- Renaud, S. & de Lorgeril, M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 1523–1526 (1992).
Article CAS Google Scholar
- Joseph, J.A. et al. Reversals of age-related declines in neuronal signal transduction, cognitive, motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J. Neurosci. 19, 8114–8121 (1999).
Article CAS Google Scholar
- Seeram, N.P. et al. Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J. Agric. Food Chem. 52, 2512–2517 (2004).
Article CAS Google Scholar
- Hou, D.X. et al. Molecular mechanisms behind the chemopreventive effects of anthocyanidins. J. Biomed. Biotechnol. 5, 321–325 (2004).
Article Google Scholar
- Shin, W.H. et al. Protective effect of anthocyanins in middle cerebral artery occlusion and reperfusion model of cerebral ischemia in rats. Life Sci. 79, 130–137 (2006).
Article CAS Google Scholar
- Matsumoto, H. et al. Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin. J. Agric. Food Chem. 51, 3560–3563 (2003).
Article CAS Google Scholar
- Tsuda, T. et al. Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J. Nutr. 133, 2125–2130 (2003).
Article CAS Google Scholar
- Chun, O.K. et al. Superoxide radical scavenging activity of the major polyphenols in fresh plums. J. Agric. Food Chem. 51, 8067–8072 (2003).
Article CAS Google Scholar
- Meiers, S. et al. The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. J. Agric. Food Chem. 49, 958–962 (2001).
Article CAS Google Scholar
- Williams, R.J. et al. Flavonoids: antioxidants or signalling molecules? Free Radic. Biol. Med. 36, 838–849 (2004).
Article CAS Google Scholar
- Muir, S.R. et al. Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols. Nat. Biotechnol. 19, 470–474 (2001).
Article CAS Google Scholar
- Yeum, K.J. et al. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch. Biochem. Biophys. 430, 97–103 (2004).
Article CAS Google Scholar
- Sapir, M. et al. Molecular aspects of Anthocyanin fruit tomato in relation to high pigment-1. J. Hered. 99, 292–303 (2008).
Article CAS Google Scholar
- Davuluri, G.R. et al. Fruit-specific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes. Nat. Biotechnol. 23, 890–895 (2005).
Article CAS Google Scholar
- Broun, P. & Somerville, C. Progress in plant metabolic engineering. Proc. Natl. Acad. Sci. USA 98, 8925–8927 (2001).
Article CAS Google Scholar
- Martin, C. Transcription factors and the manipulation of plant trais. Curr. Opin. Biotechnol. 7, 130–138 (1996).
Article CAS Google Scholar
- Mathews, H. et al. Activation tagging in tomato identifies a transcriptional regulator of anthocyanin biosynthesis, modification, and transport. Plant Cell 15, 1689–1703 (2003).
Article CAS Google Scholar
- Bovy, A. et al. High-flavonol tomatoes resulting from the heterologous expression of the maize transcription factor genes Lc and C1. Plant Cell 14, 2509–2526 (2002).
Article CAS Google Scholar
- Martin, C. et al. Control of anthocyanin biosynthesis in flowers of Antirrhinum majus. Plant J. 1, 37–49 (1991).
Article CAS Google Scholar
- Schwinn, K. et al. A small family of MYB-regulatory genes controls floral pigmentation intensity and patterning in the genus Antirrhinum. Plant Cell 18, 831–851 (2006).
Article CAS Google Scholar
- Dooner, H.K. Coordinate genetic regulation of flavanoid biosynthetic enzyme in maize. Mol. Gen. Genet. 67, 345–355 (1983).
Google Scholar
- Quattrocchio, F. et al. Regulatory genes controlling anthocyanin pigmentation are functionally conserved among plant species and have distinct sets of target genes. Plant Cell 5, 1497–1512 (1993).
Article CAS Google Scholar
- Goodrich, J. et al. A common gene regulates pigmentation pattern in diverse plant species. Cell 68, 955–964 (1992).
Article CAS Google Scholar
- Kneissl, M.L. & Deikman, J. The tomato E8 gene influences ethylene biosynthesis in fruit but not in flowers. Plant Physiol. 112, 537–547 (1996).
Article CAS Google Scholar
- Donehower, L.A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356, 215–221 (1992).
Article CAS Google Scholar
- Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1–7 (1994).
Article CAS Google Scholar
- Sablina, A.A. et al. The antioxidant function of the p53 tumor suppressor. Nat. Med. 11, 1306–1313 (2005).
Article CAS Google Scholar
- Mooney, M. et al. Altered regulation of tomato and tobacco pigmentation genes caused by the delila gene of Antirrhinum. Plant J. 7, 333–339 (1995).
Article CAS Google Scholar
- Bate, N.J. et al. Quantitative relationship between phenylalanine ammonia-lyase levels and phenylpropanoid accumulation in transgenic tobacco identifies a rate-determining step in natural product synthesis. Proc. Natl. Acad. Sci. USA 91, 7608–7612 (1994).
Article CAS Google Scholar
- Prior, R.L. Fruits and vegetables in the prevention of cellular oxidative damage. Am. J. Clin. Nutr. 78 Suppl, 570S–578S (2003).
Article CAS Google Scholar
- Lotito, S.B. & Frei, B. Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic. Biol. Med. 41, 1727–1746 (2006).
Article CAS Google Scholar
- Toufektsian, M.C. et al. Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury. J. Nutr. 138, 747–752 (2008).
Article CAS Google Scholar
- Tsuda, T. Regulation of adipocyte function by anthocyanins; possibility of preventing the metabolic syndrome. J. Agric. Food Chem. 56, 642–646 (2008).
Article CAS Google Scholar
- Wightman, J.D. Red berries and their health benefits. Nutraceutical beverages: chemistry, nutrition, and health effects. in Nutraceutical Beverages: Chemistry, Nutrition, and Health Effects ACS Symp. ser. 871 (ed. Fereidoon, S.) 123–132, (American Chemical Society, Washington, DC, 2004).
Google Scholar