Thiafentanil (original) (raw)
Thiafentanil (A-3080, Thianil) is a highly potent opioid analgesic that is an analog of fentanyl, and was invented in 1986. Its analgesic potency is slightly less than that of carfentanil (itself approximately 10,000 times the potency of morphine, or 4,000 times that of heroin), though with a faster onset of effects, shorter duration of action and a slightly lesser tendency to produce respiratory depression. It is used in veterinary medicine to anesthetise animals such as impala, usually in combination with other anesthetics such as ketamine, xylazine or medetomidine to reduce the prevalence of side effects such as muscle rigidity.
| Property | Value |
|---|---|
| dbo:abstract | Thiafentanil (A-3080) ist ein hochpotentes und schnellwirkendes Opioid, das zu Betäubung von Wildtieren mit Hilfe von Pfeil-Spritzen verwendet wird. Es ähnelt stark dem Carfentanyl oder Etorphin, unterscheidet sich von diesen aber durch einen schnelleren Wirkungseintritt, eine signifikant kürzere Wirkungsdauer und eine geringere atemdepressorische Potenz unter narkotisch äquivalenten Dosen. Thiafentanil (A-3080) ist ein Analogon des Thiofentanil (R 31826), wobei der Propionyl-Rest gegen einen Methoxyacetyl-Rest ersetzt wurde. Es wurde zusammen mit einer ganze Serie analoger Alkoxyalkanamido-, Furamido- und Thenamido-Derivate 1986 patentiert.Thiafentanil wird seit Ende der 80er Jahre neben Carfentanyl (Wildnil) und Etorphin (M99, Immobilon) in der Veterinärmedizin zur Betäubung von größeren Tieren verwendet. (de) Thiafentanil (A-3080, Thianil) is a highly potent opioid analgesic that is an analog of fentanyl, and was invented in 1986. Its analgesic potency is slightly less than that of carfentanil (itself approximately 10,000 times the potency of morphine, or 4,000 times that of heroin), though with a faster onset of effects, shorter duration of action and a slightly lesser tendency to produce respiratory depression. It is used in veterinary medicine to anesthetise animals such as impala, usually in combination with other anesthetics such as ketamine, xylazine or medetomidine to reduce the prevalence of side effects such as muscle rigidity. (en) |
| dbo:casNumber | 101345-60-2 |
| dbo:fdaUniiCode | HS2D307FGT |
| dbo:pubchem | 13653617 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Formel_von_A-3080.png?width=300 |
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| dbo:wikiPageLength | 5705 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1101254212 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Carfentanil dbr:Potency_(pharmacology) dbr:List_of_fentanyl_analogues dbr:Veterinary_medicine dbr:Structural_analog dbc:Mu-opioid_receptor_agonists dbc:Piperidines dbr:Medetomidine dbr:Nausea dbr:Morphine dbr:Nalmefene dbr:Naltrexone dbr:Sufentanil dbr:Analgesia dbr:Analgesic dbr:Fentanyl dbc:Anilides dbc:Synthetic_opioids dbc:Thiophenes dbr:Heroin dbr:Ketamine dbr:Impala dbr:Opioid dbr:Xylazine dbr:Itching dbr:Muscle_rigidity dbr:Respiratory_depression |
| dbp:c | 22 (xsd:integer) |
| dbp:casNumber | 101345 (xsd:integer) |
| dbp:chemspiderid | 58828132 (xsd:integer) |
| dbp:h | 28 (xsd:integer) |
| dbp:image | Thiafentanil.png (en) |
| dbp:iupacName | methyl 4--1-piperidine-4-carboxylate (en) |
| dbp:legalCa | Schedule I (en) |
| dbp:legalUk | Class A (en) |
| dbp:legalUs | Schedule II (en) |
| dbp:n | 2 (xsd:integer) |
| dbp:o | 4 (xsd:integer) |
| dbp:pubchem | 13653617 (xsd:integer) |
| dbp:s | 1 (xsd:integer) |
| dbp:smiles | COCCNC2COC (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | HFRKHTCPWUOGHM-UHFFFAOYSA-N (en) |
| dbp:unii | HS2D307FGT (en) |
| dbp:wikiPageUsesTemplate | dbt:Distinguish dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Opioid_receptor_modulators |
| dct:subject | dbc:Mu-opioid_receptor_agonists dbc:Piperidines dbc:Anilides dbc:Synthetic_opioids dbc:Thiophenes |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | Thiafentanil (A-3080, Thianil) is a highly potent opioid analgesic that is an analog of fentanyl, and was invented in 1986. Its analgesic potency is slightly less than that of carfentanil (itself approximately 10,000 times the potency of morphine, or 4,000 times that of heroin), though with a faster onset of effects, shorter duration of action and a slightly lesser tendency to produce respiratory depression. It is used in veterinary medicine to anesthetise animals such as impala, usually in combination with other anesthetics such as ketamine, xylazine or medetomidine to reduce the prevalence of side effects such as muscle rigidity. (en) Thiafentanil (A-3080) ist ein hochpotentes und schnellwirkendes Opioid, das zu Betäubung von Wildtieren mit Hilfe von Pfeil-Spritzen verwendet wird. Es ähnelt stark dem Carfentanyl oder Etorphin, unterscheidet sich von diesen aber durch einen schnelleren Wirkungseintritt, eine signifikant kürzere Wirkungsdauer und eine geringere atemdepressorische Potenz unter narkotisch äquivalenten Dosen. (de) |
| rdfs:label | Thiafentanil (de) Thiafentanil (en) |
| owl:differentFrom | dbr:Thiofentanyl |
| owl:sameAs | wikidata:Thiafentanil dbpedia-de:Thiafentanil https://global.dbpedia.org/id/2XaYx |
| prov:wasDerivedFrom | wikipedia-en:Thiafentanil?oldid=1101254212&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Thiafentanil.png wiki-commons:Special:FilePath/Formel_von_A-3080.png |
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| is owl:differentFrom of | dbr:Thiofentanyl |
| is foaf:primaryTopic of | wikipedia-en:Thiafentanil |
