Small nucleolar RNA U3 (original) (raw)
In molecular biology, U3 snoRNA is a non-coding RNA found predominantly in the nucleolus.U3 has C/D box motifs that technically make it a member of the box C/D class of snoRNAs; however, unlike other C/D box snoRNAs, it has not been shown to direct 2'-O-methylation of other RNAs.Rather, U3 is thought to guide site-specific cleavage of ribosomal RNA (rRNA) during pre-rRNA processing.
| Property | Value |
|---|---|
| dbo:abstract | In molecular biology, U3 snoRNA is a non-coding RNA found predominantly in the nucleolus.U3 has C/D box motifs that technically make it a member of the box C/D class of snoRNAs; however, unlike other C/D box snoRNAs, it has not been shown to direct 2'-O-methylation of other RNAs.Rather, U3 is thought to guide site-specific cleavage of ribosomal RNA (rRNA) during pre-rRNA processing. The box C/D element is a subset of the six short sequence elements found in all U3 snoRNAs, namely boxes A, A', B, C, C', and D. The U3 snoRNA secondary structure is characterized by a small 5' domain (with boxes A and A'), and a larger 3' domain (with boxes B, C, C', and D), the two domains being linked by a single-stranded hinge. Boxes B and C form the B/C motif, which appears to be exclusive to U3 snoRNAs, and boxes C' and D form the C'/D motif. The latter is functionally similar to the C/D motifs found in other snoRNAs. The 5' domain and the hinge region act as a pre-rRNA-binding domain. The 3' domain has conserved protein-binding sites. Both the box B/C and box C'/D motifs are sufficient for nuclear retention of U3 snoRNA. The box C'/D motif is also necessary for nucleolar localization, stability and hyper-methylation of U3 snoRNA. Both box B/C and C'/D motifs are involved in specific protein interactions and are necessary for the rRNA processing functions of U3 snoRNA. (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Metazoan_U3_secondary_structure.png?width=300 |
| dbo:wikiPageExternalLink | https://www.yeastgenome.org/locus/snR17a http://people.biochem.umass.edu/sfournier/fournierlab/snornadb/snrs/u3_ta.php http://www-snorna.biotoul.fr/plus.php%3Fid=U3 http://rnp.uthscsa.edu/index.html/ |
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| dbo:wikiPageLength | 5517 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1052196513 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Methylation dbr:Human dbr:Saccharomyces_cerevisiae dbr:UTP15 dbr:UTP6 dbr:Nucleolus dbr:Fungi dbr:RRP9 dbc:Small_nuclear_RNA dbr:UTP14A dbr:Eukaryote dbr:Protein dbr:Small_nucleolar_RNA dbr:Plants dbr:Fibrillarin dbr:Metazoa dbr:Molecular_biology dbr:Non-coding_RNA dbr:UTP11L dbr:RCL1 dbr:Ribosomal_RNA dbr:Secondary_structure dbr:SnoRNA dbr:RRNA dbr:3' dbr:5' |
| dbp:altsymbols | RNU3P2, (en) |
| dbp:caption | Metazoan U3 RNA secondary structure and sequence conservation (en) |
| dbp:entrezgene | 26844 (xsd:integer) |
| dbp:hgncid | 10176 (xsd:integer) |
| dbp:id | RF00012 (en) |
| dbp:name | U3 (en) Small nucleolar RNA U3 (en) |
| dbp:omim | 180710 (xsd:integer) |
| dbp:rfam | RF00012 (en) |
| dbp:rnaType | dbr:SnoRNA |
| dbp:symbol | U3 (en) |
| dbp:taxDomain | Eukaryota; (en) |
| dbp:width | 220 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Div_col dbt:Div_col_end dbt:Reflist dbt:Small_nucleolar_RNA dbt:Molecular-biology-stub dbt:Infobox_rfam dbt:Rfam |
| dcterms:subject | dbc:Small_nuclear_RNA |
| gold:hypernym | dbr:RNA |
| rdf:type | dbo:Protein |
| rdfs:comment | In molecular biology, U3 snoRNA is a non-coding RNA found predominantly in the nucleolus.U3 has C/D box motifs that technically make it a member of the box C/D class of snoRNAs; however, unlike other C/D box snoRNAs, it has not been shown to direct 2'-O-methylation of other RNAs.Rather, U3 is thought to guide site-specific cleavage of ribosomal RNA (rRNA) during pre-rRNA processing. (en) |
| rdfs:label | Small nucleolar RNA U3 (en) |
| owl:sameAs | freebase:Small nucleolar RNA U3 wikidata:Small nucleolar RNA U3 https://global.dbpedia.org/id/4uYCG |
| prov:wasDerivedFrom | wikipedia-en:Small_nucleolar_RNA_U3?oldid=1052196513&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Metazoan_U3_secondary_structure.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Small_nucleolar_RNA_U3 |
| is dbo:wikiPageRedirects of | dbr:SnoRNA_U3 |
| is dbo:wikiPageWikiLink of | dbr:Endogenous_retrovirus dbr:UTP15 dbr:UTP18 dbr:Nucleic_acid_sequence dbr:UTP6 dbr:IMP3 dbr:RRP9 dbr:U3 dbr:UTP14A dbr:Biomolecular_structure dbr:Fibrillarin dbr:SmY_RNA dbr:UTP11L dbr:RCL1 dbr:SnoRNA_U3 |
| is foaf:primaryTopic of | wikipedia-en:Small_nucleolar_RNA_U3 |
