The impoverished gut—a triple burden of diarrhoea, stunting and chronic disease (original) (raw)

• Ravallioin, M., Chen, S. & Sangraula, P. Dollar a day revisited. Policy Research Working Paper No. 4620 (Washington DC, USA) (2008).
• The World Bank Poverty Overview. The World Bank [online], (2012).
• Kosek, M., Bern, C. & Guerrant, R. L. The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull. World Health Organ. 81, 197–204 (2003).
  PubMed PubMed Central Google Scholar
• Scrimshaw, N. S., Taylor, C. E. & Gordon, J. E. Interactions of nutrition and infection. Monogr. Ser. World Health Organ. 57, 3–329 (1968).
  CAS PubMed Google Scholar
• Mata Leonardo, J. (Ed.). The children of Santa Maria Cauque: a prospective field study of health and growth. (MIT Press, Cambridge, USA) (1978).
• Victora, C. G. et al. Maternal and child undernutrition: consequences for adult health and human capital. Lancet 371, 340–357 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Guerrant, R. L., Oria, R. B., Moore, S. R., Oria, M. O. & Lima, A. A. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr. Rev. 66, 487–505 (2008).
  Article PubMed Google Scholar
• Schorling, J. B. & Guerrant, R. L. Diarrhoea and catch-up growth. Lancet 335, 599–600 (1990).
  Article CAS PubMed Google Scholar
• Stoger, R. The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? Bioessays 30, 156–166 (2008).
  Article PubMed Google Scholar
• Gerson, C. D., Kent, T. H., Saha, J. R., Siddiqi, N. & Lindenbaum, J. Recovery of small-intestinal structure and function after residence in the tropics. II. Studies in Indians and Pakistanis living in New York City. Ann. Intern. Med. 75, 41–48 (1971).
  Article CAS PubMed Google Scholar
• Lindenbaum, J., Kent, T. H. & Sprinz, H. Malabsorption and jejunitis in American Peace Corps volunteers in Pakistan. Ann. Intern. Med. 65, 1201–1209 (1966).
  Article CAS PubMed Google Scholar
• Lindenbaum, J., Gerson, C. D. & Kent, T. H. Recovery of small-intestinal structure and function after residence in the tropics. I. Studies in Peace Corps volunteers. Ann. Intern. Med. 74, 218–222 (1971).
  Article CAS PubMed Google Scholar
• Goto, R., Mascie-Taylor, C. G. & Lunn, P. G. Impact of intestinal permeability, inflammation status and parasitic infections on infant growth faltering in rural Bangladesh. Br. J. Nutr. 101, 1509–1516 (2009).
  Article CAS PubMed Google Scholar
• Goto, R., Mascie-Taylor, C. G. & Lunn, P. G. Impact of anti-Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study. Trans. R. Soc. Trop. Med. Hyg. 103, 520–529 (2009).
  Article CAS PubMed Google Scholar
• Lunn, P. G., Northrop-Clewes, C. A. & Downes, R. M. Intestinal permeability, mucosal injury, and growth faltering in Gambian infants. Lancet 338, 907–910 (1991).
  Article CAS PubMed Google Scholar
• Lunn, P. G. Growth retardation and stunting of children in developing countries. Br. J. Nutr. 88, 109–110 (2002).
  Article CAS PubMed Google Scholar
• Humphrey, J. H. Child undernutrition, tropical enteropathy, toilets, and handwashing. Lancet 374, 1032–1035 (2009).
  Article PubMed Google Scholar
• Campbell, D. I., Elia, M. & Lunn, P. G. Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation. J. Nutr. 133, 1332–1338 (2003).
  Article CAS PubMed Google Scholar
• Costa, L. B. et al. Novel in vitro and in vivo models and potential new therapeutics to break the vicious cycle of cryptosporidium infection and malnutrition. J. Infect. Dis. 205, 1464–1471 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Coutinho, B. P. et al. Cryptosporidium infection causes undernutrition and, conversely, weanling undernutrition intensifies infection. J. Parasitol. 94, 1225–1232 (2008).
  Article CAS PubMed Google Scholar
• Roche, J. K., Cabel, A., Sevilleja, J., Nataro, J. & Guerrant, R. L. Enteroaggregative Escherichia coli (EAEC) impairs growth while malnutrition worsens EAEC infection: a novel murine model of the infection malnutrition cycle. J. Infect. Dis. 202, 506–514 (2010).
  Article PubMed Google Scholar
• Ueno, P. M. et al. Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G612–G622 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Checkley, W. et al. Multi-country analysis of the effects of diarrhoea on childhood stunting. Int. J. Epidemiol. 37, 816–830 (2008).
  Article PubMed PubMed Central Google Scholar
• Eppig, C., Fincher, C. L. & Thornhill, R. Parasite prevalence and the worldwide distribution of cognitive ability. Proc. Biol. Sci. 277, 3801–3808 (2010).
  Article PubMed PubMed Central Google Scholar
• Bhutta, Z. A. et al. What works? Interventions for maternal and child undernutrition and survival. Lancet 371, 417–440 (2008).
  Article PubMed Google Scholar
• Black, R. E. et al. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet 371, 243–260 (2008).
  Article PubMed Google Scholar
• Black, R. E. et al. Global, regional, and national causes of child mortality in 2008, a systematic analysis. Lancet 375, 1969–1987 (2010).
  Article PubMed Google Scholar
• Bryce, J., Boschi-Pinto, C., Shibuya, K. & Black, R. E. WHO estimates of the causes of death in children. Lancet 365, 1147–1152 (2005).
  Article PubMed Google Scholar
• Guerrant, R. L., Kosek, M., Lima, A. A., Lorntz, B. & Guyatt, H. L. Updating the DALYs for diarrhoeal disease. Trends Parasitol. 18, 191–193 (2002).
  Article PubMed Google Scholar
• Kosek, M. et al. Directing diarrhoeal disease research towards disease-burden reduction. J. Health Popul. Nutr. 27, 319–331 (2009).
  Article PubMed PubMed Central Google Scholar
• Lopez, A. D., Mathers, C. D., Ezzati, M., Jamison, D. T. & Murray, C. J. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367, 1747–1757 (2006).
  Article PubMed Google Scholar
• Murray, C. J. & Lopez, A. D. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 349, 1436–1442 (1997).
  Article CAS PubMed Google Scholar
• Mata, L. J., Kronmal, R. A., Urrutia, J. J. & Garcia, B. Antenatal events and postnatal growth and survival of children in a rural Guatemalan village. Ann. Hum. Biol. 3, 303–315 (1976).
  Article CAS PubMed Google Scholar
• Schlaudecker, E. P., Steinhoff, M. C. & Moore, S. R. Interactions of diarrhea, pneumonia, and malnutrition in childhood: recent evidence from developing countries. Curr. Opin. Infect. Dis. 24, 496–502 (2011).
  Article PubMed PubMed Central Google Scholar
• Shrimpton, R., Victora C. G., de, O. M., Lima, R. C., Blossner, M. & Clugston, G. Worldwide timing of growth faltering: implications for nutritional interventions. Pediatrics 107, E75 (2001).
  Article CAS PubMed Google Scholar
• Victora C. G., de, O. M., Hallal, P. C., Blossner, M. & Shrimpton, R. Worldwide timing of growth faltering: revisiting implications for interventions. Pediatrics 125, e473–e480 (2010).
  Article PubMed Google Scholar
• Black, R. E., Brown, K. H. & Becker, S. Effects of diarrhea associated with specific enteropathogens on the growth of children in rural Bangladesh. Pediatrics 73, 799–805 (1984).
  CAS PubMed Google Scholar
• Guerrant, R. L. et al. Prospective study of diarrheal illnesses in northeastern Brazil: patterns of disease, nutritional impact, etiologies, and risk factors. J. Infect. Dis. 148, 986–997 (1983).
  Article CAS PubMed Google Scholar
• Lima, A. A. et al. Persistent diarrhea signals a critical period of increased diarrhea burdens and nutritional shortfalls: a prospective cohort study among children in northeastern Brazil. J. Infect. Dis. 181, 1643–1651 (2000).
  Article CAS PubMed Google Scholar
• Moore, S. R. et al. Early childhood diarrhoea and helminthiases associate with long-term linear growth faltering. Int. J. Epidemiol. 30, 1457–1464 (2001).
  Article CAS PubMed Google Scholar
• Moore, S. R., Lima, A. A. & Guerrant, R. L. Infection: Preventing 5 million child deaths from diarrhea in the next 5 years. Nat. Rev. Gastroenterol. Hepatol. 8, 363–364 (2011).
  Article PubMed Google Scholar
• Guerrant, R. L., Schorling, J. B., McAuliffe J. F. & de Souza, M. A. Diarrhea as a cause and an effect of malnutrition: diarrhea prevents catch-up growth and malnutrition increases diarrhea frequency and duration. Am. J. Trop. Med. Hyg. 47, 28–35 (1992).
  Article CAS PubMed Google Scholar
• Mata, L. Diarrheal disease as a cause of malnutrition. Am. J. Trop. Med. Hyg. 47, 16–27 (1992).
  Article CAS PubMed Google Scholar
• Schorling, J. B., McAuliffe, J. F., de Souza, M. A. & Guerrant, R. L. Malnutrition is associated with increased diarrhoea incidence and duration among children in an urban Brazilian slum. Int. J. Epidemiol. 19, 728–735 (1990).
  Article CAS PubMed Google Scholar
• Costa, L. B. et al. _Cryptosporidium_-malnutrition interactions: mucosal disruption, cytokines, and TLR signaling in a weaned murine model. J. Parasitol. 97, 1113–1120 (2011).
  Article CAS PubMed Google Scholar
• Fischer Walker, C. L. et al. Does childhood diarrhea influence cognition beyond the diarrhea-stunting pathway? PLoS ONE 7, e7908 (2012).
  Google Scholar
• Adair, L. S. et al. Cohort profile: the Cebu longitudinal health and nutrition survey. Int. J. Epidemiol. 40, 619–625 (2011).
  Article PubMed Google Scholar
• Berkman, D. S., Lescano, A. G., Gilman, R. H., Lopez, S. L. & Black, M. M. Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study. Lancet 359, 564–571 (2002).
  Article PubMed Google Scholar
• Chang, S. M., Walker, S. P., Grantham-McGregor, S. & Powell, C. A. Early childhood stunting and later behaviour and school achievement. J. Child. Psychol. Psychiatry 43, 775–783 (2002).
  Article CAS PubMed Google Scholar
• Cusick, S. E. & Georgieff, M. K. Nutrient supplementation and neurodevelopment: timing is the key. Arch. Pediatr. Adolesc. Med. 166, 481–482 (2012).
  Article PubMed Google Scholar
• Martorell, R., Habicht, J. P. & Rivera, J. A. History and design of the INCAP longitudinal study (1969–77) and its follow-up (1988–1989). J. Nutr. 125 (Suppl.), 1027S–1041S (1995).
  CAS PubMed Google Scholar
• Mendez, M. A. & Adair, L. S. Severity and timing of stunting in the first two years of life affect performance on cognitive tests in late childhood. J. Nutr. 129, 1555–1562 (1999).
  Article CAS PubMed Google Scholar
• Niehaus, M. D. et al. Early childhood diarrhea is associated with diminished cognitive function 4 to 7 years later in children in a northeast Brazilian shantytown. Am. J. Trop. Med. Hyg. 66, 590–593 (2002).
  Article PubMed Google Scholar
• Patrick, P. D. et al. Limitations in verbal fluency following heavy burdens of early childhood diarrhea in Brazilian shantytown children. Child. Neuropsychol. 11, 233–244 (2005).
  Article PubMed Google Scholar
• Pollitt, E., Gorman, K. S., Engle, P. L., Martorell, R. & Rivera, J. Early supplementary feeding and cognition: effects over two decades. Monogr. Soc. Res. Child. Dev. 58, 1–99 (1993).
  Article CAS PubMed Google Scholar
• Pongcharoen, T. et al. Influence of prenatal and postnatal growth on intellectual functioning in school-aged children. Arch. Pediatr. Adolesc. Med. 166, 411–416 (2012).
  Article PubMed Google Scholar
• Popkin, B. M. et al. Breast-feeding and diarrheal morbidity. Pediatrics 86, 874–882 (1990).
  CAS PubMed Google Scholar
• Tarleton, J. L. et al. Cognitive effects of diarrhea, malnutrition, and Entamoeba histolytica infection on school age children in Dhaka, Bangladesh. Am. J. Trop. Med. Hyg. 74, 475–481 (2006).
  Article PubMed Google Scholar
• Walker, S. P., Grantham-McGregor, S. M., Powell, C. A. & Chang, S. M. Effects of growth restriction in early childhood on growth, IQ, and cognition at age 11 to 12 years and the benefits of nutritional supplementation and psychosocial stimulation. J. Pediatr. 137, 36–41 (2000).
  Article CAS PubMed Google Scholar
• Hoddinott, J., Maluccio, J. A., Behrman, J. R., Flores, R. & Martorell, R. Effect of a nutrition intervention during early childhood on economic productivity in Guatemalan adults. Lancet 371, 411–416 (2008).
  Article PubMed Google Scholar
• Stein, A. D. et al. Nutritional supplementation in early childhood, schooling, and intellectual functioning in adulthood: a prospective study in Guatemala. Arch. Pediatr. Adolesc. Med. 162, 612–618 (2008).
  Article PubMed PubMed Central Google Scholar
• Ajjampur, S. S. et al. Effect of cryptosporidial and giardial diarrhoea on social maturity, intelligence and physical growth in children in a semi-urban slum in south India. Ann. Trop. Paediatr. 31, 205–212 (2011).
  Article CAS PubMed Google Scholar
• Guerrant, D. I. et al. Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and cognitive function four-seven years later in a poor urban community in northeast Brazil. Am. J. Trop. Med. Hyg. 61, 707–713 (1999).
  Article CAS PubMed Google Scholar
• Nokes, C., Grantham-McGregor, S. M., Sawyer, A. W., Cooper, E. S. & Bundy, D. A. Parasitic helminth infection and cognitive function in school children. Proc. Biol. Sci. 247, 77–81 (1992).
  Article CAS PubMed Google Scholar
• Partovi, F., Khalili, G., Kariminia, A. & Mahmoudzadeh-Niknam, H. Effect of Giardia lamblia infection on the cognitive function of school children. Iranian J. Publ. Health 36, 73–78 (2007).
  Google Scholar
• Petri, W. A. Jr et al. Enteric infections, diarrhea, and their impact on function and development. J. Clin. Invest. 118, 1277–1290 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Fischer Walker, C. L. et al. Does childhood diarrhea influence cognition beyond the diarrhea-stunting pathway? PLoS ONE 7, e47908 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Misra, A. & Khurana, L. Obesity and the metabolic syndrome in developing countries. J. Clin. Endocrinol. Metab. 93 (Suppl. 1), S9–S30 (2008).
  Article CAS PubMed Google Scholar
• Yach, D., Hawkes, C., Gould, C. L. & Hofman, K. J. The global burden of chronic diseases: overcoming impediments to prevention and control. JAMA 291, 2616–2622 (2004).
  Article CAS PubMed Google Scholar
• Godfrey, K. M., Gluckman, P. D. & Hanson, M. A. Developmental origins of metabolic disease: life course and intergenerational perspectives. Trends Endocrinol. Metab. 21, 199–205 (2010).
  Article CAS PubMed Google Scholar
• Barker, D. J. Fetal programming of coronary heart disease. Trends Endocrinol. Metab. 13, 364–368 (2002).
  Article CAS PubMed Google Scholar
• Barker, D. J. et al. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36, 62–67 (1993).
  Article CAS PubMed Google Scholar
• Barker, D. J., Osmond, C., Golding, J., Kuh, D. & Wadsworth, M. E. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 298, 564–567 (1989).
  Article CAS PubMed PubMed Central Google Scholar
• Heijmans, B. T. et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc. Natl Acad. Sci. USA 105, 17046–17049 (2008).
  Article PubMed PubMed Central Google Scholar
• Veening, M. A., Van Weissenbruch, M. M. & Delemarre-Van De Waal, H. A. Glucose tolerance, insulin sensitivity, and insulin secretion in children born small for gestational age. J. Clin. Endocrinol. Metab. 87, 4657–4661 (2002).
  Article CAS PubMed Google Scholar
• Williams, S., St. George, I. M. & Silva, P. A. Intrauterine growth retardation and blood pressure at age seven and eighteen. J. Clin. Epidemiol. 45, 1257–1263 (1992).
  Article CAS PubMed Google Scholar
• Ravelli, G. P., Stein, Z. A. & Susser, M. W. Obesity in young men after famine exposure in utero and early infancy. N. Engl. J. Med. 295, 349–353 (1976).
  Article CAS PubMed Google Scholar
• Roseboom T. J. et al. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Mol. Cell Endocrinol. 185, 93–98 (2001).
  Article CAS PubMed Google Scholar
• Nilsson, P. M. Elevated blood pressure predicts type 2 diabetes, but why? J. Hypertens. 26, 1740–1741 (2008).
  Article CAS PubMed Google Scholar
• Tobi, E. W. et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum. Mol. Genet. 18, 4046–4053 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Barker, D. J., Osmond, C., Forsen, T. J., Kajantie, E. & Eriksson, J. G. Trajectories of growth among children who have coronary events as adults. N. Engl. J. Med. 353, 1802–1809 (2005).
  Article CAS PubMed Google Scholar
• Bhargava, S. K. et al. Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N. Engl. J. Med. 350, 865–875 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Deboer, M. D. et al. Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome? Nutr. Rev. 70, 642–653 (2012).
  Article PubMed Google Scholar
• Ferreira, H. S. et al. Short stature of mothers from an area endemic for undernutrition is associated with obesity, hypertension and stunted children: a population-based study in the semi-arid region of Alagoas, Northeast Brazil. Br. J. Nutr. 101, 1239–1245 (2009).
  Article CAS PubMed Google Scholar
• Florencio, T. T., Ferreira, H. S., Cavalcante, J. C., Stux, G. R. & Sawaya, A. L. Short stature, abdominal obesity, insulin resistance and alterations in lipid profile in very low-income women living in Maceio, north-eastern Brazil. Eur. J. Cardiovasc. Prev. Rehabil. 14, 346–348 (2007).
  Article PubMed Google Scholar
• Florencio, T. T., Ferreira, H. S., Cavalcante, J. C. & Sawaya, A. L. Short stature, obesity and arterial hypertension in a very low income population in North-eastern Brazil. Nutr. Metab. Cardiovasc. Dis. 14, 26–33 (2004).
  Article CAS PubMed Google Scholar
• Schroeder, D. G., Martorell, R. & Flores, R. Infant and child growth and fatness and fat distribution in Guatemalan adults. Am. J. Epidemiol. 149, 177–185 (1999).
  Article CAS PubMed Google Scholar
• Sesso, R., Barreto, G. P., Neves, J. & Sawaya, A. L. Malnutrition is associated with increased blood pressure in childhood. Nephron Clin. Pract. 97, c61–c66 (2004).
  Article PubMed Google Scholar
• Grillol, L. P. et al. Lower resting metabolic rate and higher velocity of weight gain in a prospective study of stunted vs nonstunted girls living in the shantytowns of Sao Paulo, Brazil. Eur. J. Clin. Nutr. 59, 835–842 (2005).
  Article CAS PubMed Google Scholar
• Walker, S. P., Chang, S. M. & Powell, C. A. The association between early childhood stunting and weight status in late adolescence. Int. J. Obes. 31, 347–352 (2007).
  Article CAS Google Scholar
• Timaeus, I. M. Stunting and obesity in childhood: a reassessment using longitudinal data from South Africa. Int. J. Epidemiol. 41, 764–772 (2012).
  Article PubMed Google Scholar
• Martins, V. J., Martins, P. A., Neves, J. & Sawaya, A. L. Children recovered from malnutrition exhibit normal insulin production and sensitivity. Br. J. Nutr. 99, 297–302 (2008).
  Article CAS PubMed Google Scholar
• Fall, C. H. et al. Adult metabolic syndrome and impaired glucose tolerance are associated with different patterns of BMI gain during infancy: Data from the New Delhi Birth Cohort. Diabetes Care 31, 2349–2356 (2008).
  Article PubMed PubMed Central Google Scholar
• Margolis, R. Childhood Morbidity and Health in Early Adulthood: life course linkages in a high morbidity context. Adv. Life Course Res. 15, 132–146 (2010).
  Article PubMed PubMed Central Google Scholar
• Margolis, R. The effects of early childhood diseases on young adult health in Guatemala. University of Pennsylvania _Scholarly_Commons: Repository [online], (2008).
• Brenchley, J. M. & Douek, D. C. Microbial translocation across the GI tract. Annu. Rev. Immunol. 30, 149–173 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Jiang, W. et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J. Infect. Dis. 199, 1177–1185 (2009).
  Article CAS PubMed Google Scholar
• Moore, S. R. et al. Prolonged episodes of acute diarrhea reduce growth and increase risk of persistent diarrhea in children. Gastroenterology 139, 1156–1164 (2010).
  Article PubMed Google Scholar
• Camilleri, M. et al. Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion. Neurogastroenterol. Motil. 22, e15–e26 (2010).
  Article CAS PubMed Google Scholar
• Lima, A. A. et al. Intestinal barrier function and weight gain in malnourished children taking glutamine supplemented enteral formula. J. Pediatr. Gastroenterol. Nutr. 40, 28–35 (2005).
  Article CAS PubMed Google Scholar
• Barboza Junior, M. S., Silva, T. M., Guerrant, R. L. & Lima, A. A. Measurement of intestinal permeability using mannitol and lactulose in children with diarrheal diseases. Braz. J. Med. Biol. Res. 32, 1499–1504 (1999).
  Article CAS PubMed Google Scholar
• Rahaman, M. M. & Wahed, M. A. in Diarrhea and Malnutrition: Interactions, Mechanisms and Interventions. (eds Chen, L. C. & Sears, C. L.) 155–160 (Plenum Press, New York and London, 1983).
  Book Google Scholar
• Steiner, T. S., Lima, A. A., Nataro, J. P. & Guerrant, R. L. Enteroaggregative Escherichia coli produce intestinal inflammation and growth impairment and cause interleukin-8 release from intestinal epithelial cells. J. Infect. Dis. 177, 88–96 (1998).
  Article CAS PubMed Google Scholar
• Peterson, K. M. et al. The expression of REG 1A and REG 1B is increased during acute amebic colitis. Parasitol. Int. 60, 296–300 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Sandler, N. G. et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J. Infect. Dis. 203, 780–790 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Swann, J. R. et al. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc. Natl Acad. Sci. USA 108 (Suppl. 1), 4523–4530 (2011).
  Article PubMed Google Scholar
• Saric, J. et al. Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents. J. Proteome Res. 9, 2255–2264 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Masoodi, I. et al. Fecal lactoferrin, myeloperoxidase and serum C-reactive are effective biomarkers in the assessment of disease activity and severity in patients with idiopathic ulcerative colitis. J. Gastroenterol. Hepatol. 24, 1768–1774 (2009).
  Article CAS PubMed Google Scholar
• Campbell, D. I., McPhail, G., Lunn, P. G., Elia, M. & Jeffries, D. J. Intestinal inflammation measured by fecal neopterin in Gambian children with enteropathy: association with growth failure, Giardia lamblia, and intestinal permeability. J. Pediatr. Gastroenterol. Nutr. 39, 153–157 (2004).
  Article PubMed Google Scholar
• Langhorst, J. et al. Comparison of 4 neutrophil-derived proteins in feces as indicators of disease activity in ulcerative colitis. Inflamm. Bowel Dis. 11, 1085–1091 (2005).
  Article PubMed Google Scholar
• Reigstad, C. S., Lunden, G. O., Felin, J. & Backhed, F. Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota. PLoS ONE 4, e5842 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Fasano, A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin. Gastroenterol. Hepatol. 10, 1096–1100 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Tripathi, A. et al. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc. Natl Acad. Sci. USA 106, 16799–16804 (2009).
  Article PubMed PubMed Central Google Scholar
• George, N. S., Sankineni, A. & Parkman, H. P. Small intestinal bacterial overgrowth in gastroparesis. Dig. Dis. Sci. http://doi:10.1007/s10620-012-2426-7.
• Esposito, I. et al. Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease: an observation on non-absorbable antibiotics. World J. Gastroenterol. 13, 6016–6021 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Papadia, C. et al. Plasma citrulline as a quantitative biomarker of HIV-associated villous atrophy in a tropical enteropathy population. Clin. Nutr. 29, 795–800 (2010).
  Article CAS PubMed Google Scholar
• Lima, N. L. et al. Wasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formula. J. Pediatr. Gastroenterol. Nutr. 44, 365–374 (2007).
  Article CAS PubMed Google Scholar
• Stephenson, L. S., Latham, M. C., Kurz, K. M., Kinoti, S. N. & Brigham, H. Treatment with a single dose of albendazole improves growth of Kenyan schoolchildren with hookworm, Trichuris trichiura, and Ascaris lumbricoides infections. Am. J. Trop. Med. Hyg. 41, 78–87 (1989).
  Article CAS PubMed Google Scholar
• Wardlaw, T., Salama, P., Brocklehurst, C. & Mason, E. Diarrhoea: why children are still dying and what can be done. Lancet 13, 870–872 (2010).
  Article Google Scholar
• Moore, S. R. Update on prolonged and persistent diarrhea in children. Curr. Opin. Gastroenterol. 27, 19–23 (2011).
  Article CAS PubMed Google Scholar
• Ladd, F. V. et al. Zinc and glutamine improve brain development in suckling mice subjected to early postnatal malnutrition. Nutrition 26, 662–670 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Mitter, S. S. et al. Apolipoprotein E4 influences growth and cognitive responses to micronutrient supplementation in shantytown children from northeast Brazil. Clinics (Sao Paulo) 67, 11–18 (2012).
  Article Google Scholar
• Taniuchi, M. et al. Development of a multiplex polymerase chain reaction assay for diarrheagenic Escherichia coli and Shigella spp. and its evaluation on colonies, culture broths, and stool. Diagn. Microbiol. Infect. Dis. 73, 121–128 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Platts-Mills, J. A., Operario, D. J. & Houpt, E. R. Molecular diagnosis of diarrhea: current status and future potential. Curr. Infect. Dis. Rep. 14, 41–46 (2012).
  Article PubMed Google Scholar
• Stroup, S. et al. Dual probe DNA capture for sensitive real-time PCR detection of Cryptosporidium and Giardia. Mol. Cell Probes 26, 104–106 (2012).
  Article CAS PubMed Google Scholar
• Oberhelman, R. A. et al. A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children. J. Pediatr. 134, 15–20 (1999).
  Article CAS PubMed Google Scholar
• Preidis, G. A. et al. Probiotics, enteric and diarrheal diseases, and global health. Gastroenterology 140, 8–14 (2011).
  Article PubMed Google Scholar
• Guandalini, S. Probiotics for prevention and treatment of diarrhea. J. Clin. Gastroenterol. 45 (Suppl.), S149–S153 (2011).
  Article PubMed Google Scholar
• Videlock, E. J. & Cremonini, F. Meta-analysis: probiotics in antibiotic-associated diarrhoea. Aliment. Pharmacol. Ther. 35, 1355–1369 (2012).
  Article CAS PubMed Google Scholar
• Passaro, D. J. et al. Acute Helicobacter pylori infection is followed by an increase in diarrheal disease among Peruvian children. Pediatrics 108, E87 (2001).
  Article CAS PubMed Google Scholar
• Shmuely, H. et al. Association of Helicobacter pylori infection with Shigella gastroenteritis in young children. Am. J. Gastroenterol. 99, 2041–2045 (2004).
  Article PubMed Google Scholar
• Cohen, D., Shoham, O., Orr, N. & Muhsen, K. An inverse and independent association between Helicobacter pylori infection and the incidence of shigellosis and other diarrheal diseases. Clin. Infect. Dis. 54, e35–e42 (2012).
  Article CAS PubMed Google Scholar
• Serazin, A. C., Shackelton, L. A., Wilson, C. & Bhan, M. K. Improving the performance of enteric vaccines in the developing world. Nat. Immunol. 11, 769–773 (2010).
  Article CAS PubMed Google Scholar