CAPRIN2 (original) (raw)

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Protein-coding gene in humans

CAPRIN2
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4OUL, 4OUM
Identifiers
Aliases	CAPRIN2, C1QDC1, EEG-1, EEG1, RNG140, caprin family member 2
External IDs	OMIM: 610375; MGI: 2448541; HomoloGene: 11393; GeneCards: CAPRIN2; OMA:CAPRIN2 - orthologs
Gene location (Human)Chr.Chromosome 12 (human)[1]Band12p11.21Start30,709,552 bp[1]End30,754,951 bp[1]
Gene location (Mouse)Chr.Chromosome 6 (mouse)[2]Band6|6 G3Start148,743,990 bp[2]End148,797,735 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inspinal gangliacerebellar vermisright hemisphere of cerebellumtrigeminal gangliontesticlesural nervelateral nuclear group of thalamuspars compactapars reticulataexternal globus pallidusTop expressed inlensepithelium of lenszygoteprimary oocytesecondary oocytetail of embryoneural layer of retinalumbar spinal ganglionsupraoptic nucleusparaventricular nucleus of hypothalamusMore reference expression dataBioGPSn/a
Gene ontologyMolecular function signaling receptor binding protein binding RNA binding metal ion binding Cellular component centrosome receptor complex nucleus mitochondrion cytoplasm cytosol plasma membrane membrane Biological process positive regulation of canonical Wnt signaling pathway regulation of growth cell differentiation negative regulation of translation positive regulation of protein binding negative regulation of cell growth positive regulation of peptidyl-serine phosphorylation positive regulation of transcription by RNA polymerase II positive regulation of dendrite morphogenesis positive regulation of dendritic spine morphogenesis Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez65981232560EnsemblENSG00000110888ENSMUSG00000030309UniProtQ6IMN6Q05A80RefSeq (mRNA)NM_001002259NM_001206856NM_023925NM_032156NM_001319842NM_001319843NM_001319844NM_001319845NM_001319846NM_001301351NM_181541RefSeq (protein)NP_001002259NP_001193785NP_001306771NP_001306772NP_001306773NP_001306774NP_001306775NP_076414NP_115532NP_001288280NP_853519Location (UCSC)Chr 12: 30.71 – 30.75 MbChr 6: 148.74 – 148.8 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

caprin family member 2, also known as CAPRIN2, is a human gene.[5]

The protein encoded by this gene may be involved in the transitioning of erythroblasts from a highly proliferative state to a terminal phase of differentiation. High level expression of the encoded protein can lead to apoptosis. Several transcript variants encoding different isoforms have been found for this gene.[5]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110888 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030309 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b "Entrez Gene: caprin family member 2". Retrieved 2011-08-30.

• Human CAPRIN2 genome location and CAPRIN2 gene details page in the UCSC Genome Browser.

• Aerbajinai W, Lee YT, Wojda U, et al. (2004). "Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth". J. Biol. Chem. 279 (3): 1916–21. doi:10.1074/jbc.M305634200. PMID 14593112.

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

• Shiina N, Tokunaga M (2010). "RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain". J. Biol. Chem. 285 (31): 24260–9. doi:10.1074/jbc.M110.108944. PMC 2911287. PMID 20516077.

• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.

• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

• Ding Y, Xi Y, Chen T, et al. (2008). "Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation". J. Cell Biol. 182 (5): 865–72. doi:10.1083/jcb.200803147. PMC 2528581. PMID 18762581.

• Grill B, Wilson GM, Zhang KX, et al. (2004). "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins". J. Immunol. 172 (4): 2389–400. doi:10.4049/jimmunol.172.4.2389. PMID 14764709.