Seipin (original) (raw)
Seipin is a homo-oligomeric integral membrane protein in the endoplasmic reticulum (ER) that concentrates at junctions with cytoplasmic lipid droplets (LDs). Alternatively, seipin can be referred to as Bernardinelli-Seip congenital lipodystrophy type 2 protein (BSCL2), and it is encoded by the corresponding gene of the same name, i.e. BSCL2. At protein level, seipin is expressed in cortical neurons in the frontal lobes, as well as motor neurons in the spinal cord. It is highly expressed in areas like the brain, testis and adipose tissue. Seipin's function is still unclear but it has been localized close to lipid droplets, and cells knocked out in seipin which have anomalous droplets. Hence, recent evidence suggests that seipin plays a crucial role in lipid droplet biogenesis.
| Property | Value |
|---|---|
| dbo:abstract | La seipina es una proteína de membrana del retículo endoplasmático codificada por el gen BSCL2 del cromosoma 11 humano, está formada por una cadena de 398 aminoácidos. Las mutaciones del gen BSCL2 dan lugar a una proteína seipina anómala, lo cual puede originar varias enfermedades diferentes dependiendo de la mutación concreta, son conocidas genéricamente como seipinopatías, una de ellas es la lipodistrofia congénita de Berardinelli-Seip. La seipina se expresa sobre todo en las neuronas de los lóbulos frontales de la corteza cerebral y en las motoneuronas de la médula espinal, en menor grado en tésticulos y tejido adiposo. La función que desempeña la seipina en el organismo no está totalmente aclarada, actúa como reguladora en el catabolismo de los lípidos y es esencial para la diferenciación de los adipocitos. (es) Seipin is a homo-oligomeric integral membrane protein in the endoplasmic reticulum (ER) that concentrates at junctions with cytoplasmic lipid droplets (LDs). Alternatively, seipin can be referred to as Bernardinelli-Seip congenital lipodystrophy type 2 protein (BSCL2), and it is encoded by the corresponding gene of the same name, i.e. BSCL2. At protein level, seipin is expressed in cortical neurons in the frontal lobes, as well as motor neurons in the spinal cord. It is highly expressed in areas like the brain, testis and adipose tissue. Seipin's function is still unclear but it has been localized close to lipid droplets, and cells knocked out in seipin which have anomalous droplets. Hence, recent evidence suggests that seipin plays a crucial role in lipid droplet biogenesis. (en) |
| dbo:symbol | Seipin |
| dbo:thumbnail | wiki-commons:Special:FilePath/SEIPINS.jpg?width=300 |
| dbo:wikiPageExternalLink | https://www.uniprot.org/uniprot/Q96G97 https://www.youtube.com/watch%3Fv=W-Pdl2L20IM |
| dbo:wikiPageID | 48370875 (xsd:integer) |
| dbo:wikiPageLength | 16430 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1090295769 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:BSCL2 dbr:Encephalopathy dbr:Endoplasmic_reticulum dbr:Monounsaturated_fat dbr:Primary_transcript dbr:Hypertrophic_cardiomyopathy dbr:Cytoplasm dbr:Cardiac_muscle_cell dbr:Dyslipidemia dbr:Integral_membrane_protein dbr:Upper_motor_neuron_lesion dbr:Saturated_fat dbr:Congenital_generalized_lipodystrophy dbr:Ester dbr:Vacuole dbr:Phosphatidic_acid dbr:Motor_neuron_disease dbr:Spermatid dbr:Phospholipid dbc:Membrane_proteins dbr:Adipocyte dbr:Distal_hereditary_motor_neuronopathies dbr:Fatty_liver dbr:Lipid_droplet dbr:Amino_acid dbc:Biochemistry dbr:Chromosome_11 dbr:Germ_cell dbr:Endoplasmic_Reticulum_Stress_in_Beta_Cells dbr:Hereditary_spastic_paraplegia dbr:Asparagine dbr:Ectopia_(medicine) dbr:Muscle_weakness dbr:Autophagy dbr:Phosphoric_acid dbr:Phosphoserine dbr:Insulin dbr:Serine dbr:Exon dbr:Subcellular_localization dbr:Transmembrane_domain dbr:N-terminus dbr:Silver–Russell_syndrome dbr:Polyunsaturated_fat dbr:Nuclear_membrane dbr:Teratospermia dbr:Spermiogenesis dbr:File:SEIPINS.jpg |
| dbp:interpro | IPR009617 (en) |
| dbp:name | Putative adipose-regulatory protein (en) |
| dbp:opmFamily | 526 (xsd:integer) |
| dbp:opmProtein | 6 (xsd:integer) |
| dbp:pfam | PF06775 (en) |
| dbp:symbol | Seipin (en) |
| dbp:wikiPageUsesTemplate | dbt:Reflist dbt:Short_description dbt:Pfam_box |
| dcterms:subject | dbc:Membrane_proteins dbc:Biochemistry |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 dbo:Protein |
| rdfs:comment | Seipin is a homo-oligomeric integral membrane protein in the endoplasmic reticulum (ER) that concentrates at junctions with cytoplasmic lipid droplets (LDs). Alternatively, seipin can be referred to as Bernardinelli-Seip congenital lipodystrophy type 2 protein (BSCL2), and it is encoded by the corresponding gene of the same name, i.e. BSCL2. At protein level, seipin is expressed in cortical neurons in the frontal lobes, as well as motor neurons in the spinal cord. It is highly expressed in areas like the brain, testis and adipose tissue. Seipin's function is still unclear but it has been localized close to lipid droplets, and cells knocked out in seipin which have anomalous droplets. Hence, recent evidence suggests that seipin plays a crucial role in lipid droplet biogenesis. (en) La seipina es una proteína de membrana del retículo endoplasmático codificada por el gen BSCL2 del cromosoma 11 humano, está formada por una cadena de 398 aminoácidos. Las mutaciones del gen BSCL2 dan lugar a una proteína seipina anómala, lo cual puede originar varias enfermedades diferentes dependiendo de la mutación concreta, son conocidas genéricamente como seipinopatías, una de ellas es la lipodistrofia congénita de Berardinelli-Seip. La seipina se expresa sobre todo en las neuronas de los lóbulos frontales de la corteza cerebral y en las motoneuronas de la médula espinal, en menor grado en tésticulos y tejido adiposo. La función que desempeña la seipina en el organismo no está totalmente aclarada, actúa como reguladora en el catabolismo de los lípidos y es esencial para la diferencia (es) |
| rdfs:label | Seipina (es) Seipin (en) |
| owl:sameAs | yago-res:Seipin wikidata:Seipin dbpedia-es:Seipin https://global.dbpedia.org/id/26DZy |
| prov:wasDerivedFrom | wikipedia-en:Seipin?oldid=1090295769&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/SEIPINS.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Seipin |
| is dbo:wikiPageWikiLink of | dbr:BSCL2 dbr:Integral_membrane_protein dbr:Proteinopathy dbr:Congenital_generalized_lipodystrophy dbr:Lipid_droplet |
| is foaf:primaryTopic of | wikipedia-en:Seipin |
