Marked improvement of severe progressive systemic sclerosis after transplantation of mesenchymal stem cells from an allogeneic haploidentical-related donor mediated by ligation of CD137L (original) (raw)

Leukemia volume 22, pages 1062–1064 (2008)Cite this article

Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by activation of the immune system, by vasculopathy due to a dysfunction of endothelial cells and by the excessive deposition of collagen in the skin and various internal organs. Prognosis is poor in individuals presenting with diffuse cutaneous, lung or renal involvement. As of now, there is no effective treatment for the disease and SSc is generally regarded as refractory to conventional immunosuppression.

Mesenchymal stem cells (MSCs) possess immunosuppressive capacities in an allogeneic host. This has been successfully utilized in the treatment of steroid refractory acute graft versus host (aGVH),1 a condition sharing similarities with SSc. To date, only data from animal studies suggest an activity of mammalian MSCs against autoimmune diseases in vivo.2

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References

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Author notes

  1. M Christopeit and M Schendel: Authors contributed equally to this work.

Authors and Affiliations

  1. Department of Internal Medicine IV—Oncology and Hematology, Bone Marrow Transplantation Unit, University Hospital Halle, Ernst-Grube-Strasse 40, Halle, Germany
    M Christopeit, L P Müller & G Behre
  2. Department of Internal Medicine I—Gastroenterology and Rheumatology—University Hospital Halle, Ernst-Grube-Strasse 40, Halle, Germany
    M Schendel & G Keysser
  3. Department of Pediatrics, University Hospital Halle, Ernst-Grube-Strasse 40, Halle, Germany
    J Föll

Authors

  1. M Christopeit
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  2. M Schendel
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  3. J Föll
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  4. L P Müller
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  5. G Keysser
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  6. G Behre
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Corresponding author

Correspondence toG Behre.

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Christopeit, M., Schendel, M., Föll, J. et al. Marked improvement of severe progressive systemic sclerosis after transplantation of mesenchymal stem cells from an allogeneic haploidentical-related donor mediated by ligation of CD137L.Leukemia 22, 1062–1064 (2008). https://doi.org/10.1038/sj.leu.2404996

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