Testifenon (original) (raw)
Testifenon, also known as testiphenon, testiphenone, chlorphenacyl dihydrotestosterone ester, or dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic anabolic–androgenic steroid (AAS) and a cytostatic antineoplastic agent (i.e., chemotherapeutic) that was never marketed. It is an androgen ester – specifically, a chlorphenacyl nitrogen mustard ester of dihydrotestosterone (DHT) – and acts as a prodrug of these two components in the body. The drug was developed in Russia as a tissue-selective cytostatic drug for the treatment of various cancers occurring in androgen receptor-expressing tissues that would have reduced side effects and toxicity relative to other chemotherapy drugs.
| Property | Value |
|---|---|
| dbo:abstract | Testifenon, also known as testiphenon, testiphenone, chlorphenacyl dihydrotestosterone ester, or dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic anabolic–androgenic steroid (AAS) and a cytostatic antineoplastic agent (i.e., chemotherapeutic) that was never marketed. It is an androgen ester – specifically, a chlorphenacyl nitrogen mustard ester of dihydrotestosterone (DHT) – and acts as a prodrug of these two components in the body. The drug was developed in Russia as a tissue-selective cytostatic drug for the treatment of various cancers occurring in androgen receptor-expressing tissues that would have reduced side effects and toxicity relative to other chemotherapy drugs. (en) |
| dbo:casNumber | 104730-58-7 |
| dbo:fdaUniiCode | 3U50JYF0B9 |
| dbo:pubchem | 128659 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Testifenon.svg?width=300 |
| dbo:wikiPageID | 52713783 (xsd:integer) |
| dbo:wikiPageLength | 4591 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 992148871 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Cancer dbr:List_of_androgen_esters dbr:Nitrogen_mustard dbr:Androgen_ester dbr:Androgen_receptor dbc:Dihydrotestosterone_esters dbr:Cytostasis dbr:List_of_hormonal_cytostatic_antineoplastic_agents dbc:Abandoned_drugs dbc:Androgens_and_anabolic_steroids dbc:Androstanes dbc:Organochlorides dbc:Prodrugs dbr:Russia dbr:Ester dbr:Tissue_selectivity dbr:Phenyl_group dbr:Prodrug dbr:Acyl_group dbr:Drug dbr:Cytostatic dbc:Nitrogen_mustards dbc:Antineoplastic_drugs dbc:Russian_drugs dbr:Chemotherapy dbr:Chlorine dbr:Tissue_(biology) dbr:Toxicity dbr:Dihydrotestosterone dbr:Side_effect dbr:Antineoplastic_agent dbr:Anabolic–androgenic_steroid dbr:Synthetic_compound |
| dbp:c | 31 (xsd:integer) |
| dbp:casNumber | 104730 (xsd:integer) |
| dbp:chemspiderid | 114020 (xsd:integer) |
| dbp:cl | 2 (xsd:integer) |
| dbp:h | 43 (xsd:integer) |
| dbp:image | Testifenon molecule ball.png (en) |
| dbp:iupacName | [-10,13-Dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] 2-[4-[bisamino]phenyl]acetate (en) |
| dbp:n | 1 (xsd:integer) |
| dbp:o | 3 (xsd:integer) |
| dbp:pubchem | 128659 (xsd:integer) |
| dbp:smiles | C[C@]12CCCC[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4C (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | JWLXQUMDRGJLMS-SJQIPMMSSA-N (en) |
| dbp:synonyms | Testiphenon; Testiphenone; Chlorphenacyl dihydrotestosterone ester; Dihydrotestosterone 17β-acetate; LS-19378 (en) |
| dbp:unii | 3 (xsd:integer) |
| dbp:width | 250 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Androgen_receptor_modulators dbt:Antineoplastic-drug-stub dbt:Drugbox dbt:Reflist dbt:Steroid-stub dbt:Cascite dbt:Fdacite |
| dct:subject | dbc:Dihydrotestosterone_esters dbc:Abandoned_drugs dbc:Androgens_and_anabolic_steroids dbc:Androstanes dbc:Organochlorides dbc:Prodrugs dbc:Nitrogen_mustards dbc:Antineoplastic_drugs dbc:Russian_drugs |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | Testifenon, also known as testiphenon, testiphenone, chlorphenacyl dihydrotestosterone ester, or dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic anabolic–androgenic steroid (AAS) and a cytostatic antineoplastic agent (i.e., chemotherapeutic) that was never marketed. It is an androgen ester – specifically, a chlorphenacyl nitrogen mustard ester of dihydrotestosterone (DHT) – and acts as a prodrug of these two components in the body. The drug was developed in Russia as a tissue-selective cytostatic drug for the treatment of various cancers occurring in androgen receptor-expressing tissues that would have reduced side effects and toxicity relative to other chemotherapy drugs. (en) |
| rdfs:label | Testifenon (en) |
| owl:sameAs | yago-res:Testifenon wikidata:Testifenon https://global.dbpedia.org/id/2ckhN |
| prov:wasDerivedFrom | wikipedia-en:Testifenon?oldid=992148871&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Testifenon.svg wiki-commons:Special:FilePath/Testifenon_molecule_ball.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Testifenon |
| is dbo:wikiPageRedirects of | dbr:Testifenone dbr:Testiphenon dbr:Testiphenone |
| is dbo:wikiPageWikiLink of | dbr:List_of_androgen_esters dbr:List_of_hormonal_cytostatic_antineoplastic_agents dbr:Testifenone dbr:Testiphenon dbr:Testiphenone |
| is foaf:primaryTopic of | wikipedia-en:Testifenon |
