| dbo:abstract |
W-18 is a compound in a series of 32 substances (named W-1 to W-32) that were first synthesized in academic research on analgesic drug discovery in the 1980s and appeared as a designer drug in the 2010s. W-18 was invented at the University of Alberta by a lab working on analgesic drug discovery in the 1980s, and preliminary studies in animals showed it had pain-killing activity in mice. The chemical was detected in connection with recreational drug use as substitute for other controlled substances in Europe in 2013, and in the United States. In Canada, Alberta Law Enforcement Response Teams (ALERT) seized four kilograms of W-18 in a drug bust in Edmonton in December 2015 and W-18 was also detected by Health Canada in at least three of 110 fentanyl tablets seized from a Calgary home in August 2015. W-18 was commonly reported to be an opioid in the popular press in the 2010s, which was later revealed not to be correct. W-18 was found to obtain weak activity at both sigma receptors and the translocator protein (peripheral benzodiazepine receptor). It also inhibits the hERG potassium channel with micromolar affinity, which could potentially cause cardiac arrhythmia at high doses. * In Sweden, W-18 was made illegal in January 2016. * In Canada, W-18 and its analogues were made Schedule I controlled substances. Possession without legal authority can result in maximum 7 years imprisonment. Further, Health Canada amended the Food and Drug Regulations in May, 2016 to classify W-18 as a restricted drug. Only those with a law enforcement agency, person with an exemption permit or institutions with Minister's authorization may possess the drug. (en) |
| dbo:casNumber |
93101-02-1 |
| dbo:fdaUniiCode |
04WOYJF7QH |
| dbo:pubchem |
57501076 |
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dbr:Calgary dbr:Designer_drug dbr:Ro5-4864 dbr:University_of_Alberta dbc:Chloroarenes dbc:Nitrobenzenes dbc:Piperidines dbr:Controlled_substance dbr:Drug_discovery dbr:HERG dbr:Alberta_Law_Enforcement_Response_Teams dbr:Analgesic dbc:Sigma_receptor_ligands dbr:Edmonton dbc:TSPO_ligands dbr:Fentanyl dbr:Health_Canada dbc:Sulfonamides dbr:Opioid dbr:Sigma_receptor dbr:Translocator_protein |
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| dbp:legalStatus |
Illegal in Sweden and Canada (en) |
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C1CCNCCC3=CC=C[N+][O-] (en) |
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BKRSVROQVRTSND-VZCXRCSSSA-N (en) |
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changed (en) |
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| dct:subject |
dbc:Chloroarenes dbc:Nitrobenzenes dbc:Piperidines dbc:Sigma_receptor_ligands dbc:TSPO_ligands dbc:Sulfonamides |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatMolecularFormulas yago:WikicatNitrobenzenes yago:Abstraction100002137 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:Nitrobenzene114963486 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Statement106722453 yago:Substance100019613 umbel-rc:DrugProduct |
| rdfs:comment |
W-18 is a compound in a series of 32 substances (named W-1 to W-32) that were first synthesized in academic research on analgesic drug discovery in the 1980s and appeared as a designer drug in the 2010s. W-18 was invented at the University of Alberta by a lab working on analgesic drug discovery in the 1980s, and preliminary studies in animals showed it had pain-killing activity in mice. (en) |
| rdfs:label |
W-18 (en) |
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freebase:W-18 yago-res:W-18 wikidata:W-18 dbpedia-sh:W-18 dbpedia-sr:W-18 https://global.dbpedia.org/id/4DJxF |
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wikipedia-en:W-18?oldid=1050214169&ns=0 |
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dbr:1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide dbr:C19H20ClN3O4S |
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dbr:List_of_designer_drugs dbr:1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide dbr:Controlled_Drugs_and_Substances_Act dbr:C19H20ClN3O4S dbr:Aero_A.42 dbr:Rachel_Notley |
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wikipedia-en:W-18 |
