases |
| dcterms:subject | dbc:Secondary_alcohols dbc:Perfume_ingredients |
| gold:hypernym | dbr:Odorant |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | Sandalore is a synthetic sandalwood odorant with odor in some ways similar to sandalwood and consequently used in perfumes, emollients, and skin cleaning agents. Sandalore, and the similar , have been identified as agonists of the cutaneous olfactory receptor , and found to induce strong Ca2+ signals in cultured human keratinocytes. The long-term stimulation of keratinocytes with Sandalore positively affected cell proliferation and migration, and regeneration of keratinocyte monolayers in an in vitro wound scratch assay (i.e., sandalore stimulation also enhanced epidermal "wound healing" in human skin organ cultures). Natural sandalwood oil and other synthetic sandalwood odorants did not have the same effect. (en) Sandalor je organická sloučenina patřící mezi alkoholy. Voní podobně jako santalové dřevo, i když se v něm samotném nevyskytuje. Využívá se v parfémech, změkčovadlech a prostředcích na čištění kůže. Sandalor funguje jako agonista kožního čichového receptoru OR2AT4. Při dlouhodobém působení příznivě ovlivňuje množení a migraci buněk, a urychluje tudíž hojení ran. (cs) |
| rdfs:label | Sandalor (cs) Sandalore (en) |
| owl:sameAs | wikidata:Sandalore dbpedia-cs:Sandalore https://global.dbpedia.org/id/zYZk yago-res:Sandalore |
| prov:wasDerivedFrom | wikipedia-en:Sandalore?oldid=1000602778&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/sandalore.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Sandalore |
| is dbo:wikiPageRedirects of | dbr:C14H26O |
| is dbo:wikiPageWikiLink of | dbr:C14H26O dbr:Sandalwood dbr:Sandalwood_oil |
| is foaf:primaryTopic of | wikipedia-en:Sandalore |
