Acridone synthase (original) (raw)

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Class of enzymes

In enzymology, an acridone synthase (EC 2.3.1.159) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + N-methylanthraniloyl-CoA ⇌ {\displaystyle \rightleftharpoons } 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2

Thus, the two substrates of this enzyme are malonyl-CoA and N-methylanthraniloyl-CoA, whereas its 3 products are CoA, 1,3-dihydroxy-N-methylacridone, and CO2.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing). This enzyme participates in acridone alkaloid biosynthesis.

• Baumert A, Maier W, Gröger D, Deutzmann R (1994). "Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L". Z. Naturforsch. C. 49 (1–2): 26–32. PMID 8148006.
• Maier W, Baumert A, Schumann B, Furukawa H, Gröger D (1993). "Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures". Phytochemistry. 32 (3): 691–698. doi:10.1016/S0031-9422(00)95155-0.
• Matern U; Springob, K; Urbanke, C; Ernwein, C; Schröder, G; Schröder, J; Matern, U (1999). "Native acridone synthases I and II from Ruta graveolens L. form homodimers". FEBS Lett. 448 (1): 135–40. doi:10.1016/S0014-5793(99)00355-5. PMID 10217426.
• Junghanns KT, Kneusel RE, Gröger D, Matern U (1998). "Differential regulation and distribution of acridone synthase in Ruta graveolens". Phytochemistry. 49 (2): 403–11. doi:10.1016/S0031-9422(98)00104-6. PMID 9747538.