TRAMP complex (original) (raw)
TRAMP complex (Trf4/Air2/Mtr4p Polyadenylation complex) is a multiprotein, heterotrimeric complex having distributive polyadenylation activity and identifies wide varieties of RNAs produced by polymerases. It was originally discovered in Saccharomyces cerevisiae by LaCava et al., Vanacova et al. and Wyers et al. in 2005. In this way, TRAMP plays a critical role in ridding the cell of noncoding transcripts generated through pervasive RNA polymerase II transcription, as well as functioning in the biogenesis and turnover of functional coding and noncoding RNAs.
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| dbo:abstract | TRAMP complex (Trf4/Air2/Mtr4p Polyadenylation complex) is a multiprotein, heterotrimeric complex having distributive polyadenylation activity and identifies wide varieties of RNAs produced by polymerases. It was originally discovered in Saccharomyces cerevisiae by LaCava et al., Vanacova et al. and Wyers et al. in 2005. It interacts with the exosome complex in the nucleus of eukaryotic cells and is involved in the 3' end processing and degradation of ribosomal RNA and snoRNAs. The TRAMP complex trims the poly(A) tails of RNAs destined for Rrp6 and the core exosome down to 4-5 adenosines assisting in transcript recognition and exosome complex activation. The substrate specificity of exosomes is improved in the presence of TRAMP complex as it acts as a crucial cofactor and helps in maintaining various activities. In this way, TRAMP plays a critical role in ridding the cell of noncoding transcripts generated through pervasive RNA polymerase II transcription, as well as functioning in the biogenesis and turnover of functional coding and noncoding RNAs. TRAMP complex also affects various other RNA processes either directly or indirectly. It is involved in RNA export, Splicing, hetero-chromatic gene silencing and helps in maintaining stability of genome. (en) TRAMP-комплекс (англ. Trf4/Air2/Mtr4p Polyadenylation complex) — мультибелковый комплекс, который состоит из РНК хеликазы (Mtr4/Dob1), поли(A) полимеразы (Trf4 или Trf5) и белка типа цинковый кулачок (Air1 или Air2). Комплекс TRAMP взаимодействует с комплексом экзососмы в ядре эукариотической клетки и участвует в 3'-концевом процессинге и деградации рибосомальной РНК и малых ядрышковых РНК Исходно открытый в дрожжах Saccharomyces cerevisiae, комплекс TRAMP пришивает короткие последовательности из 4-5 аденозинов к концу РНК, в результате чего они разрушаются экзосомой. Таким образом, TRAMP избавляет клетку от некодирующих транскриптов, сгенерированных РНК-полимеразой II, а также участвует в биогенезе и круговороте кодирующих и некодирующих РНК. (ru) |
| dbo:thumbnail | wiki-commons:Special:FilePath/TRAMP.png?width=300 |
| dbo:wikiPageExternalLink | http://smart.embl.de/smart/do_annotation.pl%3FDOMAIN=SM00739 http://www.wikigenes.org/e/gene/e/850401.html https://www.ncbi.nlm.nih.gov/gene/30033105 https://www.uniprot.org/uniprot/E7NI20 https://www.uniprot.org/uniprot/G4U4J3 https://www.uniprot.org/uniprot/O13833 https://www.uniprot.org/uniprot/Q0W2Y8 https://www.uniprot.org/uniprot/Q5XG87 https://www.yeastgenome.org/locus/RRP45 https://www.yeastgenome.org/locus/RRP46 https://www.yeastgenome.org/locus/S000005527 |
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| dbo:wikiPageWikiLink | dbr:Saccharomyces_cerevisiae dbr:Gene_silencing dbr:Transfer_RNA dbr:RNA_splicing dbr:RNA_polymerase_II dbr:Schizosaccharomyces_pombe dbr:Small_nuclear_RNA dbr:DExD/H_box_proteins dbr:Helicase dbr:Helix_bundle dbr:Topoisomerase dbc:Protein_complexes dbr:Eukaryotic dbr:Cell_nucleus dbr:Chromatin dbr:Helix-turn-helix dbr:Small_nucleolar_RNA dbr:RNA_recognition_motif dbr:Biogenesis dbr:Methyltransferase dbr:Transforming_growth_factor_beta_superfamily dbr:Exosome_complex dbr:Polyadenylation dbr:Ribosomal_RNA dbr:Ski_complex dbr:SnoRNA dbr:3'_end dbr:File:TRAMP.png |
| dct:subject | dbc:Protein_complexes |
| rdf:type | yago:Abstraction100002137 yago:Cognition100023271 yago:Complex105870365 yago:Concept105835747 yago:Content105809192 yago:Idea105833840 yago:PsychologicalFeature100023100 yago:Whole105869584 yago:WikicatProteinComplexes |
| rdfs:comment | TRAMP complex (Trf4/Air2/Mtr4p Polyadenylation complex) is a multiprotein, heterotrimeric complex having distributive polyadenylation activity and identifies wide varieties of RNAs produced by polymerases. It was originally discovered in Saccharomyces cerevisiae by LaCava et al., Vanacova et al. and Wyers et al. in 2005. In this way, TRAMP plays a critical role in ridding the cell of noncoding transcripts generated through pervasive RNA polymerase II transcription, as well as functioning in the biogenesis and turnover of functional coding and noncoding RNAs. (en) TRAMP-комплекс (англ. Trf4/Air2/Mtr4p Polyadenylation complex) — мультибелковый комплекс, который состоит из РНК хеликазы (Mtr4/Dob1), поли(A) полимеразы (Trf4 или Trf5) и белка типа цинковый кулачок (Air1 или Air2). Комплекс TRAMP взаимодействует с комплексом экзососмы в ядре эукариотической клетки и участвует в 3'-концевом процессинге и деградации рибосомальной РНК и малых ядрышковых РНК (ru) |
| rdfs:label | TRAMP complex (en) TRAMP-комплекс (ru) |
| owl:sameAs | freebase:TRAMP complex yago-res:TRAMP complex wikidata:TRAMP complex dbpedia-ru:TRAMP complex https://global.dbpedia.org/id/4vnrp |
| prov:wasDerivedFrom | wikipedia-en:TRAMP_complex?oldid=1093348686&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/TRAMP.png |
| foaf:isPrimaryTopicOf | wikipedia-en:TRAMP_complex |
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| is foaf:primaryTopic of | wikipedia-en:TRAMP_complex |
