| dbo:abstract |
The carboxypeptidase A family can be divided into two subfamilies: carboxypeptidase H (regulatory) and carboxypeptidase A (digestive). Members of the H family have longer C-termini than those of family A, and carboxypeptidase M (a member of the H family) is bound to the membrane by a glycosylphosphatidylinositol anchor, unlike the majority of the M14 family, which are soluble. The zinc ligands have been determined as two histidines and a glutamate, and the catalytic residue has been identified as a C-terminal glutamate, but these do not form the characteristic metalloprotease HEXXH motif. Members of the carboxypeptidase A family are synthesised as inactive molecules with propeptides that must be cleaved to activate the enzyme. Structural studies of carboxypeptidases A and B reveal the propeptide to exist as a globular domain, followed by an extended alpha-helix; this shields the catalytic site, without specifically binding to it, while the substrate-binding site is blocked by making specific contacts. Other examples of protein families in this entry include: * Intron maturase * Putative mitochondrial processing peptidase alpha subunit * Superoxide dismutase [Mn] (EC 1.15.1.1) * Asparagine synthetase [glutamine-hydrolysing] 3 (EC 6.3.5.4) * Glucose-6-phosphate isomerase (EC 5.3.1.9) (en) |
| dbo:symbol |
Peptidase_M14 |
| dbo:wikiPageID |
29468225 (xsd:integer) |
| dbo:wikiPageLength |
4746 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
995178177 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Metalloproteinase dbr:C-terminal dbr:Enzyme_substrate_(biology) dbr:Alpha_helix dbc:Zinc_enzymes dbr:Carboxypeptidase_A dbr:Carboxypeptidase_E dbr:Glycosylphosphatidylinositol dbr:Residue_(chemistry) dbc:Protein_domains dbr:AGBL4 dbr:AGTPBP1_(gene) dbr:Catalysis dbr:CPA3 dbr:CPA4_(gene) dbr:CPA5 dbr:CPD_(gene) dbr:CPM_(gene) dbr:CPN1 dbr:CPXM1 dbr:CPZ_(gene) dbr:Propeptide dbr:Glutamate dbr:CPA1 dbr:CPA2 dbr:CPA6 dbr:CPB2 dbr:Carboxypeptidase_H dbr:AEBP1 dbr:CPXM2 dbr:AGBL1 dbr:AGBL2 dbr:AGBL3 dbr:AGBL5 dbr:CPB1 dbr:CPO_(gene) |
| dbp:cdd |
cd00596 (en) |
| dbp:interpro |
IPR000834 (en) |
| dbp:name |
Zinc carboxypeptidase (en) |
| dbp:pdb |
A:127-412 A:128-415 E:128-406 A:128-406 P:128-406 :128-406 D:128-406 A:128-406 A:128-406 B:128-406 D:128-406 :128-406 A:128-406 A:128-406 :128-406 :128-406 :128-406 A:128-406 P:128-406 :128-406 :128-406 A:128-406 B:128-406 :128-406 :128-406 A:128-406 :128-406 P:128-406 :128-406 B:129-408 A:127-404 A:127-404 C:125-404 A:125-404 A:125-404 :125-404 A:125-404 A:125-404 :113-402 A:28-303 A:16-291 (en) |
| dbp:pfam |
PF00246 (en) |
| dbp:prosite |
PDOC00123 (en) |
| dbp:scop |
1 (xsd:integer) |
| dbp:symbol |
Peptidase_M14 (en) |
| dbp:wikiPageUsesTemplate |
dbt:EC_number dbt:InterPro_content dbt:Reflist dbt:PDB3 dbt:Pfam_box |
| dct:subject |
dbc:Zinc_enzymes dbc:Protein_domains |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Activator114723079 yago:Attribute100024264 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Environment113934596 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:WikicatZincEnzymes dbo:Protein yago:Situation113927383 yago:Sphere114514039 yago:State100024720 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteinDomains |
| rdfs:comment |
The carboxypeptidase A family can be divided into two subfamilies: carboxypeptidase H (regulatory) and carboxypeptidase A (digestive). Members of the H family have longer C-termini than those of family A, and carboxypeptidase M (a member of the H family) is bound to the membrane by a glycosylphosphatidylinositol anchor, unlike the majority of the M14 family, which are soluble. Other examples of protein families in this entry include: (en) |
| rdfs:label |
Zinc carboxypeptidase (en) |
| owl:sameAs |
freebase:Zinc carboxypeptidase yago-res:Zinc carboxypeptidase wikidata:Zinc carboxypeptidase https://global.dbpedia.org/id/4xnwp |
| prov:wasDerivedFrom |
wikipedia-en:Zinc_carboxypeptidase?oldid=995178177&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:Zinc_carboxypeptidase |
| is dbo:wikiPageWikiLink of |
dbr:AGTPBP1_(gene) dbr:CPXM1 |
| is foaf:primaryTopic of |
wikipedia-en:Zinc_carboxypeptidase |