TROX-1 (original) (raw)
TROX-1 is a drug which acts as a potent blocker of the Cav2 type calcium channels. It was developed as a potential analgesic after the discovery that the selective Cav2.2 blocker ziconotide is an active analgesic with similar efficacy to strong opioid drugs. Unlike ziconotide, TROX-1 is not so selective, and also blocks the Cav2.1 and Cav2.3 calcium channel subtypes, but it has the great advantage of being orally active, whereas ziconotide must be administered intrathecally, by injection into the spinal fluid. In animal studies of TROX-1, analgesic effects were observed with similar efficacy to NSAIDs such as naproxen or diclofenac, and anti-allodynia effects equivalent to pregabalin or duloxetine.
| Property | Value |
|---|---|
| dbo:abstract | TROX-1 is a drug which acts as a potent blocker of the Cav2 type calcium channels. It was developed as a potential analgesic after the discovery that the selective Cav2.2 blocker ziconotide is an active analgesic with similar efficacy to strong opioid drugs. Unlike ziconotide, TROX-1 is not so selective, and also blocks the Cav2.1 and Cav2.3 calcium channel subtypes, but it has the great advantage of being orally active, whereas ziconotide must be administered intrathecally, by injection into the spinal fluid. In animal studies of TROX-1, analgesic effects were observed with similar efficacy to NSAIDs such as naproxen or diclofenac, and anti-allodynia effects equivalent to pregabalin or duloxetine. (en) |
| dbo:casNumber | 1141080-15-0 |
| dbo:fdaUniiCode | GWS86V23Q8 |
| dbo:pubchem | 25256198 |
| dbo:thumbnail | wiki-commons:Special:FilePath/TROX-1_structure.png?width=300 |
| dbo:wikiPageID | 29733245 (xsd:integer) |
| dbo:wikiPageLength | 3810 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1007045694 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Pregabalin dbr:Allodynia dbr:Voltage-dependent_calcium_channel dbr:R-type_calcium_channel dbr:NSAID dbr:Calcium_channel_blocker dbr:Ziconotide dbr:Cav2.1 dbr:Analgesic dbc:Calcium_channel_blockers dbr:Duloxetine dbr:Diclofenac dbr:Naproxen dbr:Opioid dbr:N-type_calcium_channel dbr:Intrathecally |
| dbp:c | 22 (xsd:integer) |
| dbp:casNumber | 1141080 (xsd:integer) |
| dbp:chemspiderid | 24750794 (xsd:integer) |
| dbp:cl | 1 (xsd:integer) |
| dbp:f | 1 (xsd:integer) |
| dbp:h | 16 (xsd:integer) |
| dbp:iupacName | -5 (xsd:integer) |
| dbp:n | 6 (xsd:integer) |
| dbp:o | 1 (xsd:integer) |
| dbp:pubchem | 25256198 (xsd:integer) |
| dbp:smiles | C[C@]5CNc4ccccc45 (en) |
| dbp:unii | GWS86V23Q8 (en) |
| dbp:width | 220 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Calcium_channel_blockers dbt:Drugbox dbt:Reflist dbt:Fdacite dbt:Cardiovascular-drug-stub |
| dcterms:subject | dbc:Calcium_channel_blockers |
| gold:hypernym | dbr:Drug |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatCalciumChannelBlockers yago:Athlete109820263 yago:Blocker109860248 yago:CausalAgent100007347 yago:Contestant109613191 yago:FootballPlayer110101634 yago:LivingThing100004258 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:Player110439851 yago:YagoLegalActor yago:YagoLegalActorGeo dbo:Drug yago:Whole100003553 |
| rdfs:comment | TROX-1 is a drug which acts as a potent blocker of the Cav2 type calcium channels. It was developed as a potential analgesic after the discovery that the selective Cav2.2 blocker ziconotide is an active analgesic with similar efficacy to strong opioid drugs. Unlike ziconotide, TROX-1 is not so selective, and also blocks the Cav2.1 and Cav2.3 calcium channel subtypes, but it has the great advantage of being orally active, whereas ziconotide must be administered intrathecally, by injection into the spinal fluid. In animal studies of TROX-1, analgesic effects were observed with similar efficacy to NSAIDs such as naproxen or diclofenac, and anti-allodynia effects equivalent to pregabalin or duloxetine. (en) |
| rdfs:label | TROX-1 (en) |
| owl:sameAs | freebase:TROX-1 yago-res:TROX-1 wikidata:TROX-1 dbpedia-sh:TROX-1 dbpedia-sr:TROX-1 https://global.dbpedia.org/id/4vvqX |
| prov:wasDerivedFrom | wikipedia-en:TROX-1?oldid=1007045694&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/TROX-1_structure.png |
| foaf:isPrimaryTopicOf | wikipedia-en:TROX-1 |
| is dbo:wikiPageWikiLink of | dbr:N-type_calcium_channel |
| is foaf:primaryTopic of | wikipedia-en:TROX-1 |
