Tetracenomycin C (original) (raw)
Tetracenomycin C is an antitumor anthracycline-like antibiotic produced by Streptomyces glaucescens GLA.0.The pale-yellow antibiotic is active against some gram-positive bacteria, especially against streptomycetes. Gram-negative bacteria and fungi are not inhibited. In considering the differences of biological activity and the functional groups of the molecule, tetracenomycin C is not a member of the tetracycline or anthracyclinone group of antibiotics. Tetracenomycin C is notable for its broad activity against actinomycetes. As in other anthracycline antibiotics, the framework is synthesized by a polyketide synthase and subsequently modified by other enzymes.
| Property | Value |
|---|---|
| dbo:abstract | Tetracenomycin C is an antitumor anthracycline-like antibiotic produced by Streptomyces glaucescens GLA.0.The pale-yellow antibiotic is active against some gram-positive bacteria, especially against streptomycetes. Gram-negative bacteria and fungi are not inhibited. In considering the differences of biological activity and the functional groups of the molecule, tetracenomycin C is not a member of the tetracycline or anthracyclinone group of antibiotics. Tetracenomycin C is notable for its broad activity against actinomycetes. As in other anthracycline antibiotics, the framework is synthesized by a polyketide synthase and subsequently modified by other enzymes. (en) |
| dbo:iupacName | Methyl (6aR,7S,10aR)-6a,7,10a,12-tetrahydroxy-3,8-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate (en) |
| dbo:wikiPageID | 70925428 (xsd:integer) |
| dbo:wikiPageLength | 5631 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1102841312 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Anthracycline dbr:Hydrogen_bond dbr:Cyclase dbr:DNA dbr:Carbonyl dbr:Intramolecular_force dbc:Alcohols dbc:Antibiotics dbc:Carboxylic_acids dbc:Methoxy_compounds dbc:Naphthalenes dbc:Triketones dbr:Gene_cluster dbr:Ketoacyl_synthase dbr:Actinomycetales dbr:Acyl_carrier_protein dbr:Gram-positive_bacteria dbr:Tetracycline dbr:Biosynthesis dbr:Heterologous dbr:Cis–trans_isomerism dbr:Methanol dbr:Polyketide_synthase dbr:Streptomyces_glaucescens dbr:Streptomycetes dbr:Intermolecular dbr:Carboxymethyl_group dbr:Streptomyces_lividans dbr:File:Biosynthesis_of_Tetracenomycin_C.tif |
| dbp:imagefile | Tetracenomycin C.tif (en) |
| dbp:iupacname | Methyl -6a,7,10a,12-tetrahydroxy-3,8-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate (en) |
| dbp:name | Tetracenomycin C (en) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist |
| dct:subject | dbc:Alcohols dbc:Antibiotics dbc:Carboxylic_acids dbc:Methoxy_compounds dbc:Naphthalenes dbc:Triketones |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | Tetracenomycin C is an antitumor anthracycline-like antibiotic produced by Streptomyces glaucescens GLA.0.The pale-yellow antibiotic is active against some gram-positive bacteria, especially against streptomycetes. Gram-negative bacteria and fungi are not inhibited. In considering the differences of biological activity and the functional groups of the molecule, tetracenomycin C is not a member of the tetracycline or anthracyclinone group of antibiotics. Tetracenomycin C is notable for its broad activity against actinomycetes. As in other anthracycline antibiotics, the framework is synthesized by a polyketide synthase and subsequently modified by other enzymes. (en) |
| rdfs:label | Tetracenomycin C (en) |
| owl:sameAs | wikidata:Tetracenomycin C https://global.dbpedia.org/id/2Y1dk |
| prov:wasDerivedFrom | wikipedia-en:Tetracenomycin_C?oldid=1102841312&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Tetracenomycin_C |
| foaf:name | Tetracenomycin C (en) |
| is dbo:wikiPageWikiLink of | dbr:Streptomyces_glaucescens |
| is foaf:primaryTopic of | wikipedia-en:Tetracenomycin_C |