Sodium phenylbutyrate/ursodoxicoltaurine (original) (raw)
Sodium phenylbutyrate/ursodoxicoltaurine, also known as sodium phenylbutyrate/taurursodiol and sold under the brand name Albrioza among others, is a fixed-dose combination medication used for the treatment of amyotrophic lateral sclerosis (ALS). It contains sodium phenylbutyrate and ursodoxicoltaurine (taurursodiol). The most common adverse reactions experienced with sodium phenylbutyrate/ursodoxicoltaurine include diarrhea, abdominal pain, nausea and upper respiratory tract infection.
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| dbo:abstract | Sodium phenylbutyrate/ursodoxicoltaurine, also known as sodium phenylbutyrate/taurursodiol and sold under the brand name Albrioza among others, is a fixed-dose combination medication used for the treatment of amyotrophic lateral sclerosis (ALS). It contains sodium phenylbutyrate and ursodoxicoltaurine (taurursodiol). The most common adverse reactions experienced with sodium phenylbutyrate/ursodoxicoltaurine include diarrhea, abdominal pain, nausea and upper respiratory tract infection. Sodium phenylbutyrate/ursodoxicoltaurine acts by blocking cell death pathways in mitochondria and in the endoplasmic reticulum. Sodium phenylbutyrate is a chemical chaperone that helps proteins maintain their normal conformation, preventing aggregation that may lead to cell death. Ursodoxicoltaurine improves mitochondrial energy production. The combination was approved for medical use in Canada as Albrioza, in June 2022, and in the United States, as Relyvrio, in September 2022. (en) |
| dbo:alternativeName | Albrioza, Relyvrio (en) |
| dbo:kegg | D12439 |
| dbo:wikiPageExternalLink | https://druginfo.nlm.nih.gov/drugportal/name/sodium%20phenylbutyrate https://druginfo.nlm.nih.gov/drugportal/name/taurursodiol |
| dbo:wikiPageID | 67961810 (xsd:integer) |
| dbo:wikiPageLength | 15765 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1122679027 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Endoplasmic_reticulum dbr:Priority_review dbr:Ursodoxicoltaurine dbr:Protein_aggregation dbr:Chemical_chaperone dbr:Oral_administration dbr:Orphan_drug dbr:Mitochondria dbr:Amylyx_Pharmaceuticals dbr:Amyotrophic_lateral_sclerosis dbc:Drugs_acting_on_the_nervous_system dbc:Orphan_drugs dbr:Alzheimer's_disease dbr:Food_and_Drug_Administration dbr:Cell_death dbr:Histone_deacetylase_inhibitor dbr:Protein_conformation dbc:Combination_drugs dbr:Bile_acid dbr:Wolfram_syndrome dbr:Sodium_phenylbutyrate dbr:Fixed-dose_combination dbr:Indicated |
| dbp:atcPrefix | None (en) |
| dbp:class | dbr:Bile_acid Pan-histone deacetylase inhibitor (en) |
| dbp:component | Sodium phenylbutyrate (en) Ursodoxicoltaurine (en) |
| dbp:kegg | D12439 (en) |
| dbp:legalCa | Rx-only (en) |
| dbp:legalUs | Rx-only (en) |
| dbp:routesOfAdministration | dbr:Oral_administration |
| dbp:synonyms | AMX0035 (en) |
| dbp:tradename | Albrioza, Relyvrio (en) |
| dbp:type | combo (en) |
| dbp:wikiPageUsesTemplate | dbt:Cite_web dbt:Infobox_drug dbt:Portal_bar dbt:Reflist dbt:Use_American_English dbt:Use_dmy_dates |
| dct:subject | dbc:Drugs_acting_on_the_nervous_system dbc:Orphan_drugs dbc:Combination_drugs |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:CombinationDrug dbo:Drug |
| rdfs:comment | Sodium phenylbutyrate/ursodoxicoltaurine, also known as sodium phenylbutyrate/taurursodiol and sold under the brand name Albrioza among others, is a fixed-dose combination medication used for the treatment of amyotrophic lateral sclerosis (ALS). It contains sodium phenylbutyrate and ursodoxicoltaurine (taurursodiol). The most common adverse reactions experienced with sodium phenylbutyrate/ursodoxicoltaurine include diarrhea, abdominal pain, nausea and upper respiratory tract infection. (en) |
| rdfs:label | Sodium phenylbutyrate/ursodoxicoltaurine (en) |
| owl:sameAs | wikidata:Sodium phenylbutyrate/ursodoxicoltaurine https://global.dbpedia.org/id/FvjeG |
| prov:wasDerivedFrom | wikipedia-en:Sodium_phenylbutyrate/ursodoxicoltaurine?oldid=1122679027&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Sodium_phenylbutyrate/ursodoxicoltaurine |
| is dbo:wikiPageRedirects of | dbr:AMX0035 dbr:Sodium_phenylbutyrate/taurursodiol dbr:Albrioza dbr:Relyvrio |
| is dbo:wikiPageWikiLink of | dbr:Ursodoxicoltaurine dbr:Amylyx_Pharmaceuticals dbr:AMX0035 dbr:Sodium_phenylbutyrate/taurursodiol dbr:Albrioza dbr:Relyvrio |
| is foaf:primaryTopic of | wikipedia-en:Sodium_phenylbutyrate/ursodoxicoltaurine |