| dbo:abstract |
Transition state analogs (transition state analogues), are chemical compounds with a chemical structure that resembles the transition state of a substrate molecule in an enzyme-catalyzed chemical reaction. Enzymes interact with a substrate by means of strain or distortions, moving the substrate towards the transition state. Transition state analogs can be used as inhibitors in enzyme-catalyzed reactions by blocking the active site of the enzyme. Theory suggests that enzyme inhibitors which resembled the transition state structure would bind more tightly to the enzyme than the actual substrate. Examples of drugs that are transition state analog inhibitors include flu medications such as the neuraminidase inhibitor oseltamivir and the HIV protease inhibitors saquinavir in the treatment of AIDS. (en) 過渡態類似物為在中，和基質分子的過渡狀態有相似化學結構的化合物。 理論顯示酵素抑制劑像過渡態的結構。過渡態類似物可藉由鍵結於酵素活化位，作為酵素反應的酵素抑制劑。像是藥物就是過渡態的類似物抑制劑，包含流感藥物，像是，奧司他韋；蛋白酶抑制劑，沙奎那韋。 (zh) |
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過渡態類似物為在中，和基質分子的過渡狀態有相似化學結構的化合物。 理論顯示酵素抑制劑像過渡態的結構。過渡態類似物可藉由鍵結於酵素活化位，作為酵素反應的酵素抑制劑。像是藥物就是過渡態的類似物抑制劑，包含流感藥物，像是，奧司他韋；蛋白酶抑制劑，沙奎那韋。 (zh) Transition state analogs (transition state analogues), are chemical compounds with a chemical structure that resembles the transition state of a substrate molecule in an enzyme-catalyzed chemical reaction. Enzymes interact with a substrate by means of strain or distortions, moving the substrate towards the transition state. Transition state analogs can be used as inhibitors in enzyme-catalyzed reactions by blocking the active site of the enzyme. Theory suggests that enzyme inhibitors which resembled the transition state structure would bind more tightly to the enzyme than the actual substrate. Examples of drugs that are transition state analog inhibitors include flu medications such as the neuraminidase inhibitor oseltamivir and the HIV protease inhibitors saquinavir in the treatment of AI (en) |
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Transition state analog (en) 過渡態類似物 (zh) |
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