Translocator protein (original) (raw)
Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain. In humans, the translocator protein is encoded by the TSPO gene. It belongs to a family of tryptophan-rich sensory proteins. Regarding intramitochondrial cholesterol transport, TSPO has been proposed to interact with StAR (steroidogenic acute regulatory protein) to transport cholesterol into mitochondria, though evidence is mixed.
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| dbo:abstract | TSPO (Abk. von engl. Translocator Protein, oder auch Tryptophan-rich sensory protein), auch bekannt als peripheral benzodiazepine receptor (PBR), ist ein Transmembranprotein der äußeren Mitochondrienmembran mit einer Molekülmasse von 18 kDa. TSPO bindet, wie der GABA-Rezeptor Benzodiazepine. Neben vielen anderen Funktionen ist es an der Regulation der Biosynthese der Steroidhormone sowie der Porphyrine beteiligt und spielt eine Rolle bei der Apoptose. TSPO wurde 1977 entdeckt, als man nach Bindungsstellen für Diazepam in peripheren Geweben suchte. Die Nukleotidsequenz ist hoch konserviert und codiert ein Membranprotein mit wahrscheinlich fünf Transmembranhelices. Homologe Proteine finden sich in Bakterien, Pflanzen und Tieren.Es war lange nicht möglich eine Knockout-Maus zu erzeugen. In Zellen ohne TSPO Gen akkumuliert Protoporphyrin IX in den Mitochondrien, daher nahm man an, dass das Protein lebensnotwendig ist. 2015 gelang es Knockout-Mäuse zu generieren. Ein Knockout-Moos, in dem eines dieser Gene ausgeschaltet wurde, ist lebensfähig, aber anfällig gegen Stress. (de) Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain. In humans, the translocator protein is encoded by the TSPO gene. It belongs to a family of tryptophan-rich sensory proteins. Regarding intramitochondrial cholesterol transport, TSPO has been proposed to interact with StAR (steroidogenic acute regulatory protein) to transport cholesterol into mitochondria, though evidence is mixed. (en) TSPO (англ. Translocator protein) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 22-ї хромосоми. Довжина поліпептидного ланцюга білка становить 102 амінокислот, а молекулярна маса — 10 537. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаG: ГліцинH: ГістидинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у такому біологічному процесі, як альтернативний сплайсинг. (uk) |
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| gold:hypernym | dbr:Protein |
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| rdfs:comment | Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain. In humans, the translocator protein is encoded by the TSPO gene. It belongs to a family of tryptophan-rich sensory proteins. Regarding intramitochondrial cholesterol transport, TSPO has been proposed to interact with StAR (steroidogenic acute regulatory protein) to transport cholesterol into mitochondria, though evidence is mixed. (en) TSPO (англ. Translocator protein) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 22-ї хромосоми. Довжина поліпептидного ланцюга білка становить 102 амінокислот, а молекулярна маса — 10 537. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаG: ГліцинH: ГістидинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у такому біологічному процесі, як альтернативний сплайсинг. (uk) TSPO (Abk. von engl. Translocator Protein, oder auch Tryptophan-rich sensory protein), auch bekannt als peripheral benzodiazepine receptor (PBR), ist ein Transmembranprotein der äußeren Mitochondrienmembran mit einer Molekülmasse von 18 kDa. TSPO bindet, wie der GABA-Rezeptor Benzodiazepine. Neben vielen anderen Funktionen ist es an der Regulation der Biosynthese der Steroidhormone sowie der Porphyrine beteiligt und spielt eine Rolle bei der Apoptose. TSPO wurde 1977 entdeckt, als man nach Bindungsstellen für Diazepam in peripheren Geweben suchte. (de) |
| rdfs:label | TSPO (Protein) (de) Translocator protein (en) TSPO (uk) |
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