TargetScan (original) (raw)
In bioinformatics, TargetScan is a web server that predicts biological targets of microRNAs (miRNAs) by searching for the presence of sites that match the seed region of each miRNA. For many species, other types of sites, known as 3'-compensatory sites are also identified. These miRNA target predictions are regularly updated and improved by the laboratory of David Bartel in conjunction with the Whitehead Institute Bioinformatics and Research Computing Group.
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| dbo:abstract | In bioinformatics, TargetScan is a web server that predicts biological targets of microRNAs (miRNAs) by searching for the presence of sites that match the seed region of each miRNA. For many species, other types of sites, known as 3'-compensatory sites are also identified. These miRNA target predictions are regularly updated and improved by the laboratory of David Bartel in conjunction with the Whitehead Institute Bioinformatics and Research Computing Group. TargetScan includes TargetScanHuman, TargetScanMouse, TargetScanFish, TargetScanFly, and TargetScanWorm. which provide predictions for mammals, zebrafish, insects, and nematodes centered on the genes of human, mouse, zebrafish, Drosophila melanogaster, and Caenorhabditis elegans, respectively. Compared to other target-prediction tools TargetScan provides accurate rankings of the predicted targets for each miRNA. These rankings are based on either the probability of evolutionarily conserved targeting (PCT scores.) or the predicted efficacy of repression (context++ scores). Another distinguishing feature of TargetScan is its use of extra mRNA annotations. In particular, TargetScanWorm and TargetScanFish are based on C. elegans and zebrafish mRNA models for which 3' untranslated regions (3' UTRs) are defined using polyadenylation sites that are experimentally determined using accurate high-throughput methods. (en) |
| dbo:title | TargetScan (en) |
| dbo:wikiPageExternalLink | http://www.targetscan.org http://www.mirbase.org/ http://www.targetscan.org/ http://bartellab.wi.mit.edu/ |
| dbo:wikiPageID | 41328412 (xsd:integer) |
| dbo:wikiPageLength | 6737 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1053699194 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Caenorhabditis_elegans dbr:Three_prime_untranslated_region dbc:MicroRNA dbr:David_Bartel dbr:Zebrafish dbc:Servers_(computing) dbr:Whitehead_Institute dbr:Drosophila_melanogaster dbc:Biological_databases dbr:Bioinformatics dbr:Polyadenylation dbr:MicroRNAs |
| dbp:description | dbr:MicroRNAs (en) |
| dbp:laboratory | David Bartel Lab (en) |
| dbp:title | TargetScan (en) |
| dbp:url | http://www.targetscan.org |
| dbp:wikiPageUsesTemplate | dbt:Infobox_biodatabase dbt:Citation_needed dbt:Reflist dbt:Which dbt:Compared_to? |
| dc:description | microRNAs |
| dct:subject | dbc:MicroRNA dbc:Servers_(computing) dbc:Biological_databases |
| gold:hypernym | dbr:Server |
| rdf:type | owl:Thing dbo:Software schema:CreativeWork dbo:Work wikidata:Q386724 dbo:Database dul:InformationObject dbo:BiologicalDatabase |
| rdfs:comment | In bioinformatics, TargetScan is a web server that predicts biological targets of microRNAs (miRNAs) by searching for the presence of sites that match the seed region of each miRNA. For many species, other types of sites, known as 3'-compensatory sites are also identified. These miRNA target predictions are regularly updated and improved by the laboratory of David Bartel in conjunction with the Whitehead Institute Bioinformatics and Research Computing Group. (en) |
| rdfs:label | TargetScan (en) |
| owl:sameAs | freebase:TargetScan wikidata:TargetScan https://global.dbpedia.org/id/mm3Z |
| prov:wasDerivedFrom | wikipedia-en:TargetScan?oldid=1053699194&ns=0 |
| foaf:homepage | http://www.targetscan.org |
| foaf:isPrimaryTopicOf | wikipedia-en:TargetScan |
| is dbo:wikiPageWikiLink of | dbr:David_Bartel dbr:RNA_therapeutics dbr:TM6SF2 dbr:Cross-linking_immunoprecipitation dbr:MiR-137 dbr:MicroRNA_and_microRNA_target_database dbr:MicroRNA_sequencing dbr:List_of_RNA_structure_prediction_software dbr:C6orf136 dbr:TMEM98 |
| is foaf:primaryTopic of | wikipedia-en:TargetScan |