Bioterrorism (original) (raw)

Terrorism involving biological agents

Firefighters triage victims of a simulated bioterrorism attack at the Armed Forces Reserve Center during the Portland Area Capabilities Exercise (PACE) Setter at Camp Withycombe in Clackamas, Oregon, May 22, 2013. The purpose of the PACE Setter exercise is to test regional and interagency response to public health incidents affecting multiple agencies. (Photo by Staff Sgt. April Davis, Oregon Military Department Public Affairs)

United States airman wearing an M17 nuclear, biological, and chemical warfare mask and hood

Bioterrorism is terrorism involving the intentional release or dissemination of biological agents.[1] These agents include bacteria, viruses, insects, fungi, and/or their toxins, and may be in a naturally occurring or a human-modified form, in much the same way as in biological warfare.[2][1] Further, modern agribusiness is vulnerable to anti-agricultural attacks by terrorists, and such attacks can seriously damage economy as well as consumer confidence.[3] The latter destructive activity is called agrobioterrorism and is a subtype of agro-terrorism.[4]

Definition Source
"Bioterrorism is the deliberate release of viruses, bacteria, toxins or other harmful agents to cause illness or death in people, animals or plants." Interpol[2]
"A biological attack, or bioterrorism, is the intentional release of viruses, bacteria, or other germs that can sicken or kill people, livestock, or crops." CDC[5]
"Violent action using living matter, such as bacteria, to harm or kill people for political reasons" Cambridge Dictionary[6]

Bioterrorism agents are typically found in nature, but could be mutated or altered to increase their ability to cause disease, make them resistant to current medicines, or to increase their ability to be spread into the environment. Biological agents can be spread through the air, water, or in food. Biological agents are attractive to terrorists because they are extremely difficult to detect and do not cause illness for several hours to several days. Some bioterrorism agents, like the smallpox virus, can be spread from person to person and some, like anthrax, cannot.[7][8]

Bioterrorism may be favored because biological agents are relatively easy and inexpensive to obtain, can be easily disseminated, and can cause widespread fear and panic beyond the actual physical damage.[9] Military leaders, however, have learned that, as a military asset, bioterrorism has some important limitations; it is difficult to use a bioweapon in a way that only affects the enemy and not friendly forces. A biological weapon is useful to terrorists mainly as a method of creating mass panic and disruption to a state or a country. However, technologists such as Bill Joy have warned of the potential power which genetic engineering might place in the hands of future bio-terrorists.[10]

The use of agents that do not cause harm to humans, but disrupt the economy, have also been discussed.[11] One such pathogen is the foot-and-mouth disease (FMD) virus, which is capable of causing widespread economic damage and public concern (as witnessed in the 2001 and 2007 FMD outbreaks in the UK), while having almost no capacity to infect humans.

By the time World War I began, attempts to use anthrax were directed at animal populations. This generally proved to be ineffective.

Shortly after the start of World War I, Germany launched a biological sabotage campaign in the United States, Russia, Romania, and France.[12] At that time, Anton Dilger lived in Germany, but in 1915 he was sent to the United States carrying cultures of glanders, a virulent disease of horses and mules. Dilger set up a laboratory in his home in Chevy Chase, Maryland. He used stevedores working the docks in Baltimore to infect horses with glanders while they were waiting to be shipped to Britain. Dilger was under suspicion as being a German agent, but was never arrested. Dilger eventually fled to Madrid, Spain, where he died during the Influenza Pandemic of 1918.[13] In 1916, the Russians arrested a German agent with similar intentions. Germany and its allies infected French cavalry horses and many of Russia's mules and horses on the Eastern Front. These actions hindered artillery and troop movements, as well as supply convoys.[12]

In 1972, police in Chicago arrested two college students, Allen Schwander and Stephen Pera, who had planned to poison the city's water supply with typhoid and other bacteria. Schwander had founded a terrorist group, "R.I.S.E.", while Pera collected and grew cultures from the hospital where he worked. The two men fled to Cuba after being released on bail. Schwander died of natural causes in 1974, while Pera returned to the U.S. in 1975 and was put on probation.[14]

In 1979, anthrax spores killed around 66 people after the spores were unintentionally released from a military lab near Sverdlovsk, Russia. This occurrence of inhalational anthrax had provided a majority of the knowledge scientists understand about clinical anthrax. Soviet officials and physicians claimed the epidemic was produced by the consumption of infected game meat, but further investigation proves the source of infection were the inhaled spores. There is continued discussion about the intentionality of the epidemic and some speculate it was calculated by the Soviet government.[15]

In 1980, the World Health Organization (WHO) announced the eradication of smallpox, a highly contagious and incurable disease. Although the disease has been eliminated in the wild, frozen stocks of smallpox virus are still maintained by the governments of the United States and Russia. Disastrous consequences are feared if rogue politicians or terrorists were to get hold of the smallpox strains.[16] Since vaccination programs are now terminated, the world population is more susceptible to smallpox than ever before.

In Oregon in 1984, followers of the Bhagwan Shree Rajneesh attempted to control a local election by incapacitating the local population. They infected salad bars in 11 restaurants, produce in grocery stores, doorknobs, and other public domains with Salmonella typhimurium bacteria in the city of The Dalles, Oregon. The attack infected 751 people with severe food poisoning. There were no fatalities. This incident was the first known bioterrorist attack in the United States in the 20th century.[17] It was also the single largest bioterrorism attack on U.S. soil.[18]

In June 1993, the religious group Aum Shinrikyo released anthrax in Tokyo. Eyewitnesses reported a foul odor. The attack was a failure, because it did not infect a single person. The reason for this is due to the fact that the group used the vaccine strain of the bacterium. The spores which were recovered from the site of the attack showed that they were identical to an anthrax vaccine strain that was given to animals at the time. These vaccine strains are missing the genes that cause a symptomatic response.[19]

In September and October 2001, several cases of anthrax broke out in the United States, apparently deliberately caused. Letters laced with infectious anthrax were concurrently delivered to news media offices and the U.S. Congress, alongside an ambiguously related case in Chile. The letters killed five people.[20]

There are multiple considerable scenarios, how terrorists might employ biological agents.[3] In 2000, tests conducted by various US agencies showed that indoor attacks in densely populated spaces are much more serious than outdoor attacks. Such enclosed spaces are large buildings, trains, indoor arenas, theaters, malls, tunnels and similar. Contra-measures against such scenarios are building architecture and ventilation systems engineering. In 1993, sewage was spilled out into a river, subsequently drawn into the water system and affected 400,000 people in Milwaukee, Wisconsin.[21] The disease-causing organism was cryptosporidium parvum. This man-made disaster can be a template for a terrorist scenario.[3] Nevertheless, terrorist scenarios are considered more likely near the points of delivery than at the water sources before the water treatment.[3] Release of biological agents is more likely for a single building or a neighborhood. Counter-measures against this scenario include the further limitation of access to the water supply systems, tunnels, and infrastructure. Agricultural crop-duster flights might be misused as delivery devices for biological agents as well.[3] Counter-measures against this scenario are background checks of employees of crop-dusting companies and surveillance procedures.

In the most common hoax scenario, no biological agents are employed.[22] For instance, an envelope with powder in it that says, “You've just been exposed to anthrax.” Such hoaxes have been shown to have a large psychological impact on the population.[23]

Anti-agriculture attacks are considered to require relatively little expertise and technology.[23] Biological agents that attack livestock, fish, vegetation, and crops are mostly not contagious to humans and are therefore easier for attackers to handle. Even a few cases of infection can disrupt a country's agricultural production and exports for months, as evidenced by FMD outbreaks.

Under current United States law, bio-agents which have been declared by the U.S. Department of Health and Human Services or the U.S. Department of Agriculture to have the "potential to pose a severe threat to public health and safety" are officially defined as "select agents." The CDC categorizes these agents (A, B or C) and administers the Select Agent Program, which regulates the laboratories which may possess, use, or transfer select agents within the United States. As with US attempts to categorize harmful recreational drugs, designer viruses are not yet categorized and avian H5N1 has been shown to achieve high mortality and human-communication in a laboratory setting.

These high-priority agents pose a risk to national security, can be easily transmitted and disseminated, result in high mortality, have potential major public health impact, may cause public panic, or require special action for public health preparedness.

Category B agents are moderately easy to disseminate and have low mortality rates.

Category C agents are emerging pathogens that might be engineered for mass dissemination because of their availability, ease of production and dissemination, high mortality rate, or ability to cause a major health impact.

Planning and monitoring

[edit]

Planning may involve the development of biological identification systems. Until recently in the United States, most biological defense strategies have been geared to protecting soldiers on the battlefield rather than ordinary people in cities. Financial cutbacks have limited the tracking of disease outbreaks. Some outbreaks, such as food poisoning due to E. coli or Salmonella, could be of either natural or deliberate origin.

Global defense strategies have also been put into place including the introduction of the Biological and Toxin Weapons Convention in 1975. A majority of countries across the globe participated in the conventions (144) but a handful chose not to take part in the defense. Many of the countries who opted out of the convention are located in the Middle East and former Soviet Union countries.[54]

Export controls on biological agents are not applied uniformly, providing terrorists a route for acquisition.[55] Laboratories are working on advanced detection systems to provide early warning, identify contaminated areas and populations at risk, and to facilitate prompt treatment.[56] Methods for predicting the use of biological agents in urban areas as well as assessing the area for the hazards associated with a biological attack are being established in major cities. In addition, forensic technologies are working on identifying biological agents, their geographical origins and/or their initial source. Efforts include decontamination technologies to restore facilities without causing additional environmental concerns.

Early detection and rapid response to bioterrorism depend on close cooperation between public health authorities and law enforcement; however, such cooperation is lacking. National detection assets and vaccine stockpiles are not useful if local and state officials do not have access to them.[57]

Aspects of protection against bioterrorism in the United States include:

On a CNN news broadcast in 2011, the CNN chief medical correspondent, Dr. Sanjay Gupta, weighed in on the American government's recent approach to bioterrorist threats. He explains how, even though the United States would be better fending off bioterrorist attacks now than they would be a decade ago, the amount of money available to fight bioterrorism over the last three years has begun to decrease. Looking at a detailed report that examined the funding decrease for bioterrorism in fifty-one American cities, Dr. Gupta stated that the cities "wouldn't be able to distribute vaccines as well" and "wouldn't be able to track viruses." He also said that film portrayals of global pandemics, such as Contagion, were actually quite possible and may occur in the United States under the right conditions.[65]

A news broadcast by MSNBC in 2010 also stressed the low levels of bioterrorism preparedness in the United States. The broadcast stated that a bipartisan report gave the Obama administration a failing grade for its efforts to respond to a bioterrorist attack. The news broadcast invited the former New York City police commissioner, Howard Safir, to explain how the government would fare in combating such an attack. He said how "biological and chemical weapons are probable and relatively easy to disperse." Furthermore, Safir thought that efficiency in bioterrorism preparedness is not necessarily a question of money, but is instead dependent on putting resources in the right places. The broadcast suggested that the nation was not ready for something more serious.[66]

In a September 2016 interview conducted by Homeland Preparedness News, Daniel Gerstein, a senior policy researcher for the RAND Corporation, stresses the importance in preparing for potential bioterrorist attacks on the nation. He implored the U.S. government to take the proper and necessary actions to implement a strategic plan of action to save as many lives as possible and to safeguard against potential chaos and confusion. He believes that because there have been no significant instances of bioterrorism since the anthrax attacks in 2001, the government has allowed itself to become complacent making the country that much more vulnerable to unsuspecting attacks, thereby further endangering the lives of U.S. citizens.[67]

Gerstein formerly served in the Science and Technology Directorate of the Department of Homeland Security from 2011 to 2014. He claims there has not been a serious plan of action since 2004 during George W. Bush's presidency, in which he issued a Homeland Security directive delegating responsibilities among various federal agencies. He also stated that the blatant mishandling of the Ebola virus outbreak in 2014 attested to the government's lack of preparation. This past May, legislation that would create a national defense strategy was introduced in the Senate, coinciding with the timing of ISIS-affiliated terrorist groups get closer to weaponizing biological agents. In May 2016, Kenyan officials apprehended two members of an Islamic extremist group in motion to set off a biological bomb containing anthrax. Mohammed Abdi Ali, the believed leader of the group, who was a medical intern, was arrested along with his wife, a medical student. The two were caught just before carrying out their plan.[68] The Blue Ribbon Study Panel on Biodefense, which comprises a group of experts on national security and government officials, in which Gerstein had previously testified to, submitted its National Blueprint for Biodefense to Congress in October 2015 listing their recommendations for devising an effective plan.[67]

Bill Gates said in a February 18, 2017 Business Insider op-ed (published near the time of his Munich Security Conference speech) that it is possible for an airborne pathogen to kill at least 30 million people over the course of a year.[69] In a New York Times report, the Gates Foundation predicted that a modern outbreak similar to the Spanish Influenza pandemic (which killed between 50 million and 100 million people) could end up killing more than 360 million people worldwide, even considering widespread availability of vaccines and other healthcare tools. The report cited increased globalization, rapid international air travel, and urbanization as increased reasons for concern.[70] In a March 9, 2017, interview with CNBC, former U.S. Senator Joe Lieberman, who was co-chair of the bipartisan Blue Ribbon Study Panel on Biodefense, said a worldwide pandemic could end the lives of more people than a nuclear war. Lieberman also expressed worry that a terrorist group like ISIS could develop a synthetic influenza strain and introduce it to the world to kill civilians.[70] In July 2017, Robert C. Hutchinson, former agent at the Department of Homeland Security, called for a "whole-of-government" response to the next global health threat, which he described as including strict security procedures at our borders and proper execution of government preparedness plans.[70]

Also, novel approaches in biotechnology, such as synthetic biology, could be used in the future to design new types of biological warfare agents.[71][72][73] Special attention has to be laid on future experiments (of concern) that:[74]

  1. Would demonstrate how to render a vaccine ineffective;
  2. Would confer resistance to therapeutically useful antibiotics or antiviral agents;
  3. Would enhance the virulence of a pathogen or render a nonpathogen virulent;
  4. Would increase transmissibility of a pathogen;
  5. Would alter the host range of a pathogen;
  6. Would enable the evasion of diagnostic/detection tools;
  7. Would enable the weaponization of a biological agent or toxin

Most of the biosecurity concerns in synthetic biology, however, are focused on the role of DNA synthesis and the risk of producing genetic material of lethal viruses (e.g. 1918 Spanish flu, polio) in the lab.[75][76][77] The CRISPR/Cas system has emerged as a promising technique for gene editing. It was hailed by The Washington Post as "the most important innovation in the synthetic biology space in nearly 30 years."[78] While other methods take months or years to edit gene sequences, CRISPR speeds that time up to weeks.[78] However, due to its ease of use and accessibility, it has raised a number of ethical concerns, especially surrounding its use in the biohacking space.[79][80][81]

In 1999, the University of Pittsburgh's Center for Biomedical Informatics deployed the first automated bioterrorism detection system, called RODS (Real-Time Outbreak Disease Surveillance). RODS is designed to collect data from many data sources and use them to perform signal detection, that is, to detect a possible bioterrorism event at the earliest possible moment. RODS, and other systems like it, collect data from sources including clinic data, laboratory data, and data from over-the-counter drug sales.[78][82] In 2000, Michael Wagner, the codirector of the RODS laboratory, and Ron Aryel, a subcontractor, conceived the idea of obtaining live data feeds from "non-traditional" (non-health-care) data sources. The RODS laboratory's first efforts eventually led to the establishment of the National Retail Data Monitor, a system which collects data from 20,000 retail locations nationwide.[78]

On February 5, 2002, George W. Bush visited the RODS laboratory and used it as a model for a $300 million spending proposal to equip all 50 states with biosurveillance systems. In a speech delivered at the nearby Masonic temple, Bush compared the RODS system to a modern "DEW" line (referring to the Cold War ballistic missile early warning system).[83]

The principles and practices of biosurveillance, a new interdisciplinary science, were defined and described in the Handbook of Biosurveillance, edited by Michael Wagner, Andrew Moore and Ron Aryel, and published in 2006. Biosurveillance is the science of real-time disease outbreak detection. Its principles apply to both natural and man-made epidemics (bioterrorism).

Data which potentially could assist in early detection of a bioterrorism event include many categories of information. Health-related data such as that from hospital computer systems, clinical laboratories, electronic health record systems, medical examiner record-keeping systems, 911 call center computers, and veterinary medical record systems could be of help; researchers are also considering the utility of data generated by ranching and feedlot operations, food processors, drinking water systems, school attendance recording, and physiologic monitors, among others.[82]

In Europe, disease surveillance is beginning to be organized on the continent-wide scale needed to track a biological emergency. The system not only monitors infected persons, but attempts to discern the origin of the outbreak.

Researchers have experimented with devices to detect the existence of a threat:

Some research shows that ultraviolet avalanche photodiodes offer the high gain, reliability and robustness needed to detect anthrax and other bioterrorism agents in the air. The fabrication methods and device characteristics were described at the 50th Electronic Materials Conference in Santa Barbara on June 25, 2008. Details of the photodiodes were also published in the February 14, 2008, issue of the journal Electronics Letters and the November 2007 issue of the journal IEEE Photonics Technology Letters.[84]

The United States Department of Defense conducts global biosurveillance through several programs, including the Global Emerging Infections Surveillance and Response System.[85]

Another powerful tool developed within New York City for use in countering bioterrorism is the development of the New York City Syndromic Surveillance System. This system is essentially a way of tracking disease progression throughout New York City, and was developed by the New York City Department of Health and Mental Hygiene (NYC DOHMH) in the wake of the 9/11 attacks. The system works by tracking the symptoms of those taken into the emergency department—based on the location of the hospital to which they are taken and their home address—and assessing any patterns in symptoms. These established trends can then be observed by medical epidemiologists to determine if there are any disease outbreaks in any particular locales; maps of disease prevalence can then be created rather easily.[86] This is an obviously beneficial tool in fighting bioterrorism as it provides a means through which such attacks could be discovered in their nascence; assuming bioterrorist attacks result in similar symptoms across the board, this strategy allows New York City to respond immediately to any bioterrorist threats that they may face with some level of alacrity.

Response to bioterrorism incident or threat

[edit]

Government agencies which would be called on to respond to a bioterrorism incident would include law enforcement, hazardous materials and decontamination units, and emergency medical units, if available.

The US military has specialized units, which can respond to a bioterrorism event; among them are the United States Marine Corps' Chemical Biological Incident Response Force and the U.S. Army's 20th Support Command (CBRNE), which can detect, identify, and neutralize threats, and decontaminate victims exposed to bioterror agents. US response would include the Centers for Disease Control.

Historically, governments and authorities have relied on quarantines to protect their populations. International bodies such as the World Health Organization already devote some of their resources to monitoring epidemics and have served clearing-house roles in historical epidemics.

Media attention toward the seriousness of biological attacks increased in 2013 to 2014. In July 2013, Forbes published an article with the title "Bioterrorism: A Dirty Little Threat With Huge Potential Consequences."[87] In November 2013, Fox News reported on a new strain of botulism, saying that the Centers for Disease and Control lists botulism as one of two agents that have "the highest risks of mortality and morbidity", noting that there is no antidote for botulism.[88] USA Today reported that the U.S. military in November was trying to develop a vaccine for troops from the bacteria that cause the disease Q fever, an agent the military once used as a biological weapon.[89] In February 2014, the former special assistant and senior director for biodefense policy to President George W. Bush called the bioterrorism risk imminent and uncertain[90] and Congressman Bill Pascrell called for increasing federal measures against bioterrorism as a "matter of life or death."[91] The New York Times wrote a story saying the United States would spend $40 million to help certain low and middle-income countries deal with the threats of bioterrorism and infectious diseases.[92]

Bioterrorism can additionally harm the psychological aspect of victims and the general public. Victims exposed to biological weapons have shown an increased presence of clinical anxiety compared to the normal population. [93]

Bill Gates has warned that bioterrorism could kill more people than nuclear war.[94]

In February 2018, a CNN employee discovered on an airplane a "sensitive, top-secret document in the seatback pouch explaining how the Department of Homeland Security would respond to a bioterrorism attack at the Super Bowl."[95]

2017 U.S. budget proposal affecting bioterrorism programs

[edit]

President Donald Trump promoted his first budget around keeping America safe. However, one aspect of defense would receive less money: "protecting the nation from deadly pathogens, man-made or natural," according to The New York Times. Agencies tasked with biosecurity get a decrease in funding under the Administration's budget proposal.[96]

For example:[96]

"The next weapon of mass destruction may not be a bomb," Lawrence O. Gostin, the director of the World Health Organization's Collaborating Center on Public Health Law and Human Rights, told The New York Times. "It may be a tiny pathogen that you can't see, smell or taste, and by the time we discover it, it'll be too late."[96]

Lack of international standards on public health experiments

[edit]

Tom Inglesy, the CEO and director of the Center for Health Security at the Johns Hopkins Bloomberg School of Public Health[97] and an internationally recognized expert on public health preparedness, pandemic and emerging infectious disease said in 2017 that the lack of an internationally standardized approval process that could be used to guide countries in conducting public health experiments for resurrecting a disease that has already been eradicated increases the risk that the disease could be used in bioterrorism. This was in reference to the lab synthesis of horsepox in 2017 by researchers at the University of Alberta. The researchers recreated horsepox, an extinct cousin of the smallpox virus,[98] in order to research new ways to treat cancer.[99]

  1. ^ a b Hummel, Stephen; Burpo, F. John; Hershfield, Jeremy; Kick, Andrew; O'Donovan, Kevin J.; Barnhill, Jason (April 27, 2022). Cruickshank, Paul; Hummel, Kristina (eds.). "A New Age of Bioterror: Anticipating Exploitation of Tunable Viral Agents" (PDF). CTC Sentinel. 15 (4, Special Issue: The Biological Threat – Part One). West Point, New York: Combating Terrorism Center: 1–6. Archived (PDF) from the original on May 12, 2022. Retrieved May 12, 2022.
  2. ^ a b "Bioterrorism". www.interpol.int. Retrieved March 12, 2024.
  3. ^ a b c d e Croddy, Eric; Perez-Armendariz, Clarissa; Hart, John (2002). Chemical and Biological Warfare: A Comprehensive Survey for the Concerned Citizen. Copernicus Books. pp. 78-84. ISBN 0387950761.
  4. ^ Roberge, Lawrence F. (2019). "Agrobioterrorism". Defense Against Biological Attacks. pp. 359–383. doi:10.1007/978-3-030-03071-1_16. ISBN 978-3-030-03070-4. S2CID 239249186.
  5. ^ "Bioterrorism | Anthrax | CDC". www.cdc.gov. Retrieved October 25, 2017.
  6. ^ "Bioterrorism". Cambridge dictionary. Retrieved March 12, 2024.
  7. ^ "Bioterrorism Overview". Centers for Disease Control and Prevention. February 12, 2008. Archived from the original on March 3, 2016. Retrieved May 22, 2009.
  8. ^ Preston, Richard (2002). The Demon in the Freezer, Ballantine Books, New York. ISBN 9780345466631.
  9. ^ Advantages of Biologics as Weapons Bioterrorism: A Threat to National Security or Public Health Defining Issue? MM&I 554 University of Wisconsin–Madison and Wisconsin State Laboratory of Hygiene, September 30, 2008.
  10. ^ Joy, Bill (March 31, 2007), Why the Future Doesn't Need Us: How 21st Century Technologies Threaten to Make Humans an Endangered Species, Random House, ISBN 978-0-553-52835-0
  11. ^ "Bioterrorism - the high economic costs of an attack" (PDF). October 2002. Archived (PDF) from the original on October 9, 2022.
  12. ^ a b Gregory, B; Waag, D. (1997), Military Medicine: Medical aspects of biological warfare (PDF), Office of the Surgeon General, Department of the Army, Library of Congress 97-22242, archived from the original (PDF) on June 12, 2009, retrieved May 22, 2009
  13. ^ Experts Q & A, Public Broadcasting Service, December 15, 2006, archived from the original on May 20, 2009, retrieved May 22, 2009
  14. ^ W. Seth Carus, "R.I.S.E.", in Toxic Terror: Assessing Terrorist Use of Chemical and Biological Weapons (MIT Press, 2000), p.55, p.69
  15. ^ M Meselson, J Guillemin, M Hugh-Jones, A Langmuir, I Popova, A Shelokov, et al. The Sverdlovsk anthrax outbreak of 1979, PMID 7973702, doi:10.1126/science.7973702
  16. ^ "Smallpox". www.who.int. Retrieved June 18, 2022.
  17. ^ Past U.S. Incidents of Food Bioterrorism. In Bioterrorism: A Threat to National Security or Public Health Defining Issue, University of Wisconsin–Madison and the Wisconsin State Laboratory of Hygiene, MM&I 554, September 30, 2008[_permanent dead link_‍]
  18. ^ Novak, Matt (November 3, 2016). "The Largest Bioterrorism Attack In US History Was An Attempt To Swing An Election". Gizmodo. Retrieved December 2, 2016.
  19. ^ a b "CDC-Bacillus anthracis Incident, Kameido, Tokyo, 1993". Archived from the original on February 2, 2020. Retrieved October 6, 2016.
  20. ^ "U.S. officials declare researcher is anthrax killer - CNN.com". www.cnn.com.
  21. ^ Petersen, Carolyn (May 1995). "Cryptosporidium and the food supply". The Lancet. 345 (8958): 1128–1129. doi:10.1016/s0140-6736(95)90972-9. PMID 7723540. S2CID 26919903.
  22. ^ Lathrop, Peggy; Mann, Linda M. (2001). "Preparing for bioterrorism". Proceedings (Baylor University. Medical Center). 14 (3): 219–223. doi:10.1080/08998280.2001.11927766. PMC 1305820. PMID 16369620.
  23. ^ a b Wheelis, Mark; Casagrande, Rocco; Madden, Laurence V. (July 1, 2002). "Biological Attack on Agriculture: Low-Tech, High-Impact BioterrorismBecause bioterrorist attack requires relatively little specialized expertise and technology, it is a serious threat to US agriculture and can have very large economic repercussions". BioScience. 52 (7): 569–576. doi:10.1641/0006-3568(2002)052[0569:BAOALT]2.0.CO;2.
  24. ^ Weber, Stephen G; Bottei, Ed; Cook, Richard; O'Connor, Michael (August 2004). "SARS, emerging infections, and bioterrorism preparedness". The Lancet. Infectious Diseases. 4 (8): 483–484. doi:10.1016/S1473-3099(04)01098-9. PMC 7128359. PMID 15288816.
  25. ^ Cook, Alethia H.; Cohen, David B. (September 2008). "Pandemic Disease: A Past and Future Challenge to Governance in the United States". Review of Policy Research. 25 (5): 449–471. doi:10.1111/j.1541-1338.2008.00346.x. PMC 7169208. PMID 32327945.
  26. ^ Cook, Alethia H.; Cohen, David B. (September 2008). "Pandemic Disease: A Past and Future Challenge to Governance in the United States". The Review of Policy Research. 25 (5): 449–471. doi:10.1111/j.1541-1338.2008.00346.x. PMC 7169208. PMID 32327945.
  27. ^ Office of the President. White House. (November 1, 2005). "Press release: President outlines pandemic influenza preparations and response."
  28. ^ "CDC Tularemia - Emergency Preparedness & Response". February 21, 2019.
  29. ^ "CDC Tularemia - Key Facts About Tularemia". Archived from the original on June 19, 2010.
  30. ^ Adalja, Amesh A.; Toner, Eric; Inglesby, Thomas V. (March 5, 2015). "Clinical Management of Potential Bioterrorism-Related Conditions". New England Journal of Medicine. 372 (10): 954–962. doi:10.1056/NEJMra1409755. PMID 25738671.
  31. ^ Vietri, Nicholas J.; Purcell, Bret K.; Tobery, Steven A.; Rasmussen, Suzanne L.; Leffel, Elizabeth K.; Twenhafel, Nancy A.; Ivins, Bruce E.; Kellogg, Mark D.; Webster, Wendy M.; Wright, Mary E.; Friedlander, Arthur M. (2009). "A Short Course of Antibiotic Treatment Is Effective in Preventing Death from Experimental Inhalational Anthrax after Discontinuing Antibiotics". The Journal of Infectious Diseases. 199 (3): 336–41. doi:10.1086/596063. JSTOR 40254424. PMID 19099484.
  32. ^ Bisher, Jamie, "During World War I, Terrorists Schemed to Use Anthrax in the Cause of Finnish Independence," Military History, August 2003, pp. 17–22.Anthrax Sabotage in Finland
  33. ^ "Emerging Infectious Diseases journal". Archived from the original on October 15, 2010. Retrieved September 8, 2017.
  34. ^ Clarke, S. C. (2005). "Bacteria as potential tools in bioterrorism, with an emphasis on bacterial toxins". British Journal of Biomedical Science. 62 (1): 40–46. doi:10.1080/09674845.2005.11732685. PMID 15816214. S2CID 19601885.
  35. ^ Debora MacKenzie. "Anthrax attack bug 'identical' to army strain". New Scientist. Retrieved February 16, 2013.
  36. ^ "CDC Smallpox Home". February 19, 2019.
  37. ^ "CDC Smallpox - What CDC Is Doing to Protect the Public From Smallpox". Archived from the original on May 4, 2018. Retrieved December 18, 2018.
  38. ^ "IHB - The DoD Immunization Information and Training Portal". Archived from the original on August 14, 2009. Retrieved May 26, 2009.
  39. ^ "CDC Botulism - Emergency Preparedness & Response". August 19, 2019.
  40. ^ Nigam, PK; Nigam, A (2010). "BOTULINUM TOXIN". Indian Journal of Dermatology. 55 (1): 8–14. doi:10.4103/0019-5154.60343. PMC 2856357. PMID 20418969.
  41. ^ "CDC - Facts About Botulism". Archived from the original on July 3, 2017. Retrieved December 18, 2018.
  42. ^ "CDC Plague Information - Emergency Preparedness & Response". February 21, 2019.
  43. ^ "CDC - 01 This Page Has Moved - CDC Plague Home Page - CDC Division of Vector-Borne Infectious Diseases (DVBID)". Archived from the original on May 19, 2009.
  44. ^ "CDC Plague - Frequently Asked Questions (FAQ) About Plague". Archived from the original on May 28, 2009.
  45. ^ "CDC Viral Hemorrhagic Fevers - Emergency Preparedness & Response". May 16, 2019.
  46. ^ Olson, Kyle B. (August 4, 1999). "Aum Shinrikyo: Once and Future Threat?". Emerging Infectious Diseases. 5 (4): 413–416. doi:10.3201/eid0504.990409. PMC 2627754. PMID 10458955. Archived from the original on March 20, 2020. Retrieved February 8, 2020.
  47. ^ "CDC Brucellosis - Emergency Preparedness & Response". May 16, 2019.
  48. ^ "CDC Glanders". Archived from the original on February 9, 2010. Retrieved September 8, 2017.
  49. ^ "CDC Melioidosis". Archived from the original on February 11, 2010. Retrieved September 8, 2017.
  50. ^ "CDC Why has melioidosis become a current issue?". Archived from the original on February 11, 2010. Retrieved September 8, 2017.
  51. ^ "CDC Q Fever - Emergency Preparedness and Response". January 15, 2019.
  52. ^ "CDC Ricin - Emergency Preparedness & Response". May 16, 2019.
  53. ^ "Cholera". WebMD.
  54. ^ Roffey, R et al. “Biological Weapons and Bioterrorism Preparedness: Importance of Public-Health Awareness and International Cooperation.” Clinical microbiology and infection 8.8 (2002): 522–528. Web.
  55. ^ Kuntz, Carol; Salerno, Reynolds; Jacobs, Eli (May 15, 2013). A Biological Threat Prevention Strategy: Complicating Adversary Acquisition and Misuse of Biological Agents. Center for Strategic & International Studies. ISBN 978-1-4422-2474-2.
  56. ^ Nikolelis, Dimitrios P.; Nikoleli, Georgia-Paraskevi (March 12, 2016). Biosensors for Security and Bioterrorism Applications. Springer. ISBN 978-3-319-28926-7.
  57. ^ Bernett, Brian C. (December 2006), US Biodefense and Homeland Security: Toward Detection and Attribution (PDF), Monterey, California, United States: Naval Postgraduate School, p. 21, archived from the original (PDF) on February 29, 2008, retrieved May 24, 2009
  58. ^ a b c d United States. Cong. House. Committee on Homeland Security. Ensuring Effective Preparedness Responses and Recovery for Events Impacting Health Security Hearing before the Subcommittee on Emergency Preparedness, Response and Communications of the Committee on Homeland Security, House of Representatives, One Hundred Twelfth Congress, First Session, March 17, 2011. 112th Cong., 1st sess. HR 397. Washington: U.S. G.P.O., 2012. Print.
  59. ^ a b United States. Cong. House. Committee on Homeland Security. First Responder Technologies: Ensuring a Prioritized Approach for Homeland Security Research and Development: Joint Hearing before the Subcommittee on Emergency Preparedness, Response and Communications and the Subcommittee on Cybersecurity, Infrastructure Protection, and Security Technologies of the Committee on Homeland Security, House of Representatives, One Hundred Twelfth Congress, Second Session, May 9, 2012. 112th Cong., 2nd sess. HR 397. N.p.: n.p., n.d. Print.
  60. ^ "WKTV.com | A new Challenge for police and EMS personnel". September 15, 2016. Archived from the original on October 5, 2016. Retrieved October 3, 2016.
  61. ^ a b c "First responders train with new technology at N.Y.'s largest emergency response exercise - Homeland Preparedness News". September 19, 2016. Retrieved October 3, 2016.
  62. ^ "Watch NY police train for terrorist attacks, bombs, active shooters (videos)". September 15, 2016. Retrieved October 3, 2016.
  63. ^ a b Hylton, Wil S. "How Ready Are We for Bioterrorism?" The New York Times. The New York Times Company, October 26, 2011. Web.
  64. ^ a b United States. Cong. House. Committee on Homeland Security. Taking Measure of Countermeasures. Hearing before the Subcommittee on Emergency Preparedness, Response and Communications of the Committee on Homeland Security, House of Representatives, One Hundred Twelfth Congress, First Session, April 13, 2011, and May 12, 2011. 112 Cong., 1st sess. HR 397. Washington: U.S. G.P.O., 2012. Print.
  65. ^ John King, USA. CNNW. San Francisco. December 20, 2011. Television.
  66. ^ MSNBC News Live. MSNBC. New York City. January 26, 2010. Television
  67. ^ a b Rozens, Tracy (September 2, 2016). "RAND's Gerstein: U.S. needs biodefense strategy to protect against terror threats". Homeland Preparedness News. Retrieved September 19, 2016.
  68. ^ McCormick, Ty (May 4, 2016). "Foiled Kenya Anthrax Plot Hints At Islamic State's Scramble For Africa". Foreign Policy. Retrieved October 19, 2020.
  69. ^ Foundation, Bill Gates, Bill & Melinda Gates. "BILL GATES: A new kind of terrorism could wipe out 30 million people in less than a year — and we are not prepared". Business Insider. Retrieved October 19, 2020.{{[cite web](/wiki/Template:Cite%5Fweb "Template:Cite web")}}: CS1 maint: multiple names: authors list (link)
  70. ^ a b c Hutchinson, Robert C. (July 9, 2017). "Homeland Security Today: EXCLUSIVE: Pandemic Crossroads". www.hstoday.us. Retrieved September 12, 2017.[_dead link_‍]
  71. ^ Kelle, Alexander (2009). "Security Issues Related to Synthetic Biology: Between Threat Perceptions and Governance Options". Synthetic Biology. pp. 101–119. doi:10.1007/978-90-481-2678-1_7. ISBN 978-90-481-2677-4.
  72. ^ "JCVI: Research / Projects / Synthetic Genomics | Options for Governance / Overview". www.jcvi.org. Archived from the original on January 30, 2016. Retrieved January 24, 2016.
  73. ^ M.Buller, The potential use of genetic engineering to enhance orthopox viruses as bioweapons. Presentation at the International Conference ‘Smallpox Biosecurity. Preventing the Unthinkable’ (October 21–22, 2003) Geneva, Switzerland
  74. ^ Kelle A. 2007. Synthetic Biology & Biosecurity Awareness In Europe. Bradford Science and Technology Report No.9
  75. ^ Tumpey, T. M.; Basler, CF; Aguilar, PV; Zeng, H; Solórzano, A; Swayne, DE; Cox, NJ; Katz, JM; Taubenberger, JK; Palese, P; García-Sastre, A (October 7, 2005). "Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus". Science. 310 (5745): 77–80. Bibcode:2005Sci...310...77T. doi:10.1126/science.1119392. PMID 16210530. S2CID 14773861.
  76. ^ Cello, J.; Paul, A. V.; Wimmer, E. (2002). "Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template". Science. 297 (5583): 1016–1018. Bibcode:2002Sci...297.1016C. doi:10.1126/science.1072266. PMID 12114528. S2CID 5810309.
  77. ^ Wimmer, Eckard; Mueller, Steffen; Tumpey, Terrence M; Taubenberger, Jeffery K (December 1, 2009). "Synthetic viruses: a new opportunity to understand and prevent viral disease". Nature Biotechnology. 27 (12): 1163–72. doi:10.1038/nbt.1593. PMC 2819212. PMID 20010599.
  78. ^ a b c d Wagner, Michael M.; Espino, Jeremy; et al. (2004), "The role of clinical information systems in public health surveillance", Healthcare Information Management Systems (3 ed.), New York: Springer-Verlag, pp. 513–539
  79. ^ Kahn, Jennifer (November 9, 2015). "The Crispr Quandary". The New York Times. Retrieved January 24, 2016.
  80. ^ Ledford, Heidi (June 1, 2015). "CRISPR, the disruptor". Nature. 522 (7554): 20–24. Bibcode:2015Natur.522...20L. doi:10.1038/522020a. PMID 26040877. S2CID 4456595.
  81. ^ Basulto, Dominic (November 4, 2015). "Everything you need to know about why CRISPR is such a hot technology". The Washington Post. Retrieved January 24, 2016.
  82. ^ a b Wagner, Michael M.; Aryel, Ron; et al. (November 28, 2001), Availability and Comparative Value of Data Elements Required for an Effective Bioterrorism Detection System (PDF), Real-time Outbreak and Disease Surveillance Laboratory, archived from the original (PDF) on March 3, 2011, retrieved May 22, 2009
  83. ^ Togyer, Jason (June 2002), Pitt Magazine: Airborne Defense, University of Pittsburgh, archived from the original on June 16, 2010, retrieved May 22, 2009
  84. ^ Avalanche Photodiodes Target Bioterrorism Agents Newswise, Retrieved on June 25, 2008.
  85. ^ Pellerin, Cheryl. "Global Nature of Terrorism Drives Biosurveillance." Archived January 12, 2013, at the Wayback Machine American Forces Press Service, October 27, 2011.
  86. ^ Chen, H, D Zeng, and Y Pan. "Infectious Disease Informatics: Syndromic Surveillance for Public Health and Bio-Defense." 20120, XXII, 209p. 68 illus.., Hardcover.
  87. ^ Bell, Larry. "Bioterrorism: A Dirty Little Threat With Huge Potential Consequences". Forbes. July 21, 2013 (Retrieved February 17, 2014)
  88. ^ Heitz, David. "Deadly bioterror threats: 6 real risks". Fox News. November 2, 2013 (Retrieved February 17, 2014)
  89. ^ Locker, Ray. "Pentagon seeking vaccine for bioterror disease threat". USA Today. November 18, 2013 (Retrieved February 17, 2014)
  90. ^ Cohen, Bryan. "Kadlec says biological attack is uncertain, imminent reality" Archived February 9, 2015, at the Wayback Machine. Bio Prep Watch. February 17, 2014 (Retrieved February 17, 2014)
  91. ^ Cohen, Bryan. "Pascrell: Bioterror threat a life or death matter". Bio Prep Watch. February 12, 2014 (Retrieved February 17, 2014)
  92. ^ Tavernise, Sabrina. "U.S. Backs New Global Initiative Against Infectious Diseases". New York Times. February 13, 2014 (Retrieved February 17, 2014)
  93. ^ Mason, B. W., and R. A. Lyons. "Acute Psychological Effects of Suspected Bioterrorism." Journal of Epidemiology and Community Health (1979-), vol. 57, no. 5, 2003, pp. 353–54. JSTOR, Accessed 27 Oct. 2024.
  94. ^ "Bioterrorism could kill more people than nuclear war, Bill Gates to warn world leaders". The Telegraph. February 18, 2017. Archived from the original on January 12, 2022. Retrieved February 19, 2017.
  95. ^ Evensen, Jay (February 12, 2018). "Jay's Jokes: Did you forget your bioterrorism report on the plane?". DeseretNews.com. Archived from the original on February 17, 2018. Retrieved February 16, 2018.
  96. ^ a b c Baumgaertner, Emily (May 28, 2017). "Trump's Proposed Budget Cuts Trouble Bioterrorism Experts". The New York Times. Archived from the original on January 1, 2022. Retrieved May 30, 2017.
  97. ^ "Tom Inglesby, MD". Johns Hopkins Bloomberg School of Public Health.
  98. ^ "science".
  99. ^ Riley, Kim (August 10, 2017). "Bioterrorism threats require common global experimentation oversight, expert says". Homeland Preparedness News. Retrieved January 15, 2018.

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