| dbo:abstract |
نيزولديبين (بالإنجليزية: Nisoldipine) هو دواء يُستعمل في علاج: * ارتفاع ضغط الدم * ذبحة صدرية (ar) Nisoldipin (INN) ist ein Dihydropyridinderivat. Es wird in der Medizin als blutdrucksenkendes Mittel und zur Therapie der koronaren Herzkrankheit verwendet. (de) El nisoldipino, o nisoldipina, es una dihidropiridina bloqueante de los canales de calcio con acciones y usos similares a los de la nifedipina. (es) La nisoldipine est une molécule de la famille des dihydropyridines qui a un effet antagoniste du calcium. Elle est principalement utilisée comme médicament antihypertenseur. (fr) Nisoldipine is a pharmaceutical drug used for the treatment of chronic angina pectoris and hypertension. It is a calcium channel blocker of the dihydropyridine class. It is sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels. It was patented in 1975 and approved for medical use in 1990. (en) La nisoldipina è un principio attivo della famiglia delle diidropiridine di indicazione specifica contro l'ipertensione. (it) ニソルジピン（国際一般名、英: Nisoldipine）は、系カルシウムチャネル拮抗薬の一つ。ドイツのバイエル社により研究開発され、1990年4月よりバイエル薬品より発売された。日本ではバイミカード®の商品名で5mgと10mgの錠剤が販売されている。 (ja) Nizoldypina (łac. nisoldipinum) – wielofunkcyjny organiczny związek chemiczny z grupy pirydyn, lek stosowany w leczeniu nadciśnienia tętniczego, o działaniu blokującym wolne kanały wapniowe. (pl) |
| dbo:alternativeName |
Sular, Baymycard, Syscor (en) |
| dbo:bioavailability |
4.000000 (xsd:float) |
| dbo:casNumber |
63675-72-9 |
| dbo:chEBI |
7577 |
| dbo:chEMBL |
1726 |
| dbo:drugbank |
DB00401 |
| dbo:fdaUniiCode |
4I8HAB65SZ |
| dbo:kegg |
D00618 |
| dbo:medlinePlus |
a696009 |
| dbo:pubchem |
4499 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Nisoldipine_structure.svg?width=300 |
| dbo:wikiPageID |
6049429 (xsd:integer) |
| dbo:wikiPageLength |
5105 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
992236051 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Carbamazepine dbr:Hypertension dbr:Rifampicin dbr:United_States dbr:L-type_calcium_channel dbc:Carboxylate_esters dbc:Dihydropyridines dbc:Nitrobenzenes dbr:Myocardial_infarction dbr:Lactation dbr:Angina_pectoris dbr:Angioedema dbr:Calcium_channel_blocker dbc:Calcium_channel_blockers dbr:Edema dbr:Cardiogenic_shock dbr:Grapefruit_juice dbr:Ketoconazole dbr:Dihydropyridine dbr:CYP3A4 dbr:Proprietary_name |
| dbp:alt |
Ball-and-stick model of the nisoldipine molecule (en) Skeletal formula of nisoldipine (en) |
| dbp:atcPrefix |
8.0 (dbd:nicaraguanCórdoba) |
| dbp:atcSuffix |
CA07 (en) |
| dbp:bioavailability |
4 (xsd:integer) |
| dbp:c |
20 (xsd:integer) |
| dbp:casNumber |
63675 (xsd:integer) |
| dbp:chebi |
7577 (xsd:integer) |
| dbp:chembl |
1726 (xsd:integer) |
| dbp:chemspiderid |
4343 (xsd:integer) |
| dbp:drugbank |
DB00401 (en) |
| dbp:eliminationHalfLife |
-43200.0 (dbd:second) |
| dbp:excretion |
70 (xsd:integer) |
| dbp:h |
24 (xsd:integer) |
| dbp:image |
Nisoldipine-3D-balls.png (en) |
| dbp:iupacName |
-Isobutyl methyl 2,6-dimethyl-4--1,4-dihydropyridine-3,5-dicarboxylate (en) |
| dbp:iupharLigand |
2524 (xsd:integer) |
| dbp:kegg |
D00618 (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:medlineplus |
a696009 (en) |
| dbp:metabolism |
dbr:CYP3A4 |
| dbp:molecularWeight |
388.414000 (xsd:double) |
| dbp:n |
2 (xsd:integer) |
| dbp:o |
6 (xsd:integer) |
| dbp:pregnancyUs |
C (en) |
| dbp:proteinBound |
>99% (en) |
| dbp:pubchem |
4499 (xsd:integer) |
| dbp:routesOfAdministration |
Oral (en) |
| dbp:smiles |
CC1=CCOC (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
VKQFCGNPDRICFG-UHFFFAOYSA-N (en) |
| dbp:tradename |
Sular, Baymycard, Syscor (en) |
| dbp:unii |
4 (xsd:integer) |
| dbp:verifiedfields |
changed (en) |
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408341052 (xsd:integer) |
| dbp:width |
240 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Cite_journal dbt:Drugbox dbt:Reflist dbt:See dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Xenobiotic-sensing_receptor_modulators dbt:Drugs.com dbt:Ion_channel_modulators dbt:DiseasesDB |
| dct:subject |
dbc:Carboxylate_esters dbc:Dihydropyridines dbc:Nitrobenzenes dbc:Calcium_channel_blockers |
| gold:hypernym |
dbr:Blocker |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatCarboxylateEsters yago:WikicatMolecularFormulas yago:WikicatNitrobenzenes yago:Abstraction100002137 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Ester114850483 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:Nitrobenzene114963486 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Statement106722453 yago:Substance100019613 umbel-rc:DrugProduct |
| rdfs:comment |
نيزولديبين (بالإنجليزية: Nisoldipine) هو دواء يُستعمل في علاج: * ارتفاع ضغط الدم * ذبحة صدرية (ar) Nisoldipin (INN) ist ein Dihydropyridinderivat. Es wird in der Medizin als blutdrucksenkendes Mittel und zur Therapie der koronaren Herzkrankheit verwendet. (de) El nisoldipino, o nisoldipina, es una dihidropiridina bloqueante de los canales de calcio con acciones y usos similares a los de la nifedipina. (es) La nisoldipine est une molécule de la famille des dihydropyridines qui a un effet antagoniste du calcium. Elle est principalement utilisée comme médicament antihypertenseur. (fr) Nisoldipine is a pharmaceutical drug used for the treatment of chronic angina pectoris and hypertension. It is a calcium channel blocker of the dihydropyridine class. It is sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels. It was patented in 1975 and approved for medical use in 1990. (en) La nisoldipina è un principio attivo della famiglia delle diidropiridine di indicazione specifica contro l'ipertensione. (it) ニソルジピン（国際一般名、英: Nisoldipine）は、系カルシウムチャネル拮抗薬の一つ。ドイツのバイエル社により研究開発され、1990年4月よりバイエル薬品より発売された。日本ではバイミカード®の商品名で5mgと10mgの錠剤が販売されている。 (ja) Nizoldypina (łac. nisoldipinum) – wielofunkcyjny organiczny związek chemiczny z grupy pirydyn, lek stosowany w leczeniu nadciśnienia tętniczego, o działaniu blokującym wolne kanały wapniowe. (pl) |
| rdfs:label |
نيزولديبين (ar) Nisoldipin (de) Nisoldipino (es) Nisoldipine (fr) Nisoldipina (it) ニソルジピン (ja) Nisoldipine (en) Nizoldypina (pl) |
| owl:sameAs |
freebase:Nisoldipine http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00401 yago-res:Nisoldipine http://www4.wiwiss.fu-berlin.de/sider/resource/drugs/4499 wikidata:Nisoldipine dbpedia-ar:Nisoldipine dbpedia-cy:Nisoldipine dbpedia-de:Nisoldipine dbpedia-es:Nisoldipine dbpedia-fa:Nisoldipine dbpedia-fr:Nisoldipine dbpedia-it:Nisoldipine dbpedia-ja:Nisoldipine dbpedia-pl:Nisoldipine dbpedia-ro:Nisoldipine dbpedia-sh:Nisoldipine dbpedia-sr:Nisoldipine dbpedia-tr:Nisoldipine dbpedia-vi:Nisoldipine https://global.dbpedia.org/id/35zi3 |
| prov:wasDerivedFrom |
wikipedia-en:Nisoldipine?oldid=992236051&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Nisoldipine-3D-balls.png wiki-commons:Special:FilePath/Nisoldipine_structure.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Nisoldipine |
| is dbo:wikiPageRedirects of |
dbr:Syscor dbr:C20H24N2O6 dbr:Baymycard dbr:ATC_code_C08CA07 dbr:ATCvet_code_QC08CA07 dbr:Nisocor dbr:Zadipina |
| is dbo:wikiPageWikiLink of |
dbr:Antihypertensive_drug dbr:Syscor dbr:Calcium_channel_blocker dbr:Sular dbr:C20H24N2O6 dbr:Baymycard dbr:Dihydropyridine_calcium_channel_blockers dbr:Grapefruit–drug_interactions dbr:List_of_MeSH_codes_(D03) dbr:ATC_code_C08CA07 dbr:ATCvet_code_QC08CA07 dbr:Itraconazole dbr:ATC_code_C08 dbr:Ketoconazole dbr:CYP3A4 dbr:Nisocor dbr:List_of_drugs:_Ni dbr:List_of_drugs:_Suc–Sul dbr:Zadipina |
| is foaf:primaryTopic of |
wikipedia-en:Nisoldipine |
