Transcriptome instability (original) (raw)
Transcriptome instability is a genome-wide, pre-mRNA splicing-related characteristic of certain cancers. In general, pre-mRNA splicing is dysregulated in a high proportion of cancerous cells. For certain types of cancer, like in colorectal and prostate, the number of splicing errors per cancer has been shown to vary greatly between individual cancers, a phenomenon referred to as transcriptome instability. Transcriptome instability correlates significantly with reduced expression level of splicing factor genes. Mutation of DNMT3A contributes to development of hematologic malignancies, and DNMT3A-mutated cell lines exhibit transcriptome instability as compared to their isogenic wildtype counterparts.
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| dbo:abstract | Transcriptome instability is a genome-wide, pre-mRNA splicing-related characteristic of certain cancers. In general, pre-mRNA splicing is dysregulated in a high proportion of cancerous cells. For certain types of cancer, like in colorectal and prostate, the number of splicing errors per cancer has been shown to vary greatly between individual cancers, a phenomenon referred to as transcriptome instability. Transcriptome instability correlates significantly with reduced expression level of splicing factor genes. Mutation of DNMT3A contributes to development of hematologic malignancies, and DNMT3A-mutated cell lines exhibit transcriptome instability as compared to their isogenic wildtype counterparts. (en) |
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| dbo:wikiPageWikiLink | dbr:Cancer dbr:Colorectal_cancer dbr:Genome dbr:RNA_splicing dbr:Prostate_cancer dbr:Cell_(biology) dbr:DNMT3A dbc:Gene_expression dbc:RNA_splicing dbc:Cancer dbr:Hematologic_malignancies |
| dbp:wikiPageUsesTemplate | dbt:Reflist |
| dct:subject | dbc:Gene_expression dbc:RNA_splicing dbc:Cancer |
| rdfs:comment | Transcriptome instability is a genome-wide, pre-mRNA splicing-related characteristic of certain cancers. In general, pre-mRNA splicing is dysregulated in a high proportion of cancerous cells. For certain types of cancer, like in colorectal and prostate, the number of splicing errors per cancer has been shown to vary greatly between individual cancers, a phenomenon referred to as transcriptome instability. Transcriptome instability correlates significantly with reduced expression level of splicing factor genes. Mutation of DNMT3A contributes to development of hematologic malignancies, and DNMT3A-mutated cell lines exhibit transcriptome instability as compared to their isogenic wildtype counterparts. (en) |
| rdfs:label | Transcriptome instability (en) |
| owl:sameAs | wikidata:Transcriptome instability https://global.dbpedia.org/id/4Wxgw |
| prov:wasDerivedFrom | wikipedia-en:Transcriptome_instability?oldid=1077172951&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Transcriptome_instability |
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| is foaf:primaryTopic of | wikipedia-en:Transcriptome_instability |