| dbo:abstract |
Wasabi receptor toxin (WaTx) is the active component of the venom of the Australian black rock scorpion Urodacus manicatus. WaTx targets TRPA1, also known as the wasabi receptor or irritant receptor. WaTx is a cell-penetrating toxin that stabilizes the TRPA1 channel open state while reducing its Ca2+-permeability, thereby eliciting pain and pain hypersensitivity without the neurogenic inflammation that typically occurs in other animal toxins. (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Urodacus_manicatus2.jpg?width=300 |
| dbo:wikiPageExternalLink |
https://www.rcsb.org/structure/6OFA |
| dbo:wikiPageID |
61980431 (xsd:integer) |
| dbo:wikiPageLength |
17710 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1055241679 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Scorpion dbr:Electrophile dbr:Beta_sheet dbr:Beta_turn dbr:Neuropeptide dbr:Calcitonin_gene-related_peptide dbr:Tat_(HIV) dbr:Transient_receptor_potential_channel dbc:Scorpion_toxins dbr:Alpha_helix dbr:Amino_acid dbr:Non-covalent_interactions dbr:Cell-penetrating_peptide dbr:Dipole dbc:Neurotoxins dbr:Covalent_bond dbr:Hypersensitivity dbc:Ion_channel_toxins dbr:Disulfide dbr:Wasabi dbr:Neurogenic_inflammation dbr:Small_protein dbr:Urodacus_manicatus dbr:TRPA1 dbr:File:Urodacus_manicatus2.jpg |
| dbp:caption |
Australian black rock scorpion . (en) |
| dbp:data |
6 (xsd:integer) dbr:Small_protein Urodacus manicatus (en) Wasabi Receptor Toxin (en) Potassium channel inhibitor KTx (en) Short scorpion toxin (en) kappa-KTx (en) |
| dbp:header |
Wasabi Receptor Toxin . (en) |
| dbp:headerstyle |
background:#ccf; (en) |
| dbp:label |
Family (en) Species (en) PDB (en) Class (en) Protein (en) Subfamily (en) Superfamily (en) |
| dbp:labelstyle |
background:#ddf; (en) |
| dbp:name |
Infobox Wasabi Receptor Toxin (en) |
| dbp:wikiPageUsesTemplate |
dbt:Box dbt:Infobox dbt:Reflist |
| dcterms:subject |
dbc:Scorpion_toxins dbc:Neurotoxins dbc:Ion_channel_toxins |
| rdfs:comment |
Wasabi receptor toxin (WaTx) is the active component of the venom of the Australian black rock scorpion Urodacus manicatus. WaTx targets TRPA1, also known as the wasabi receptor or irritant receptor. WaTx is a cell-penetrating toxin that stabilizes the TRPA1 channel open state while reducing its Ca2+-permeability, thereby eliciting pain and pain hypersensitivity without the neurogenic inflammation that typically occurs in other animal toxins. (en) |
| rdfs:label |
Wasabi receptor toxin (en) |
| owl:sameAs |
wikidata:Wasabi receptor toxin https://global.dbpedia.org/id/C14H9 |
| prov:wasDerivedFrom |
wikipedia-en:Wasabi_receptor_toxin?oldid=1055241679&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Urodacus_manicatus2.jpg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Wasabi_receptor_toxin |
| is dbo:wikiPageRedirects of |
dbr:Wasabi_Receptor_Toxin dbr:WaTx |
| is dbo:wikiPageWikiLink of |
dbr:TRPA1 dbr:Wasabi_Receptor_Toxin dbr:WaTx |
| is foaf:primaryTopic of |
wikipedia-en:Wasabi_receptor_toxin |
