Serum iron (original) (raw)
La sidérémie ou fer sérique est le taux de fer en circulation dans le plasma sanguin (55% du volume du sang en moyenne), lié à la transferrine. Le fer sérique n'inclut donc pas le fer fixé à l’hémoglobine à l'intérieur des globules rouges. Le taux normal chez l'adulte moyen est compris entre 0,6 et 1,9 mg/L, soit entre 11 et 34 micromoles/L .
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| dbo:abstract | Serum iron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin (90%) and serum ferritin (10%). Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems. 65% of the iron in the body is bound up in hemoglobin molecules in red blood cells. About 4% is bound up in myoglobin molecules. Around 30% of the iron in the body is stored as ferritin or hemosiderin in the spleen, the bone marrow and the liver. Small amounts of iron can be found in other molecules in cells throughout the body. None of this iron is directly accessible by testing the serum.} However, some iron is circulating in the serum. Transferrin is a molecule produced by the liver that binds one or two iron(III) ions, i.e. ferric iron, Fe3+; transferrin is essential if stored iron is to be moved and used. Most of the time, about 30% of the available sites on the transferrin molecule are filled. The test for serum iron uses blood drawn from veins to measure the iron ions that are bound to transferrin and circulating in the blood. This test should be done after 12 hours of fasting. The extent to which sites on transferrin molecules are filled by iron ions can be another helpful clinical indicator, known as percent transferrin saturation. Another lab test saturates the sample to measure the total amount of transferrin; this test is called total iron-binding capacity (TIBC). These three tests are generally done at the same time, and taken together are an important part of the diagnostic process for conditions such as anemia, iron deficiency anemia, anemia of chronic disease and haemochromatosis. (en) La sidérémie ou fer sérique est le taux de fer en circulation dans le plasma sanguin (55% du volume du sang en moyenne), lié à la transferrine. Le fer sérique n'inclut donc pas le fer fixé à l’hémoglobine à l'intérieur des globules rouges. Le taux normal chez l'adulte moyen est compris entre 0,6 et 1,9 mg/L, soit entre 11 et 34 micromoles/L . (fr) La sideremia esprime la quantità del cosiddetto "ferro circolante", cioè quello legato alla transferrina (proteina responsabile del trasporto del ferro). I valori di riferimento sono molto variabili in base al sesso, all'età, al performance status del soggetto e altre caratteristiche. Solitamente è di 70-170 µg/dL nell'uomo e di 50-150 µg/dL nella donna, ma proprio per questa grande variabilità fisiologica il solo dosaggio della sideremia non ha una significatività elevata in campo diagnostico e a questo devono essere associati altri esami come la ferritinemia e la transferrinemia per avere un quadro completo sul cosiddetto assetto marziale, cioè sul metabolismo e l'omeostasi del ferro nell'organismo. (it) Serumijzer, siderofiline of "transportijzer" is een vrij circulerend ijzer-eiwitcomplex in het bloedplasma waarvan het gehalte een maat is voor de hoeveelheid ijzer die uit het voedsel is opgenomen en de hoeveelheid die via het bloed geredistribueerd wordt in het lichaam. Deze twee factoren beïnvloeden het gemeten ijzergehalte in hoge mate, waardoor de klinische waarde van serumijzer beperkt is. Voor een volledig beeld van de ijzerstatus van een patiënt is het beter ook inzicht te krijgen in de lichaamsijzervoorraad (ferritine-meting) en de ijzerverzadigingswaarde (transferrine-saturatie). * Van ijzergebrek of ijzerdeficiëntie wordt gesproken als de serumijzerwaarden lager dan 10 μmol/l zijn, transferrine-saturatiewaarden kleiner dan 15% zijn en de ferritinewaarden onder de 10 μg/l komen. * Van te veel lichaamsijzer of ijzerstapeling is sprake wanneer de transferrine-saturatie boven de 60% komt en de ferritinewaarden ruim boven de referentiewaarde komen (premenopausale vrouwen >80 μg/l; postmenopausale vrouwen >190 μg/l; volwassen mannen >280 μg/l). (nl) |
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| rdfs:comment | La sidérémie ou fer sérique est le taux de fer en circulation dans le plasma sanguin (55% du volume du sang en moyenne), lié à la transferrine. Le fer sérique n'inclut donc pas le fer fixé à l’hémoglobine à l'intérieur des globules rouges. Le taux normal chez l'adulte moyen est compris entre 0,6 et 1,9 mg/L, soit entre 11 et 34 micromoles/L . (fr) La sideremia esprime la quantità del cosiddetto "ferro circolante", cioè quello legato alla transferrina (proteina responsabile del trasporto del ferro). I valori di riferimento sono molto variabili in base al sesso, all'età, al performance status del soggetto e altre caratteristiche. Solitamente è di 70-170 µg/dL nell'uomo e di 50-150 µg/dL nella donna, ma proprio per questa grande variabilità fisiologica il solo dosaggio della sideremia non ha una significatività elevata in campo diagnostico e a questo devono essere associati altri esami come la ferritinemia e la transferrinemia per avere un quadro completo sul cosiddetto assetto marziale, cioè sul metabolismo e l'omeostasi del ferro nell'organismo. (it) Serum iron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin (90%) and serum ferritin (10%). Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems. 65% of the iron in the body is bound up in hemoglobin molecules in red blood cells. About 4% is bound up in myoglobin molecules. Around 30% of the iron in the body is stored as ferritin or hemosiderin in the spleen, the bone marrow and the liver. Small amounts of iron can be found in other molecules in cells throughout the body. None of this iron is directly accessible by testing the serum.} (en) Serumijzer, siderofiline of "transportijzer" is een vrij circulerend ijzer-eiwitcomplex in het bloedplasma waarvan het gehalte een maat is voor de hoeveelheid ijzer die uit het voedsel is opgenomen en de hoeveelheid die via het bloed geredistribueerd wordt in het lichaam. Deze twee factoren beïnvloeden het gemeten ijzergehalte in hoge mate, waardoor de klinische waarde van serumijzer beperkt is. Voor een volledig beeld van de ijzerstatus van een patiënt is het beter ook inzicht te krijgen in de lichaamsijzervoorraad (ferritine-meting) en de ijzerverzadigingswaarde (transferrine-saturatie). (nl) |
| rdfs:label | Fer sérique (fr) Sideremia (it) Serumijzer (nl) Serum iron (en) |
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